Details of the Target

General Information of Target

Target ID LDTP15670
Target Name Putative Ras-related protein Rab-1C (RAB1C)
Gene Name RAB1C
Synonyms
Putative Ras-related protein Rab-1C; hRab1c; EC 3.6.5.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALASSLIRQKREVREPGGSRPVSAQRRVCPRGTKSLCQKQLLILLSKVRLCGGRPARP
DRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQSAK
LGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASALYRQRRSGRAWYLGLDKEGQ
VMKGNRVKKTKAAAHFLPKLLEVAMYQEPSLHSVPEASPSSPPAP
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Membrane
Function Protein transport. Probably involved in vesicular traffic.
Uniprot ID
Q92928
HGNC ID
HGNC:23683

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E51(1.09)  LDD2208  [1]
DBIA
 Probe Info  		C200(0.83)  LDD0532  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
ATP probe
 Probe Info  		N.A.  LDD0035  [4]
TER-AC
 Probe Info  		N.A.  LDD0426  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C200(0.83)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C200(0.90)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C200(1.15)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C200(1.12)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C200(1.08)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C200(1.28)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C200(1.29)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C200(1.25)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C200(1.28)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C200(0.84)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C200(1.23)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C200(1.03)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C200(1.28)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C200(1.02)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C200(1.06)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C200(1.09)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C200(1.13)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C200(1.12)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C200(0.85)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C200(1.07)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C200(0.90)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C200(0.95)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C200(1.09)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C200(1.05)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C200(1.12)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C200(1.22)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C200(1.00)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C200(1.06)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C200(1.18)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C200(1.22)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C200(1.40)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C200(1.33)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C200(1.22)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C200(1.05)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C200(1.22)  LDD2161  [2]
 LDCM0323  AC6 HCT 116 C200(0.98)  LDD0640  [2]
 LDCM0334  AC7 HCT 116 C200(0.95)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C200(0.96)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C200(1.03)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C200(0.83)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C200(1.11)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C200(1.22)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C200(1.14)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C200(0.69)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C200(0.75)  LDD0690  [2]
 LDCM0404  CL17 HCT 116 C200(0.28)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C200(1.02)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C200(1.13)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C200(1.09)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C200(1.27)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C200(0.81)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C200(0.81)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C200(0.89)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C200(0.89)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C200(0.96)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C200(1.11)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C200(1.02)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C200(0.98)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C200(0.87)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C200(1.12)  LDD0737  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
5 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.