Details of the Target

General Information of Target

Target ID LDTP15651
Target Name Zinc finger CCHC domain-containing protein 14 (ZCCHC14)
Gene Name ZCCHC14
Gene ID 23174
Synonyms
KIAA0579; Zinc finger CCHC domain-containing protein 14; BDG-29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFIKVMFGAGCSVLVNTSCRLVNLTAHLRQKAGLPPDATIALLAEDGNLVSLEEDLKEGA
SRAQTMGNSLLKERAIYVLVRIIKGEDMASTRYESLLENLDDHYPELAEELRRLSGLSSV
GHNWRKRMGTRRGRHEQSPTSRPRKGPD
Target Bioclass
Other
Uniprot ID
Q8WYQ9
Ensemble ID
ENST00000268616.9
HGNC ID
HGNC:24134

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C362(2.12)  LDD3369  [1]
IPM
 Probe Info  		C362(0.00); C262(0.00); C159(0.00)  LDD2156  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C362(0.85)  LDD1507  [4]
 LDCM0259  AC14 HEK-293T C362(1.16)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C362(1.00)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C362(0.85)  LDD1515  [4]
 LDCM0281  AC21 HEK-293T C362(1.09)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C362(1.06)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C362(1.10)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C362(0.82)  LDD1524  [4]
 LDCM0289  AC29 HEK-293T C362(1.08)  LDD1528  [4]
 LDCM0291  AC30 HEK-293T C362(1.04)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C362(1.02)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C362(1.00)  LDD1533  [4]
 LDCM0298  AC37 HEK-293T C362(1.06)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C362(1.08)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C362(0.86)  LDD1539  [4]
 LDCM0303  AC41 HEK-293T C362(0.96)  LDD1542  [4]
 LDCM0307  AC45 HEK-293T C362(1.13)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C362(1.04)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C362(1.07)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C362(0.98)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C362(1.06)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C362(1.14)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C362(1.03)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C362(1.01)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C362(0.89)  LDD1559  [4]
 LDCM0323  AC6 HEK-293T C362(0.95)  LDD1562  [4]
 LDCM0325  AC61 HEK-293T C362(1.20)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C362(1.02)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C362(1.11)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C362(1.13)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C362(1.02)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C362(0.94)  LDD1570  [4]
 LDCM0368  CL10 HEK-293T C362(1.02)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C362(1.06)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C362(1.16)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C362(1.03)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C362(0.95)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C362(0.99)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C362(1.15)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C362(0.97)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C362(1.03)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C362(0.92)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C362(0.99)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C362(1.14)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C362(1.03)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C362(1.04)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C362(0.96)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C362(1.08)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C362(1.03)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C362(1.03)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C362(0.89)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C362(0.96)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C362(1.09)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C362(1.03)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C362(0.93)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C362(1.00)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C362(1.22)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C362(1.01)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C362(1.04)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C362(0.90)  LDD1608  [4]
 LDCM0407  CL2 HEK-293T C362(0.98)  LDD1611  [4]
 LDCM0409  CL21 HEK-293T C362(1.19)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C362(1.31)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C362(1.05)  LDD1615  [4]
 LDCM0414  CL26 HEK-293T C362(1.07)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C362(0.94)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C362(0.97)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C362(0.93)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C362(1.09)  LDD1622  [4]
 LDCM0422  CL33 HEK-293T C362(0.98)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C362(1.17)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C362(1.05)  LDD1628  [4]
 LDCM0428  CL39 HEK-293T C362(0.98)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C362(1.09)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C362(0.98)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C362(0.85)  LDD1635  [4]
 LDCM0435  CL45 HEK-293T C362(1.26)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C362(1.06)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C362(1.08)  LDD1641  [4]
 LDCM0440  CL5 HEK-293T C362(1.12)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C362(1.30)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C362(0.98)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C362(0.95)  LDD1647  [4]
 LDCM0448  CL57 HEK-293T C362(1.21)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C362(1.17)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C362(1.06)  LDD1653  [4]
 LDCM0454  CL62 HEK-293T C362(1.06)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C362(1.02)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C362(1.01)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C362(0.95)  LDD1660  [4]
 LDCM0461  CL69 HEK-293T C362(1.11)  LDD1664  [4]
 LDCM0463  CL70 HEK-293T C362(1.28)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C362(1.01)  LDD1667  [4]
 LDCM0467  CL74 HEK-293T C362(0.93)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C362(1.02)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C362(0.93)  LDD1673  [4]
 LDCM0475  CL81 HEK-293T C362(1.20)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C362(1.13)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C362(1.06)  LDD1680  [4]
 LDCM0480  CL86 HEK-293T C362(1.07)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C362(0.87)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C362(1.07)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C362(0.94)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C362(1.13)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C362(1.10)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C362(1.19)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C362(0.94)  LDD1693  [4]
 LDCM0493  CL98 HEK-293T C362(0.98)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C362(0.94)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C362(1.26)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C362(0.96)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C362(0.80)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C362(0.82)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C362(0.83)  LDD1497  [4]
 LDCM0024  KB05 OAW-42 C362(2.12)  LDD3369  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myogenin (MYOG) . P15173
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Four and a half LIM domains protein 3 (FHL3) . Q13643
Puratrophin-1 (PLEKHG4) . Q58EX7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402