Details of the Target

General Information of Target

Target ID LDTP15596
Target Name Protein FAM110B (FAM110B)
Gene Name FAM110B
Gene ID 90362
Synonyms
C8orf72; Protein FAM110B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSNESCLPYYTAHSYSSMSAFKTSMGDLQRQLYNRGEYNIFKYAPMFESNFIQINKKGEV
IDVHNRVRMVTVGIVCTSPILPLPDVMVLAQPTKICEQHVRWGRFAKGRGRRPVKTLELT
RLLPLKFVKISIHDHEKQQLRLKLATGRTFYLQLCPSSDTREDLFCYWEKLVYLLRPPVE
SYCSTPTLLSGDAPPEDNKSLVAAELHREGDQSETGLYKPCDVSAATSSAYAGGEGIQHA
SHGTASAASPSTSTPGAAEGGAARTAGGMAVAGTATGPRTDVAIAGAAMSPATGAMSIAT
TKSAGPGQVTTALAGAAIKNPGENESSKSMAGAANISSEGISLALVGAASTSLEGTSTSM
AGAASLSQDSSLSAAFAGSITTSKCAAERTEGPAVGPLISTLQSEGYMSERDGSQKVSQP
SAEVWNENKERREKKDRHPSRKSSHHRKAGESHRRRAGDKNQKASSHRSASGHKNTRDDK
KEKGYSNVRGKRHGSSRKSSTHSSTKKESRTTQELGKNQSASSTGALQKKASKISSFLRS
LRATPGSKTRVTSHDREVDIVAKMVEKQNIEAKVEKAQGGQELEMISGTMTSEKTEMIVF
ETKSI
Target Bioclass
Other
Family
FAM110 family
Subcellular location
Cytoplasm
Function May be involved in tumor progression.
Uniprot ID
Q8TC76
Ensemble ID
ENST00000361488.7
HGNC ID
HGNC:28587

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C248(2.14)  LDD3401  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C86(0.92)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C86(1.02)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C86(0.91)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C86(0.91)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C86(0.93)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C86(1.00)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C86(0.93)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C86(0.86)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C86(0.95)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C86(0.94)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C86(0.93)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C86(0.95)  LDD1527  [3]
 LDCM0292  AC31 HEK-293T C86(0.92)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C86(1.01)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C86(1.04)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C86(0.95)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C86(0.94)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C86(0.98)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C86(0.95)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C86(1.05)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C86(1.00)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C86(1.02)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C86(0.98)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C86(1.07)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C86(0.96)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C86(1.11)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C86(0.94)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C86(0.95)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C86(0.86)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C86(0.94)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C86(0.84)  LDD1568  [3]
 LDCM0356  AKOS034007680 HEK-293T C86(0.98)  LDD1570  [3]
 LDCM0367  CL1 HEK-293T C86(1.03)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C248(0.59)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C86(1.00)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C248(0.97); C86(1.00)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C248(0.97); C86(0.98)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C248(0.76)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C86(0.87)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C248(1.08); C86(0.93)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C248(1.05); C86(0.96)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C248(0.89)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C86(0.95)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C86(1.30)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C248(1.13); C86(0.92)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C248(0.97); C86(0.98)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C248(0.92)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C86(1.10)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C248(1.01); C86(1.00)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C248(0.92); C86(0.99)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C248(0.96)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C86(1.02)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C248(1.15); C86(0.90)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C248(0.82); C86(1.05)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C248(0.96)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C86(0.98)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C248(1.03); C86(1.07)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C248(0.92); C86(1.11)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C248(0.84)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C86(0.99)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C248(1.08); C86(0.98)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C248(0.92); C86(1.01)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C248(0.86)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C86(1.31)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C248(0.99); C86(1.11)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C248(1.62); C86(1.13)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C248(0.94)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C86(1.27)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C86(1.27)  LDD1609  [3]
 LDCM0407  CL2 HEK-293T C248(1.01); C86(1.03)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C86(1.40)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C86(1.55)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C86(0.91)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C248(1.05); C86(0.91)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C248(0.95); C86(0.94)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C248(1.05)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C86(1.00)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C248(0.89); C86(1.10)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C86(1.06)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C86(1.17)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C86(1.40)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C86(0.92)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C248(1.07); C86(1.24)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C248(0.85)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C248(1.21)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C86(1.03)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C86(1.28)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C86(1.11)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C86(1.39)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C86(0.92)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C86(1.04)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C248(1.09); C86(0.91)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C248(0.88)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C86(0.99)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C86(1.07)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C86(1.27)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C86(1.39)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C86(1.22)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C86(0.87)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C248(1.27); C86(0.85)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C248(1.32); C86(1.02)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C248(1.12)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C86(0.96)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C86(1.14)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C86(1.17)  LDD1663  [3]
 LDCM0464  CL71 HEK-293T C86(1.38)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C86(0.92)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C248(0.96); C86(0.97)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C248(1.00)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C86(1.15)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C86(1.08)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C86(1.62)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C86(1.19)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C86(1.37)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C86(0.95)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C248(0.86); C86(1.01)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C248(0.87); C86(1.10)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C248(0.72)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C86(1.05)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C86(1.44)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C86(1.12)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C86(1.52)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C86(0.94)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C248(0.94); C86(0.91)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C248(0.89); C86(1.32)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C248(1.01); C86(1.23)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C248(1.17); C86(1.00)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C248(1.35); C86(0.86)  LDD1631  [3]
 LDCM0022  KB02 RD C248(1.96)  LDD2567  [1]
 LDCM0023  KB03 RD C248(1.97)  LDD2984  [1]
 LDCM0024  KB05 RD C248(2.14)  LDD3401  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein PKNOX1 (PKNOX1) TALE/MEIS homeobox family P55347
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402