Details of the Target

General Information of Target

Target ID LDTP15509
Target Name Serum response factor-binding protein 1 (SRFBP1)
Gene Name SRFBP1
Gene ID 153443
Synonyms
Serum response factor-binding protein 1; SRF-dependent transcription regulation-associated protein; p49/STRAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLK
DVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWAL
GNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRN
KHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIF
KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK
EKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQE
RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG
PTGSGPLLHIPHRAIPTWRQGIQRRV
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
Uniprot ID
Q8NEF9
Ensemble ID
ENST00000339397.5
HGNC ID
HGNC:26333

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C300(2.52)  LDD3332  [2]
BTD
 Probe Info  		C300(0.64)  LDD2129  [3]
AHL-Pu-1
 Probe Info  		C300(2.67)  LDD0171  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C300(5.62)  LDD0371  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C300(2.67)  LDD0171  [4]
 LDCM0284  AC24 HEK-293T C300(0.97)  LDD1523  [11]
 LDCM0293  AC32 HEK-293T C300(1.13)  LDD1532  [11]
 LDCM0302  AC40 HEK-293T C300(1.11)  LDD1541  [11]
 LDCM0310  AC48 HEK-293T C300(0.92)  LDD1549  [11]
 LDCM0319  AC56 HEK-293T C300(0.93)  LDD1558  [11]
 LDCM0328  AC64 HEK-293T C300(0.90)  LDD1567  [11]
 LDCM0345  AC8 HEK-293T C300(0.88)  LDD1569  [11]
 LDCM0275  AKOS034007705 HEK-293T C300(0.92)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 13.50  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0371  CL102 HEK-293T C300(0.88)  LDD1575  [11]
 LDCM0375  CL106 HEK-293T C300(0.94)  LDD1579  [11]
 LDCM0380  CL110 HEK-293T C300(0.88)  LDD1584  [11]
 LDCM0384  CL114 HEK-293T C300(1.01)  LDD1588  [11]
 LDCM0388  CL118 HEK-293T C300(1.01)  LDD1592  [11]
 LDCM0390  CL12 HEK-293T C300(0.98)  LDD1594  [11]
 LDCM0393  CL122 HEK-293T C300(0.67)  LDD1597  [11]
 LDCM0397  CL126 HEK-293T C300(0.60)  LDD1601  [11]
 LDCM0401  CL14 HEK-293T C300(0.91)  LDD1605  [11]
 LDCM0407  CL2 HEK-293T C300(1.05)  LDD1611  [11]
 LDCM0412  CL24 HEK-293T C300(1.05)  LDD1616  [11]
 LDCM0414  CL26 HEK-293T C300(0.86)  LDD1618  [11]
 LDCM0425  CL36 HEK-293T C300(1.15)  LDD1629  [11]
 LDCM0438  CL48 HEK-293T C300(1.09)  LDD1642  [11]
 LDCM0441  CL50 HEK-293T C300(0.94)  LDD1645  [11]
 LDCM0452  CL60 HEK-293T C300(1.18)  LDD1655  [11]
 LDCM0454  CL62 HEK-293T C300(1.07)  LDD1657  [11]
 LDCM0465  CL72 HEK-293T C300(1.23)  LDD1668  [11]
 LDCM0467  CL74 HEK-293T C300(0.73)  LDD1670  [11]
 LDCM0478  CL84 HEK-293T C300(0.75)  LDD1681  [11]
 LDCM0480  CL86 HEK-293T C300(0.48)  LDD1683  [11]
 LDCM0491  CL96 HEK-293T C300(0.47)  LDD1694  [11]
 LDCM0493  CL98 HEK-293T C300(1.07)  LDD1696  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C300(2.01)  LDD1702  [3]
 LDCM0427  Fragment51 HEK-293T C300(1.01)  LDD1631  [11]
 LDCM0022  KB02 A2058 C300(1.36)  LDD2253  [2]
 LDCM0023  KB03 MDA-MB-231 C300(3.81)  LDD1701  [3]
 LDCM0024  KB05 MKN45 C300(2.52)  LDD3332  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C300(0.64)  LDD2129  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402