Details of the Target

General Information of Target

Target ID LDTP15182
Target Name Zinc finger protein 574 (ZNF574)
Gene Name ZNF574
Gene ID 64763
Synonyms
Zinc finger protein 574
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAILSLRAPGPWQAMQVWADRTLLTPHTGVTSQVLGVAAAVMTPLPGGHAAGRTREARWD
AMEYDEKLARFRQAHLNPFNKQSGPRQHEQGPGEEVPDVTPEEALPELPPGEPEFRCPER
VMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLK
LQELKDPNEDEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCYYRCHS
KCLNLISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYT
GQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFSY
VEELVEIRKLRQDILLMKPYFITCREAMEARLLLQLQDRQHFVENDEMYSVQDLLDVHAG
RLGCSLTEIHTLFAKHIKLDCERCQAKGFVCELCREGDVLFPFDSHTSVCADCSAVFHRD
CYYDNSTTCPKCARLSLRKQSLFQEPGPDVEA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q6ZN55
Ensemble ID
ENST00000359044.5
HGNC ID
HGNC:26166

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.S728P .
IM95 SNV: p.E819K DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.P714S DBIA    Probe Info 
JURKAT SNV: p.C612S .
KYSE150 SNV: p.P694L .
MFE296 SNV: p.Y16C .
NCIH2172 SNV: p.C771F DBIA    Probe Info 
NCIH716 SNV: p.E282Q .
RKO SNV: p.G285V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C745(1.25)  LDD3312  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C394(1.03)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C656(0.97)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C656(0.94)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C656(0.87)  LDD1513  [3]
 LDCM0278  AC19 HEK-293T C394(1.06)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C656(0.86)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C656(1.09)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C656(0.98)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C656(0.90)  LDD1522  [3]
 LDCM0287  AC27 HEK-293T C394(1.07)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C656(0.85)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C656(0.97)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C394(1.04)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C656(1.04)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C656(0.83)  LDD1531  [3]
 LDCM0296  AC35 HEK-293T C394(0.97)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C656(0.83)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C656(1.21)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C656(0.97)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C656(1.01)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C656(0.85)  LDD1540  [3]
 LDCM0305  AC43 HEK-293T C394(1.08)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C656(0.85)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C656(0.92)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C656(1.04)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C656(1.13)  LDD1548  [3]
 LDCM0312  AC5 HEK-293T C656(0.88)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C394(0.95)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C656(0.96)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C656(1.36)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C656(1.04)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C656(1.03)  LDD1557  [3]
 LDCM0322  AC59 HEK-293T C394(0.92)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C656(0.91)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C656(0.87)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C656(0.92)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C656(1.03)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C656(0.92)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C656(0.83)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C656(1.01)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C656(0.92)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C656(1.14)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C656(0.98)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C656(0.98)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C656(0.90)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C656(0.92)  LDD1583  [3]
 LDCM0383  CL113 HEK-293T C656(0.95)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C656(0.99)  LDD1591  [3]
 LDCM0392  CL121 HEK-293T C656(1.00)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C656(1.05)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C656(1.17)  LDD1604  [3]
 LDCM0406  CL19 HEK-293T C394(1.13)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C656(1.15)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C656(1.41)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C656(1.26)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C656(1.21)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C656(0.92)  LDD1617  [3]
 LDCM0420  CL31 HEK-293T C394(1.08)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C656(0.96)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C656(1.07)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C656(1.25)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C656(1.24)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C656(1.04)  LDD1630  [3]
 LDCM0433  CL43 HEK-293T C394(1.08)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C656(1.01)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C656(1.32)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C656(1.30)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C656(0.87)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C656(1.01)  LDD1643  [3]
 LDCM0446  CL55 HEK-293T C394(1.14)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C656(1.08)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C656(1.04)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C656(1.20)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C656(1.11)  LDD1653  [3]
 LDCM0453  CL61 HEK-293T C656(0.89)  LDD1656  [3]
 LDCM0459  CL67 HEK-293T C394(1.16)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C656(0.99)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C656(1.35)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C394(1.28)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C656(1.14)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C656(1.26)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C656(0.99)  LDD1669  [3]
 LDCM0472  CL79 HEK-293T C394(1.15)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C656(0.96)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C656(0.98)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C656(1.06)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C656(1.04)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C656(1.04)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C656(1.01)  LDD1682  [3]
 LDCM0484  CL9 HEK-293T C656(1.06)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C394(1.19)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C656(0.94)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C656(1.08)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C656(0.99)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C656(0.99)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C656(0.90)  LDD1695  [3]
 LDCM0022  KB02 42-MG-BA C745(1.75)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C745(1.52)  LDD2661  [1]
 LDCM0024  KB05 HMCB C745(1.25)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Doublecortin domain-containing protein 2B (DCDC2B) . A2VCK2
Leucine-rich repeat-containing protein 73 (LRRC73) . Q5JTD7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402