Details of the Target

General Information of Target

Target ID LDTP15167
Target Name Protein delta homolog 2 (DLK2)
Gene Name DLK2
Gene ID 65989
Synonyms
EGFL9; Protein delta homolog 2; DLK-2; Epidermal growth factor-like protein 9; EGF-like protein 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGWRYLICVSFLLTILLELTYQGPPVPASSSTKLLMTSYSMRSTVVSRYAHTLVTSVLF
NPHAEAHEAIFDLDLPHLAFISNFTMTINNKVYIAEVKEKHQAKKIYEEAHQQGKTAAHV
GIRDRESEKFRISTSLAAGTEVTFSLAYEELLQRHQGQYQLVVSLRPGQLVKRLSIEVTV
SERTGISYVHIPPLRTGRLRTNAHASEVDSPPSTRIERGETCVRITYCPTLQDQSSISGS
GIMADFLVQYDVVMEDIIGDVQIYDDYFIHYFAPRGLPPMEKNVVFVIDVSSSMFGTKME
QTKTAMNVILSDLQANDYFNIISFSDTVNVWKAGGSIQATIQNVHSAKDYLHCMEADGWT
DVNSALLAAASVLNHSNQEPGRGPSVGRIPLIIFLTDGEPTAGVTTPSVILSNVRQALGH
RVSLFSLAFGDDADFTLLRRLSLENRGIARRIYEDTDAALQLKGLYEEISMPLLADVRLN
YLGGLVGASPWAVFPNYFGGSELVVAGQVQPGKQELGIHLAARGPKDQLLVAHHSEGATN
NSQKAFGCPGEPAPNVAHFIRRLWAYVTIGELLDAHFQARDTTTRHLLAAKVLNLSLEYN
FVTPLTSLVMVQPKQASEETRRQTSTSAGPDTIMPSSSSRHGLGVSTAQPALVPKVISPK
SRPVKPKFYLSSTTTASTKKMLSSKELEPLGESPHTLSMPTYPKAKIPAQQDSGTLAQPT
LRTKPTILVPSNSGTLLPLKPGSLSHQNPDILPTNSRTQVPPVKPGIPASPKADTVKCVT
PLHSKPGAPSHPQLGALTSQAPKGLPQSRPGVSTLQVPKYPLHTRPRVPAPKTRNNMPHL
GPGILLSKTPKILLSLKPSAPPHQISTSISLSKPETPNPHMPQTPLPPRPDRPRPPLPES
LSTFPNTISSSTGPSSTTTTSVLGEPLPMPFTPTLPPGRFWHQYDLLPGPQRTRQVLGPS
RPGVPTMSLLNSSRPTPEGSPPNLPILLPSSILPEAISLLLLPEELELLSESMVESKFVE
SLNPPAFYTFLTPDEDGSPNWDGNSEEILGGAGGSMESQGSSVGLAKGTLPSIFTFSSSV
DGDPHFVIQIPHSEEKICFTLNGHPGDLLQLIEDPKAGLHVSGKLLGAPPRPGHKDQTRT
YFQIITVTTDKPRAYTITISRSSISLRGEGTLRLSWDQPALLKRPQLELYVAAAARLTLR
LGPYLEFLVLRHRYRHPSTLQLPHLGFYVANGSGLSPSARGLIGQFQHADIRLVTGPMGP
CLRRHHGPDVPVILGKRLLKDSPRLLPRWASCWLVKRSHVELLLGHPYLSYVL
Target Bioclass
Other
Subcellular location
Membrane
Function Regulates adipogenesis.
Uniprot ID
Q6UY11
Ensemble ID
ENST00000357338.3
HGNC ID
HGNC:21113

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C5(0.95)  LDD1702  [1]
DBIA
 Probe Info  		C171(0.49)  LDD1508  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C171(0.49)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C171(0.90)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C171(0.84)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C171(0.89)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C171(1.04)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C171(0.91)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C171(0.97)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C171(0.21)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C171(1.07)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C171(1.19)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C171(0.73)  LDD1527  [2]
 LDCM0291  AC30 HEK-293T C171(0.85)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C171(0.92)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C171(1.29)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C171(0.89)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C171(0.90)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C171(0.99)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C171(1.02)  LDD1540  [2]
 LDCM0304  AC42 HEK-293T C171(1.03)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C171(1.05)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C171(0.94)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C171(1.09)  LDD1548  [2]
 LDCM0313  AC50 HEK-293T C171(1.09)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C171(1.11)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C171(0.85)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C171(0.92)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C171(1.05)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C171(0.80)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C171(1.00)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C171(0.84)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C171(0.94)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C171(0.96)  LDD1568  [2]
 LDCM0368  CL10 HEK-293T C171(1.33)  LDD1572  [2]
 LDCM0371  CL102 HEK-293T C171(0.88)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C171(0.84)  LDD1579  [2]
 LDCM0379  CL11 HEK-293T C171(1.66)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C171(0.97)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C171(0.88)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C171(0.96)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C171(0.96)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C171(1.03)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C171(0.78)  LDD1605  [2]
 LDCM0405  CL18 HEK-293T C171(1.15)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C171(1.00)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C171(1.44)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C171(2.08)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C171(1.71)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C171(0.88)  LDD1618  [2]
 LDCM0419  CL30 HEK-293T C171(1.28)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C171(1.58)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C171(1.61)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C171(2.60)  LDD1628  [2]
 LDCM0432  CL42 HEK-293T C171(1.24)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C171(1.64)  LDD1638  [2]
 LDCM0436  CL46 HEK-293T C171(1.59)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C171(2.13)  LDD1641  [2]
 LDCM0441  CL50 HEK-293T C171(0.92)  LDD1645  [2]
 LDCM0445  CL54 HEK-293T C171(1.09)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C171(1.35)  LDD1650  [2]
 LDCM0449  CL58 HEK-293T C171(1.47)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C171(2.16)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C171(1.21)  LDD1654  [2]
 LDCM0454  CL62 HEK-293T C171(0.83)  LDD1657  [2]
 LDCM0458  CL66 HEK-293T C171(1.28)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C171(1.36)  LDD1663  [2]
 LDCM0463  CL70 HEK-293T C171(1.44)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C171(1.82)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C171(0.89)  LDD1670  [2]
 LDCM0471  CL78 HEK-293T C171(1.23)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C171(1.05)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C171(1.04)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C171(1.28)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C171(1.45)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C171(0.86)  LDD1683  [2]
 LDCM0485  CL90 HEK-293T C171(0.94)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C171(1.11)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C171(1.26)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C171(1.08)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C171(1.02)  LDD1696  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C5(0.95)  LDD1702  [1]
 LDCM0427  Fragment51 HEK-293T C171(1.03)  LDD1631  [2]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060