Details of the Target

General Information of Target

Target ID LDTP15123
Target Name Embigin (EMB)
Gene Name EMB
Gene ID 133418
Synonyms
Embigin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSATTACWPAFTVLGEARGDQVDWSRLYRDTGLVKMSRKPRASSPFSNNHPSTPKRFPRQ
PRREKGPVKEVPGTKGSP
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function
Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane.
Uniprot ID
Q6PCB8
Ensemble ID
ENST00000303221.10
HGNC ID
HGNC:30465

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II Deletion: p.S68_S69del .
HT115 SNV: p.V158A; p.E297Ter .
Ishikawa (Heraklio) 02 ER SNV: p.T102S .
JHH6 SNV: p.G214Ter .
KMS12BM SNV: p.Y140C .
KYSE30 SNV: p.K290R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C180(0.82)  LDD1492  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C180(1.26)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C180(1.16)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C180(1.21)  LDD1509  [1]
 LDCM0276  AC17 HEK-293T C180(1.11)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C180(1.08)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C180(1.71)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C180(0.99)  LDD1518  [1]
 LDCM0284  AC24 HEK-293T C180(0.98)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C180(1.11)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C180(1.16)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C180(1.06)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C180(1.04)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C180(0.96)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C180(1.33)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C180(1.16)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C180(1.24)  LDD1535  [1]
 LDCM0302  AC40 HEK-293T C180(1.12)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C180(1.13)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C180(1.19)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C180(1.28)  LDD1544  [1]
 LDCM0310  AC48 HEK-293T C180(1.15)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C180(1.15)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C180(1.07)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C180(1.09)  LDD1553  [1]
 LDCM0319  AC56 HEK-293T C180(1.08)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C180(1.21)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C180(1.04)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C180(1.10)  LDD1561  [1]
 LDCM0328  AC64 HEK-293T C180(1.05)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C180(0.95)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C180(1.13)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C180(1.14)  LDD1514  [1]
 LDCM0369  CL100 HEK-293T C180(1.14)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C180(1.17)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C180(1.24)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C180(1.14)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C180(1.05)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C180(1.12)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C180(1.13)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C180(1.15)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C180(1.24)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C180(1.10)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C180(1.41)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C180(1.29)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C180(1.20)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C180(1.16)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C180(1.12)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C180(1.30)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C180(1.21)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C180(1.18)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C180(1.23)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C180(1.26)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C180(1.10)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C180(1.17)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C180(1.11)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C180(1.17)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C180(1.33)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C180(1.28)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C180(1.22)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C180(1.23)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C180(1.09)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C180(0.99)  LDD1611  [1]
 LDCM0412  CL24 HEK-293T C180(1.14)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C180(1.04)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C180(1.16)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C180(1.07)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C180(1.23)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C180(1.12)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C180(1.18)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C180(1.12)  LDD1624  [1]
 LDCM0425  CL36 HEK-293T C180(1.22)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C180(1.13)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C180(1.21)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C180(1.11)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C180(1.12)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C180(1.25)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C180(1.01)  LDD1637  [1]
 LDCM0438  CL48 HEK-293T C180(1.08)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C180(1.01)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C180(1.30)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C180(1.16)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C180(1.08)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C180(1.16)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C180(1.12)  LDD1649  [1]
 LDCM0451  CL6 HEK-293T C180(1.16)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C180(1.15)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C180(1.18)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C180(1.17)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C180(1.26)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C180(1.15)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C180(1.18)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C180(1.20)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C180(1.10)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C180(1.12)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C180(1.12)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C180(1.07)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C180(1.21)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C180(1.10)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C180(1.13)  LDD1675  [1]
 LDCM0478  CL84 HEK-293T C180(1.30)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C180(1.09)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C180(1.09)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C180(1.10)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C180(1.11)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C180(1.11)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C180(0.94)  LDD1689  [1]
 LDCM0491  CL96 HEK-293T C180(1.27)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C180(1.08)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C180(1.12)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C180(1.19)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C180(1.19)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C180(1.10)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C180(0.82)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C180(1.03)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C180(0.85)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060