Details of the Target

General Information of Target

Target ID LDTP15092
Target Name Zinc finger and SCAN domain-containing protein 25 (ZSCAN25)
Gene Name ZSCAN25
Gene ID 221785
Synonyms
ZNF498; Zinc finger and SCAN domain-containing protein 25; Zinc finger protein 498
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSFKVSRWMGLACFRSLAASSPSIRQKKLMHKLQEEKAFREEMKIFREKIEDFREEMWT
FRGKIHAFRGQILGFWEEERPFWEEEKTFWKEEKSFWEMEKSFREEEKTFWKKYRTFWKE
DKAFWKEDNALWERDRNLLQEDKALWEEEKALWVEERALLEGEKALWEDKTSLWEEENAL
WEEERAFWMENNGHIAGEQMLEDGPHNANRGQRLLAFSRGRA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q6NSZ9
Ensemble ID
ENST00000334715.7
HGNC ID
HGNC:21961

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.I93V .
HCC827 SNV: p.A100T .
HCT15 SNV: p.R103Q; p.E379D .
MEWO SNV: p.P304S .
NALM6 SNV: p.S343A .
NCIH358 SNV: p.P268T .
OZ SNV: p.E243K .
SW1271 SNV: p.R503L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C254(0.92); C264(0.92)  LDD0078  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C144(1.19); C310(1.09)  LDD1509  [3]
 LDCM0278  AC19 HEK-293T C144(0.60); C310(1.14)  LDD1517  [3]
 LDCM0281  AC21 HEK-293T C144(1.07)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C144(0.72)  LDD1523  [3]
 LDCM0287  AC27 HEK-293T C144(0.84); C310(0.89)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C144(1.08)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C144(0.98); C310(0.98)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C144(0.96)  LDD1532  [3]
 LDCM0296  AC35 HEK-293T C144(0.93); C310(0.93)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C144(1.04)  LDD1537  [3]
 LDCM0302  AC40 HEK-293T C144(1.02)  LDD1541  [3]
 LDCM0305  AC43 HEK-293T C144(0.96); C310(1.01)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C144(0.97)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C144(0.91)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C144(1.09)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C144(1.05); C310(1.00)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C144(1.01)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C144(0.87)  LDD1558  [3]
 LDCM0322  AC59 HEK-293T C144(1.13); C310(0.99)  LDD1561  [3]
 LDCM0325  AC61 HEK-293T C144(1.20)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C144(1.03)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C144(0.88)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C144(1.00)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C144(0.91)  LDD1514  [3]
 LDCM0020  ARS-1620 HCC44 C254(0.92); C264(0.92)  LDD0078  [2]
 LDCM0369  CL100 HEK-293T C310(1.08)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C144(0.95)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C310(0.95)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C144(0.76)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C310(0.91)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C144(0.93)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C310(1.08)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C144(0.96)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C310(1.01)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C144(0.95)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C144(0.82)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C310(0.95)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C144(0.81)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C310(0.90)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C144(2.05)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C310(0.98)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C144(1.02)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C310(0.97)  LDD1607  [3]
 LDCM0406  CL19 HEK-293T C144(0.85); C310(0.94)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C144(0.78)  LDD1611  [3]
 LDCM0409  CL21 HEK-293T C144(0.97)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C144(0.78)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C144(1.10)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C310(0.90)  LDD1620  [3]
 LDCM0420  CL31 HEK-293T C144(1.22); C310(0.86)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C144(1.06)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C144(1.23)  LDD1629  [3]
 LDCM0429  CL4 HEK-293T C310(0.91)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C310(0.82)  LDD1634  [3]
 LDCM0433  CL43 HEK-293T C144(0.84); C310(1.08)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C144(0.83)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C144(0.98)  LDD1642  [3]
 LDCM0441  CL50 HEK-293T C144(0.80)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C310(0.98)  LDD1646  [3]
 LDCM0446  CL55 HEK-293T C144(0.90); C310(1.08)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C144(0.82)  LDD1651  [3]
 LDCM0452  CL60 HEK-293T C144(0.84)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C144(1.03)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C310(0.95)  LDD1659  [3]
 LDCM0459  CL67 HEK-293T C144(0.79); C310(0.96)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C144(1.12)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C144(0.99); C310(1.10)  LDD1665  [3]
 LDCM0465  CL72 HEK-293T C144(0.90)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C144(1.03)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C310(1.02)  LDD1672  [3]
 LDCM0472  CL79 HEK-293T C144(1.04); C310(1.01)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C144(0.88)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C144(0.87)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C144(0.87)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C310(1.08)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C144(1.10)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C144(1.09); C310(0.92)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C144(0.76)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C144(0.91)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C144(0.91)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C144(0.78)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C144(4.19)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C144(1.50)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C144(3.20)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402