Details of the Target

General Information of Target

Target ID LDTP15028
Target Name Rho GTPase-activating protein SYDE2 (SYDE2)
Gene Name SYDE2
Gene ID 84144
Synonyms
Rho GTPase-activating protein SYDE2; Synapse defective protein 1 homolog 2; Protein syd-1 homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPDRSKRKILKAKKTMPLSCRKQVEMLNKSRNVEALKTAIGSNVPSGNQSFSPSVITR
TTEITKCSPSENGASSLDSNKNSISEKSKVFSQNCIKPVEEIVHSETKLEQVVCSYQKPS
RTTESPSRVFTEEAKDSLNTSENDSEHQTNVTRSLFEHEGACSLKSSCCPPSVLSGVVQM
PESTVTSTVGDKKTDQMVFHLETNSNSESHDKRQSDNILCSEDSGFVPVEKTPNLVNSVT
SNNCADDILKTDECSRTSISNCESADSTWQSSLDTNNNSHYQKKRMFSENEENVKRMKTS
EQINENICVSLERQTAFLEQVRHLIQQEIYSINYELFDKKLKELNQRIGKTECRNKHEGI
ADKLLAKIAKLQRRIKTVLLFQRNCLKPNMLSSNGASKVANSEAMILDKNLESVNSPIEK
SSVNYEPSNPSEKGSKKINLSSDQNKSVSESNNDDVMLISVESPNLTTPITSNPTDTRKI
TSGNSSNSPNAEVMAVQKKLDSIIDLTKEGLSNCNTESPVSPLESHSKAASNSKETTPLA
QNAVQVPESFEHLPPLPEPPAPLPELVDKTRDTLPPQKPELKVKRVFRPNGIALTWNITK
INPKCAPVESYHLFLCHENSNNKLIWKKIGEIKALPLPMACTLSQFLASNRYYFTVQSKD
IFGRYGPFCDIKSIPGFSENLT
Target Bioclass
Other
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Uniprot ID
Q5VT97
Ensemble ID
ENST00000341460.6
HGNC ID
HGNC:25841

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.P23S .
AU565 SNV: p.N489S .
CFPAC1 SNV: p.Y1112N .
CHL1 SNV: p.G1123R .
G415 SNV: p.E639Ter .
HCC15 SNV: p.D363E .
HCT116 SNV: p.L87H .
LN229 SNV: p.D573Y .
LNCaP clone FGC SNV: p.C847Y .
MDAMB453 SNV: p.H276Q .
NB1 SNV: p.R866L .
NCIH2286 SNV: p.C704F .
SKMEL28 SNV: p.E361K .
SNU449 SNV: p.C975F .
SW620 SNV: p.P984L .
TC71 SNV: p.G13V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C856(3.34)  LDD3310  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C856(0.99)  LDD1507  [3]
 LDCM0216  AC100 HEK-293T C1095(1.08)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C1095(1.57)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C1095(0.96)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C1095(0.75)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C1095(0.97)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C1095(1.22)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C1095(1.84)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C1095(1.13)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C1095(1.46)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C1095(1.16)  LDD0823  [4]
 LDCM0227  AC110 HEK-293T C1095(0.83)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C1095(0.69)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C1095(0.68)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C1095(0.94)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C1095(0.84)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C1095(1.01)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C1095(1.11)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C1095(0.72)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C1095(0.62)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C1095(0.58)  LDD0834  [4]
 LDCM0238  AC120 HEK-293T C1095(0.82)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C1095(0.51)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C1095(0.33)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C1095(0.31)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C1095(0.53)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C1095(0.37)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C1095(0.20)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C1095(0.13)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C1095(0.88)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C1095(0.89)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C1095(0.80)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C1095(0.72)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C1095(0.89)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C1095(0.59)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C1095(0.73)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C1095(0.77)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C1095(1.61)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C1095(1.18)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C1095(0.81)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C1095(0.86)  LDD0856  [4]
 LDCM0260  AC140 HEK-293T C1095(0.86)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C1095(0.94)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C1095(0.90)  LDD0860  [4]
 LDCM0270  AC15 HEK-293T C879(1.01)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C856(1.15)  LDD1515  [3]
 LDCM0283  AC23 HEK-293T C879(0.95)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C856(1.09)  LDD1524  [3]
 LDCM0292  AC31 HEK-293T C879(1.04)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C856(1.04)  LDD1533  [3]
 LDCM0300  AC39 HEK-293T C879(1.00)  LDD1539  [3]
 LDCM0303  AC41 HEK-293T C856(1.19)  LDD1542  [3]
 LDCM0309  AC47 HEK-293T C879(1.08)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C856(1.32)  LDD1550  [3]
 LDCM0318  AC55 HEK-293T C879(1.04)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C856(1.02)  LDD1559  [3]
 LDCM0327  AC63 HEK-293T C879(1.09)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C879(1.03)  LDD1568  [3]
 LDCM0349  AC83 HEK-293T C1095(0.67)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1095(0.76)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1095(0.89)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1095(0.85)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1095(1.07)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1095(0.88)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1095(1.13)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1095(0.98)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1095(0.80)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1095(1.00)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1095(0.78)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1095(1.02)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1095(0.84)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1095(1.32)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1095(1.01)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C1095(1.07)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C1095(1.31)  LDD0964  [4]
 LDCM0356  AKOS034007680 HEK-293T C856(1.01)  LDD1570  [3]
 LDCM0372  CL103 HEK-293T C856(0.87)  LDD1576  [3]
 LDCM0376  CL107 HEK-293T C856(0.91)  LDD1580  [3]
 LDCM0379  CL11 HEK-293T C879(1.04)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C856(0.93)  LDD1585  [3]
 LDCM0385  CL115 HEK-293T C856(0.96)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C856(1.04)  LDD1593  [3]
 LDCM0394  CL123 HEK-293T C856(0.96)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C856(0.89)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C856(0.98)  LDD1606  [3]
 LDCM0404  CL17 HEK-293T C856(1.38)  LDD1608  [3]
 LDCM0411  CL23 HEK-293T C879(0.99)  LDD1615  [3]
 LDCM0415  CL27 HEK-293T C856(0.97)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C856(0.97)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C856(0.98)  LDD1622  [3]
 LDCM0424  CL35 HEK-293T C879(1.16)  LDD1628  [3]
 LDCM0428  CL39 HEK-293T C856(0.86)  LDD1632  [3]
 LDCM0431  CL41 HEK-293T C856(1.05)  LDD1635  [3]
 LDCM0437  CL47 HEK-293T C879(1.17)  LDD1641  [3]
 LDCM0440  CL5 HEK-293T C856(1.10)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C856(1.29)  LDD1647  [3]
 LDCM0450  CL59 HEK-293T C879(1.03)  LDD1653  [3]
 LDCM0455  CL63 HEK-293T C856(1.03)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C856(0.96)  LDD1660  [3]
 LDCM0464  CL71 HEK-293T C879(1.09)  LDD1667  [3]
 LDCM0470  CL77 HEK-293T C856(1.29)  LDD1673  [3]
 LDCM0477  CL83 HEK-293T C879(1.06)  LDD1680  [3]
 LDCM0481  CL87 HEK-293T C856(0.93)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C856(1.03)  LDD1686  [3]
 LDCM0490  CL95 HEK-293T C879(1.31)  LDD1693  [3]
 LDCM0494  CL99 HEK-293T C856(0.94)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C856(1.06)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C856(1.02)  LDD1671  [3]
 LDCM0022  KB02 Hs 839.T C856(3.03)  LDD2361  [1]
 LDCM0023  KB03 Hs 839.T C856(3.81)  LDD2778  [1]
 LDCM0024  KB05 COLO792 C856(3.34)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.