Details of the Target
General Information of Target
| Target ID | LDTP14898 | |||||
|---|---|---|---|---|---|---|
| Target Name | LETM1 domain-containing protein LETM2, mitochondrial (LETM2) | |||||
| Gene Name | LETM2 | |||||
| Gene ID | 137994 | |||||
| Synonyms |
LETM1 domain-containing protein LETM2, mitochondrial; LETM1 and EF-hand domain-containing protein 2; Leucine zipper-EF-hand-containing transmembrane protein 1-like |
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| 3D Structure | ||||||
| Sequence |
MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC
QAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYG AILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW LKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPS APYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYII DDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPI PAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLG ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQ QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVP PPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHM LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE VGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALT CILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMP MIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQP GTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLS SVISTTPPNL |
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| Target Bioclass |
Transporter and channel
|
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| Subcellular location |
Mitochondrion inner membrane
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CAKI1 | Deletion: p.V102Ter | DBIA Probe Info | |||
| HCT15 | SNV: p.S121Y; p.P206T | DBIA Probe Info | |||
| HT115 | SNV: p.S386P | DBIA Probe Info | |||
| SNU1 | SNV: p.C298Y | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C379(2.76) | LDD3310 | [1] | |
|
BTD Probe Info |
 |
C347(0.66) | LDD2089 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0537 | 2-Cyano-N,N-dimethylacetamide | MDA-MB-231 | C347(1.02) | LDD2130 | [2] |
| LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C347(0.80) | LDD2117 | [2] |
| LDCM0520 | AKOS000195272 | MDA-MB-231 | C347(0.57) | LDD2113 | [2] |
| LDCM0498 | BS-3668 | MDA-MB-231 | C347(0.53) | LDD2091 | [2] |
| LDCM0022 | KB02 | 22RV1 | C379(1.90) | LDD2243 | [1] |
| LDCM0023 | KB03 | 22RV1 | C379(3.02) | LDD2660 | [1] |
| LDCM0024 | KB05 | COLO792 | C379(2.76) | LDD3310 | [1] |
| LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C347(0.71) | LDD2121 | [2] |
| LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C347(0.66) | LDD2089 | [2] |
| LDCM0500 | Nucleophilic fragment 13a | MDA-MB-231 | C347(0.75) | LDD2093 | [2] |
| LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C347(0.82) | LDD2097 | [2] |
| LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C347(0.87) | LDD2099 | [2] |
| LDCM0508 | Nucleophilic fragment 17a | MDA-MB-231 | C347(1.27) | LDD2101 | [2] |
| LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C347(0.95) | LDD2107 | [2] |
| LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C347(0.68) | LDD2109 | [2] |
| LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C347(0.96) | LDD2111 | [2] |
| LDCM0526 | Nucleophilic fragment 26a | MDA-MB-231 | C347(1.18) | LDD2119 | [2] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C347(0.55) | LDD2123 | [2] |
| LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C347(0.96); C298(0.87) | LDD2125 | [2] |
| LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C347(0.94) | LDD2127 | [2] |
| LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C347(0.82) | LDD2129 | [2] |
| LDCM0540 | Nucleophilic fragment 35 | MDA-MB-231 | C347(0.66) | LDD2133 | [2] |
| LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C347(0.52) | LDD2134 | [2] |
| LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C347(0.95) | LDD2136 | [2] |
| LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C347(0.73) | LDD2140 | [2] |
| LDCM0549 | Nucleophilic fragment 43 | MDA-MB-231 | C347(0.99) | LDD2143 | [2] |
| LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C347(1.12) | LDD2144 | [2] |
| LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C347(0.84) | LDD2146 | [2] |
| LDCM0553 | Nucleophilic fragment 6b | MDA-MB-231 | C347(1.98) | LDD2147 | [2] |
| LDCM0556 | Nucleophilic fragment 8a | MDA-MB-231 | C347(1.05) | LDD2150 | [2] |
References