Details of the Target

General Information of Target

Target ID LDTP14824
Target Name ELAV-like protein 2 (ELAVL2)
Gene Name ELAVL2
Gene ID 1993
Synonyms
HUB; ELAV-like protein 2; ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTFKEAVTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGHQPFHQDTCHFL
REEKFWMMGTATQREGNSGGKIQTELESVPEAGAHEEWSCQQIWEQIAKDLTRSQDSIIN
NSQFFENGDVPSQVEAGLPTIHTGQKPSQGGKCKQSISDVPIFDLPQQLYSEEKSYTCDE
CGKSICYISALHVHQRVHVGEKLFMCDVCGKEFSQSSHLQTHQRVHTGEKPFKCEQCGKG
FSRRSALNVHRKLHTGEKPYICEACGKAFIHDSQLKEHKRIHTGEKPFKCDICGKTFYFR
SRLKSHSMVHTGEKPFRCDTCDKSFHQRSALNRHCMVHTGEKPYRCEQCGKGFIGRLDFY
KHQVVHTGEKPYNCKECGKSFRWSSCLLNHQRVHSGEKSFKCEECGKGFYTNSQLSSHQR
SHSGEKPYKCEECGKGYVTKFNLDLHQRVHTGERPYNCKECGKNFSRASSILNHKRLHCQ
KKPFKCEDCGKRLVHRTYRKDQPRDYSGENPSKCEDCGRRYKRRLNLDILLSLFLNDT
Target Bioclass
Other
Family
RRM elav family
Function RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs. Seems to recognize a GAAA motif. Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR.
Uniprot ID
Q12926
Ensemble ID
ENST00000223951.10
HGNC ID
HGNC:3313

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.Q235H .
COLO800 SNV: p.R155C .
CORL88 SNV: p.L127I .
L428 SNV: p.F170I .
MEWO SNV: p.F145V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C316(1.37)  LDD2090  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C316(0.67)  LDD2112  [1]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C316(0.79)  LDD2095  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C316(0.51)  LDD2132  [1]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C316(0.63)  LDD2131  [1]
 LDCM0545  Acetamide MDA-MB-231 C316(0.26)  LDD2138  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C316(0.64)  LDD2113  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C316(1.37)  LDD2090  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C316(0.61)  LDD2097  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C316(0.77)  LDD2098  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C316(0.67)  LDD2099  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C316(0.45)  LDD2104  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C316(0.38)  LDD2106  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C316(0.77)  LDD2107  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C316(0.46)  LDD2108  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C316(0.41)  LDD2109  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C316(0.59)  LDD2115  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C316(0.66)  LDD2116  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C316(0.81)  LDD2120  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C316(0.61)  LDD2123  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C316(0.58)  LDD2126  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C316(0.71)  LDD2127  [1]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C316(0.86)  LDD2128  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C316(0.75)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C316(0.68)  LDD2134  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C316(0.78)  LDD2137  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C316(0.45)  LDD2140  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C316(0.91)  LDD2143  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C316(0.60)  LDD2146  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gem-associated protein 8 (GEMIN8) . Q9NWZ8
Trefoil factor 2 (TFF2) . Q03403

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.