Details of the Target

General Information of Target

Target ID LDTP14711
Target Name Growth arrest-specific protein 1 (GAS1)
Gene Name GAS1
Gene ID 2619
Synonyms
Growth arrest-specific protein 1; GAS-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDR
LAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETT
LAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRN
TELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSP
LYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTD
DFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLG
GWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQ
DRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPP
ASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKE
HQETIVPVTYQLSELNQGRTWLKPCCGVFPFCLCDKEEEVSQPRGPNEKR
Target Bioclass
Other
Subcellular location
Cell membrane
Function Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Binds 20(S)-hydroxycholesterol (20(S)-OHC).
Uniprot ID
P54826
Ensemble ID
ENST00000298743.9
HGNC ID
HGNC:4165

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
OPA-S-S-alkyne
 Probe Info  		K192(1.34); K140(3.54); K137(3.54)  LDD3494  [2]
DBIA
 Probe Info  		C179(14.90)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C166(1.19)  LDD1508  [6]
 LDCM0237  AC12 HEK-293T C166(0.78)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C166(1.65)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C146(0.94)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C166(1.11)  LDD1516  [6]
 LDCM0279  AC2 HEK-293T C166(0.87)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C166(0.86)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C166(0.87); C146(0.88)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C166(1.24)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C146(0.89)  LDD1522  [6]
 LDCM0286  AC26 HEK-293T C166(1.11)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C166(0.95)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C166(0.88); C146(1.02)  LDD1528  [6]
 LDCM0291  AC30 HEK-293T C166(1.02)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C146(0.93)  LDD1531  [6]
 LDCM0295  AC34 HEK-293T C166(1.20)  LDD1534  [6]
 LDCM0297  AC36 HEK-293T C166(1.18)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C166(0.77); C146(1.00)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C166(1.32)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C146(0.99)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C166(1.06)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C166(1.17)  LDD1543  [6]
 LDCM0306  AC44 HEK-293T C166(1.09)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C166(0.83); C146(0.95)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C166(1.10)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C146(1.06)  LDD1548  [6]
 LDCM0312  AC5 HEK-293T C166(0.86); C146(1.05)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C166(1.20)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C166(1.07)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C166(0.91); C146(0.95)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C166(1.20)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C146(0.97)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C166(1.56)  LDD1560  [6]
 LDCM0323  AC6 HEK-293T C166(0.95)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C166(0.90)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C166(0.72); C146(0.96)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C166(1.39)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C146(1.00)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C146(0.93)  LDD1568  [6]
 LDCM0248  AKOS034007472 HEK-293T C166(0.90); C146(0.97)  LDD1511  [6]
 LDCM0367  CL1 HEK-293T C166(1.58); C179(1.18)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C166(1.57)  LDD1572  [6]
 LDCM0370  CL101 HEK-293T C166(1.26); C179(0.99)  LDD1574  [6]
 LDCM0374  CL105 HEK-293T C166(1.20); C179(0.91)  LDD1578  [6]
 LDCM0378  CL109 HEK-293T C166(1.04); C179(1.20)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C146(0.96)  LDD1583  [6]
 LDCM0383  CL113 HEK-293T C166(1.81); C179(1.06)  LDD1587  [6]
 LDCM0387  CL117 HEK-293T C166(1.13); C179(1.64)  LDD1591  [6]
 LDCM0392  CL121 HEK-293T C166(1.41); C179(1.11)  LDD1596  [6]
 LDCM0396  CL125 HEK-293T C166(1.26); C179(1.22)  LDD1600  [6]
 LDCM0400  CL13 HEK-293T C166(1.25); C179(1.28)  LDD1604  [6]
 LDCM0405  CL18 HEK-293T C166(1.09)  LDD1609  [6]
 LDCM0408  CL20 HEK-293T C166(1.16)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C166(1.14); C146(1.06)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C166(1.06)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C146(1.08)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C166(1.39); C179(0.84)  LDD1617  [6]
 LDCM0419  CL30 HEK-293T C166(1.17)  LDD1623  [6]
 LDCM0421  CL32 HEK-293T C166(0.99)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C166(1.46); C146(1.06)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C166(1.20)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C146(0.97)  LDD1628  [6]
 LDCM0426  CL37 HEK-293T C166(1.21); C179(1.01)  LDD1630  [6]
 LDCM0432  CL42 HEK-293T C166(1.18)  LDD1636  [6]
 LDCM0434  CL44 HEK-293T C166(0.86)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C166(0.96); C146(1.00)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C166(1.76)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C146(1.09)  LDD1641  [6]
 LDCM0439  CL49 HEK-293T C166(1.34); C179(1.14)  LDD1643  [6]
 LDCM0445  CL54 HEK-293T C166(1.36)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C166(1.19)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C166(0.81); C146(1.08)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C166(1.15)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C146(1.15)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C166(1.49)  LDD1654  [6]
 LDCM0453  CL61 HEK-293T C166(1.18); C179(0.88)  LDD1656  [6]
 LDCM0458  CL66 HEK-293T C166(1.34)  LDD1661  [6]
 LDCM0460  CL68 HEK-293T C166(1.06)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C166(0.95); C146(0.93)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C166(0.76)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C146(1.05)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C166(2.47); C179(1.08)  LDD1669  [6]
 LDCM0471  CL78 HEK-293T C166(1.26)  LDD1674  [6]
 LDCM0473  CL8 HEK-293T C166(1.32)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C166(0.96)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C166(0.94); C146(0.99)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C166(1.52)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C146(0.96)  LDD1680  [6]
 LDCM0479  CL85 HEK-293T C166(0.98); C179(0.96)  LDD1682  [6]
 LDCM0484  CL9 HEK-293T C166(1.00); C146(0.95)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C166(1.36)  LDD1688  [6]
 LDCM0487  CL92 HEK-293T C166(0.96)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C166(0.96); C146(1.00)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C166(1.22)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C146(0.96)  LDD1693  [6]
 LDCM0492  CL97 HEK-293T C166(1.85); C179(0.99)  LDD1695  [6]
 LDCM0022  KB02 EFO-27 C179(1.50)  LDD2322  [7]
 LDCM0023  KB03 Jurkat C179(14.90)  LDD0209  [3]
 LDCM0024  KB05 OVCAR-3 C179(3.76)  LDD3365  [7]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840