Details of the Target

General Information of Target

Target ID LDTP14525
Target Name Semaphorin-3D (SEMA3D)
Gene Name SEMA3D
Gene ID 223117
Synonyms
Semaphorin-3D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELENQTRVTKFILVGFPGSLSMRAAMFLIFLVAYILTVAENVIIILLVLQNRPLHKPMY
FFLANLSFLETWYISVTVPKLLFSFWSVNNSISFTLCMIQLYFFIALMCTECVLLAAMAY
DRYVAICRPLHYPTIMSHGLCFRLALGSWAIGFGISLAKIYFISCLSFCGPNVINHFFCD
ISPVLNLSCTDMSITELVDFILALVIFLFPLFITVLSYGCILATILCMPTGKQKAFSTCA
SHLVVVTIFYSAIIFMYARPRVIHAFNMNKIISIFYAIVTPSLNPFIYCLRNREVKEALK
KLAYCQASRSD
Target Bioclass
Immunoglobulin
Family
Semaphorin family
Subcellular location
Secreted
Function Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.
Uniprot ID
O95025
Ensemble ID
ENST00000284136.11
HGNC ID
HGNC:10726

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C183(1.18)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C183(1.18)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C183(1.19)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C183(1.01)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C183(1.11)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C183(0.84)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C183(1.33)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C183(0.87)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C183(0.96)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C183(0.99)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C183(0.99)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C183(0.97)  LDD1522  [1]
 LDCM0286  AC26 HEK-293T C183(1.04)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C183(1.17)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C183(0.89)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C183(1.33)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C183(1.01)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C183(0.69)  LDD1531  [1]
 LDCM0295  AC34 HEK-293T C183(1.15)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C183(1.33)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C183(0.85)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C183(1.09)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C183(1.13)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C183(1.03)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C183(1.04)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C183(1.29)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C183(1.16)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C183(1.26)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C183(0.97)  LDD1548  [1]
 LDCM0313  AC50 HEK-293T C183(1.08)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C183(1.21)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C183(1.28)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C183(1.01)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C183(0.81)  LDD1557  [1]
 LDCM0321  AC58 HEK-293T C183(1.02)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C183(1.38)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C183(1.11)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C183(0.87)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C183(0.92)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C183(0.91)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C183(1.03)  LDD1568  [1]
 LDCM0367  CL1 HEK-293T C183(1.05)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C183(1.36)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C183(1.04)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C183(1.03)  LDD1575  [1]
 LDCM0374  CL105 HEK-293T C183(0.90)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C183(0.87)  LDD1579  [1]
 LDCM0378  CL109 HEK-293T C183(1.04)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C183(1.21)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C183(1.13)  LDD1584  [1]
 LDCM0383  CL113 HEK-293T C183(1.04)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C183(1.19)  LDD1588  [1]
 LDCM0387  CL117 HEK-293T C183(1.18)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C183(1.35)  LDD1592  [1]
 LDCM0392  CL121 HEK-293T C183(1.01)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C183(1.10)  LDD1597  [1]
 LDCM0396  CL125 HEK-293T C183(1.09)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C183(1.18)  LDD1601  [1]
 LDCM0400  CL13 HEK-293T C183(1.03)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C183(1.01)  LDD1605  [1]
 LDCM0405  CL18 HEK-293T C183(1.00)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C183(1.40)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C183(0.89)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C183(0.93)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C183(0.76)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C183(0.85)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C183(1.05)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C183(0.85)  LDD1618  [1]
 LDCM0419  CL30 HEK-293T C183(1.09)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C183(2.05)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C183(0.90)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C183(0.81)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C183(0.96)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C183(1.05)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C183(1.07)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C183(1.15)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C183(1.04)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C183(0.95)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C183(1.00)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C183(1.13)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C183(0.92)  LDD1645  [1]
 LDCM0445  CL54 HEK-293T C183(2.12)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C183(1.19)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C183(1.01)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C183(1.17)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C183(0.92)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C183(1.22)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C183(1.18)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C183(0.93)  LDD1657  [1]
 LDCM0458  CL66 HEK-293T C183(1.04)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C183(1.36)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C183(1.05)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C183(1.20)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C183(1.01)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C183(1.17)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C183(1.18)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C183(1.25)  LDD1670  [1]
 LDCM0471  CL78 HEK-293T C183(0.99)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C183(1.05)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C183(1.65)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C183(1.06)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C183(0.86)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C183(1.10)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C183(0.96)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C183(0.89)  LDD1683  [1]
 LDCM0485  CL90 HEK-293T C183(1.39)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C183(1.21)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C183(0.84)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C183(1.33)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C183(1.73)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C183(1.41)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C183(1.08)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C183(0.91)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402