Details of the Target

General Information of Target

Target ID LDTP14391
Target Name ERI1 exoribonuclease 2 (ERI2)
Gene Name ERI2
Gene ID 112479
Synonyms
EXOD1; KIAA1504; ERI1 exoribonuclease 2; EC 3.1.-.-; Exonuclease domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAISPRSDATFSSQKSTPSESPRTKKFPLTEEEIFYMNCRAAYLTVFKSSLENIISKDQL
YLALQHAGRNPSQKTINKYWTPQTAKLNFDDFCIILRKEKPTSKAELLKSFKQLDVNDDG
CILHTDLYKFLTKRGEKMTREEVNAIINLADVNADGKFDYIKFCKLYMTTNEQCLKTTLE
KLEVDSKLMRHQFGNHIEGSPERDPSPVPKPSPKITRKTDPETFLNKGDTRSSLLSATRK
FKTSVSFTVTMGANGNRNSKLMEPNLIKDWQHMQSKGCFFLEEDGEIISHQYRMQIAQRS
MVYLTIKPLNLSQVEGKPSPWLSVDTALYILKENESQANLQLVCFTELRNREVFGWTGEL
GPGIYWLIPSTTGCRLRKKIKPVTDEAQLVYRDETGELFLTKEFKSTLSDIFEVIDLDGN
GLLSLEEYNFFELRTSGEKCDEDAWAVCRENFDTKRNELTRQGFMDLNLMEANDREGDPC
DLWVTLHSMGYNKALELTEACPFVIDIYAEKCKPKIKAVHMEACSGQLEKAICKSVLSNG
DAKVMDGYENIIVHTYSCDTWITSVIENKSDEKVIIHISNELSKNCINNRGLNIFAVEVG
PKSTMVCQHVMPLNERQEWIYYCIYSLIS
Target Bioclass
Enzyme
Family
ERI2 family
Uniprot ID
A8K979
Ensemble ID
ENST00000300005.7
HGNC ID
HGNC:30541

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C118(0.91)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C118(0.91)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C118(0.88)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C118(0.85)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C118(0.95)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C118(0.91)  LDD0587  [1]
 LDCM0285  AC25 HCT 116 C118(0.99)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C118(1.39)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C118(1.28)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C118(1.20)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C118(1.50)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C118(1.41)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C118(1.32)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C118(1.46)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C118(1.15)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C118(1.17)  LDD0612  [1]
 LDCM0320  AC57 HCT 116 C118(0.92)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C118(1.04)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C118(0.92)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C118(1.04)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C118(0.91)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C118(1.02)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C118(0.92)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C118(0.88)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C118(0.85)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C118(1.21)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C118(1.14)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C118(0.97)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C118(1.10)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C118(0.99)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C118(0.94)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C118(1.18)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C118(0.86)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C118(1.07)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C118(1.09)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C118(0.82)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C118(1.26)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C118(0.98)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C118(1.23)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C118(1.18)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C118(1.34)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C118(1.11)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C118(0.95)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C118(1.16)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C118(1.02)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C118(0.87)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C118(0.95)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C118(0.90)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C118(0.95)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C118(0.99)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C118(1.05)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C118(1.05)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C118(1.01)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C118(0.93)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C118(0.93)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C118(0.92)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C118(1.13)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C118(1.00)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C118(1.13)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C118(0.98)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C118(0.89)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C118(0.84)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C118(1.07)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C118(1.04)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C118(0.79)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C118(0.96)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C118(0.98)  LDD0690  [1]
 LDCM0382  CL112 HCT 116 C118(1.05)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C118(1.47)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C118(1.43)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C118(1.10)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C118(1.13)  LDD0703  [1]
 LDCM0396  CL125 HCT 116 C118(1.03)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C118(1.16)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C118(1.01)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C118(0.98)  LDD0716  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.