Details of the Target

General Information of Target

Target ID LDTP14292
Target Name IgGFc-binding protein (FCGBP)
Gene Name FCGBP
Gene ID 8857
Synonyms
IgGFc-binding protein; Fcgamma-binding protein antigen; FcgammaBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
Target Bioclass
Other
Subcellular location
Secreted
Function May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
Uniprot ID
Q9Y6R7
Ensemble ID
ENST00000628705.2
HGNC ID
HGNC:13572

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C432(3.22); C354(2.55); C228(1.34)  LDD3319  [1]
CY-1
 Probe Info  		Q1057(0.00); Q1058(0.00); Q1060(0.00)  LDD0246  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C455(0.30)  LDD1093  [4]
 LDCM0230  AC113 HEK-293T C455(0.90)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C455(0.96)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C455(1.10)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C455(1.14)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C455(0.86)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C455(1.02)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C455(0.83)  LDD0834  [4]
 LDCM0238  AC120 HEK-293T C455(1.48)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C455(0.85)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C455(0.74)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C455(0.70)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C455(1.00)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C455(0.67)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C455(0.58)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C455(0.50)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C455(0.85)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C455(1.09)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C455(0.89)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C455(0.71)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C455(0.94)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C455(0.95)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C455(1.13)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C455(0.98)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C455(0.99)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C455(0.84)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C455(0.87)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C455(0.78)  LDD0856  [4]
 LDCM0260  AC140 HEK-293T C455(1.01)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C455(0.95)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C455(0.97)  LDD0860  [4]
 LDCM0279  AC2 PaTu 8988t C455(0.32)  LDD1158  [4]
 LDCM0285  AC25 HEK-293T C455(0.80)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C455(0.84)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C455(0.82)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C455(0.77)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C455(0.84)  LDD0887  [4]
 LDCM0290  AC3 PaTu 8988t C455(0.30)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C455(0.91)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C455(0.91)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C455(0.87)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C455(0.87)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C455(0.90)  LDD0893  [4]
 LDCM0301  AC4 PaTu 8988t C455(0.26)  LDD1180  [4]
 LDCM0312  AC5 PaTu 8988t C455(0.29)  LDD1191  [4]
 LDCM0320  AC57 HEK-293T C455(1.03)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C455(1.07)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C455(0.97)  LDD0920  [4]
 LDCM0324  AC60 HEK-293T C455(1.09)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C455(0.84)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C455(0.95)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C455(0.84)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C455(0.98)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C455(0.85)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C455(1.00)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C455(0.96)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C455(0.90)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C455(0.90)  LDD0931  [4]
 LDCM0335  AC70 HEK-293T C455(1.13)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C455(1.01)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C455(1.31)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C455(1.07)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C455(0.72)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C455(0.99)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C455(0.97)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C455(1.56)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C455(0.87)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C455(0.94)  LDD0942  [4]
 LDCM0346  AC80 HEK-293T C455(1.08)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C455(1.17)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C455(1.21)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C455(1.02)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C455(1.12)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C455(1.11)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C455(1.22)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C455(1.15)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C455(1.22)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C455(1.20)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C455(1.11)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C455(1.20)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C455(1.34)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C455(1.46)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C455(1.23)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C455(1.31)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C455(1.72)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C455(1.15)  LDD0962  [4]
 LDCM0369  CL100 PaTu 8988t C455(0.32)  LDD1248  [4]
 LDCM0382  CL112 HEK-293T C455(0.81)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C455(0.81)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C455(0.74)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C455(0.88)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C455(0.92)  LDD0984  [4]
 LDCM0396  CL125 HEK-293T C455(0.91)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C455(0.94)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C455(1.13)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C455(0.98)  LDD0997  [4]
 LDCM0403  CL16 PaTu 8988t C455(1.10)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C455(1.26)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C455(1.54)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C455(1.19)  LDD1285  [4]
 LDCM0408  CL20 PaTu 8988t C455(1.90)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C455(1.44)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C455(1.38)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C455(1.87)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C455(1.73)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C455(1.42)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C455(1.58)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C455(1.58)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C455(2.84)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C455(1.80)  LDD1296  [4]
 LDCM0419  CL30 PaTu 8988t C455(1.36)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C455(1.11)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C455(2.01)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C455(1.19)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C455(1.59)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C455(1.71)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C455(1.48)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C455(2.94)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C455(1.72)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C455(1.44)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C455(1.89)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C455(1.90)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C455(3.32)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C455(1.96)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C455(1.39)  LDD1314  [4]
 LDCM0453  CL61 PaTu 8988t C455(1.07)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C455(0.78)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C455(1.00)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C455(1.00)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C455(1.06)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C455(0.89)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C455(1.14)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C455(2.09)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C455(1.68)  LDD1340  [4]
 LDCM0463  CL70 PaTu 8988t C455(1.35)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C455(0.85)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C455(0.74)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C455(1.43)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C455(1.01)  LDD1346  [4]
 LDCM0486  CL91 PaTu 8988t C455(0.22)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C455(0.24)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C455(0.22)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C455(0.18)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C455(0.25)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C455(0.19)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C455(0.19)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C455(0.21)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C455(0.21)  LDD1373  [4]
 LDCM0468  Fragment33 PaTu 8988t C455(0.84)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C455(2.79)  LDD1306  [4]
 LDCM0022  KB02 CFPAC-1 C432(2.73); C5284(2.48)  LDD2300  [1]
 LDCM0023  KB03 BxPC-3 C5284(1.74)  LDD2697  [1]
 LDCM0024  KB05 MEWO C432(3.22); C354(2.55); C228(1.34)  LDD3319  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trefoil factor 3 (TFF3) . Q07654

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.