Details of the Target

General Information of Target

Target ID LDTP13975
Target Name RING finger protein 11 (RNF11)
Gene Name RNF11
Gene ID 26994
Synonyms
RING finger protein 11
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK
AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE
YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL
Target Bioclass
Other
Subcellular location
Early endosome
Function
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Uniprot ID
Q9Y3C5
Ensemble ID
ENST00000242719.4
HGNC ID
HGNC:10056

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C125(0.94)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C125(0.94)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C117(0.95)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C117(1.09)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C125(0.89)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C117(0.68)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C117(0.97)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C125(0.87)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C125(0.73)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C117(0.91)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C117(1.34)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C125(0.83)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C117(0.77)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C117(0.98)  LDD1539  [1]
 LDCM0305  AC43 HEK-293T C125(0.97)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C117(0.86)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C117(1.50)  LDD1548  [1]
 LDCM0314  AC51 HEK-293T C125(1.01)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C117(1.07)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C117(1.07)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C125(0.69)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C117(0.90)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C117(0.92)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C117(1.01)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C117(1.06)  LDD1568  [1]
 LDCM0368  CL10 HEK-293T C117(0.51)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C117(1.12)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C117(1.24)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C117(0.82)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C117(1.04)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C117(1.10)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C117(1.05)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C117(1.27)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C117(1.13)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C117(1.12)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C117(1.25)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C117(1.41)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C117(0.92)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C117(1.00)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C117(1.22)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C117(0.87)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C117(1.00)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C117(1.04)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C117(0.79)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C117(1.08)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C117(0.96)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C117(1.16)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C117(0.85)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C117(1.04)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C117(1.08)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C117(1.16)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C117(1.19)  LDD1607  [1]
 LDCM0406  CL19 HEK-293T C125(0.76)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C117(0.96)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C117(0.81)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C117(0.95)  LDD1615  [1]
 LDCM0414  CL26 HEK-293T C117(0.86)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C117(0.88)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C117(1.25)  LDD1620  [1]
 LDCM0418  CL3 HEK-293T C117(0.88)  LDD1622  [1]
 LDCM0420  CL31 HEK-293T C125(0.80)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C117(0.76)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C117(0.95)  LDD1628  [1]
 LDCM0428  CL39 HEK-293T C117(0.80)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C117(1.55)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C117(1.00)  LDD1634  [1]
 LDCM0433  CL43 HEK-293T C125(0.96)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C117(0.98)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C117(0.95)  LDD1641  [1]
 LDCM0441  CL50 HEK-293T C117(0.93)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C117(1.40)  LDD1646  [1]
 LDCM0446  CL55 HEK-293T C125(0.61)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C117(0.93)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C117(0.76)  LDD1653  [1]
 LDCM0454  CL62 HEK-293T C117(0.91)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C117(1.09)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C117(1.41)  LDD1659  [1]
 LDCM0459  CL67 HEK-293T C125(0.75)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C125(0.79)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C117(0.86)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C117(0.86)  LDD1667  [1]
 LDCM0467  CL74 HEK-293T C117(0.82)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C117(1.60)  LDD1672  [1]
 LDCM0472  CL79 HEK-293T C125(0.86)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C117(0.86)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C117(0.78)  LDD1680  [1]
 LDCM0480  CL86 HEK-293T C117(0.98)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C117(0.73)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C117(1.29)  LDD1685  [1]
 LDCM0486  CL91 HEK-293T C125(0.70)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C117(1.26)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C117(0.89)  LDD1693  [1]
 LDCM0493  CL98 HEK-293T C117(0.75)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C117(1.17)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C117(1.12)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C117(1.00)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C117(0.79)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402