Details of the Target

General Information of Target

Target ID LDTP13757
Target Name GRB2-associated-binding protein 2 (GAB2)
Gene Name GAB2
Gene ID 9846
Synonyms
KIAA0571; GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
Target Bioclass
Other
Family
GAB family
Subcellular location
Cytoplasm
Function
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Uniprot ID
Q9UQC2
Ensemble ID
ENST00000340149.6
HGNC ID
HGNC:14458

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 Insertion: p.R354PfsTer78 .
AU565 SNV: p.E417Q .
KO52 SNV: p.Y25H .
VCAP SNV: p.M465I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C303(3.44)  LDD3332  [1]
AHL-Pu-1
 Probe Info  		C406(3.54)  LDD0171  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C406(3.54)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C303(1.02)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C303(1.07)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C303(0.99)  LDD1512  [4]
 LDCM0276  AC17 HEK-293T C303(0.99)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C303(1.13)  LDD1517  [4]
 LDCM0282  AC22 HEK-293T C303(0.97)  LDD1521  [4]
 LDCM0285  AC25 HEK-293T C303(0.96)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C303(0.95)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C303(1.04)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C303(1.17)  LDD1530  [4]
 LDCM0294  AC33 HEK-293T C303(1.07)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C303(1.06)  LDD1535  [4]
 LDCM0299  AC38 HEK-293T C303(0.96)  LDD1538  [4]
 LDCM0303  AC41 HEK-293T C303(1.10)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C303(1.14)  LDD1544  [4]
 LDCM0308  AC46 HEK-293T C303(1.05)  LDD1547  [4]
 LDCM0311  AC49 HEK-293T C303(1.05)  LDD1550  [4]
 LDCM0314  AC51 HEK-293T C303(1.09)  LDD1553  [4]
 LDCM0317  AC54 HEK-293T C303(1.09)  LDD1556  [4]
 LDCM0320  AC57 HEK-293T C303(1.06)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C303(1.02)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C303(1.06)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C303(1.00)  LDD1565  [4]
 LDCM0356  AKOS034007680 HEK-293T C303(0.99)  LDD1570  [4]
 LDCM0368  CL10 HEK-293T C303(1.38)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C303(0.81)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C303(1.20)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C303(1.02)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C303(1.24)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C303(0.91)  LDD1581  [4]
 LDCM0380  CL110 HEK-293T C303(1.24)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C303(0.90)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C303(1.30)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C303(0.87)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C303(1.23)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C303(0.94)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C303(1.10)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C303(1.05)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C303(1.05)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C303(0.78)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C303(1.19)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C303(0.97)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C303(1.21)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C303(1.41)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C303(1.08)  LDD1611  [4]
 LDCM0410  CL22 HEK-293T C303(1.31)  LDD1614  [4]
 LDCM0414  CL26 HEK-293T C303(0.96)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C303(1.14)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C303(1.21)  LDD1621  [4]
 LDCM0420  CL31 HEK-293T C303(1.25)  LDD1624  [4]
 LDCM0423  CL34 HEK-293T C303(1.33)  LDD1627  [4]
 LDCM0429  CL4 HEK-293T C303(1.14)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C303(1.01)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C303(1.11)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C303(1.23)  LDD1637  [4]
 LDCM0436  CL46 HEK-293T C303(1.24)  LDD1640  [4]
 LDCM0440  CL5 HEK-293T C303(1.11)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C303(1.23)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C303(1.09)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C303(1.29)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C303(1.41)  LDD1649  [4]
 LDCM0449  CL58 HEK-293T C303(1.20)  LDD1652  [4]
 LDCM0454  CL62 HEK-293T C303(1.19)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C303(1.10)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C303(1.07)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C303(1.44)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C303(1.61)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C303(1.14)  LDD1666  [4]
 LDCM0467  CL74 HEK-293T C303(1.16)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C303(0.83)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C303(1.10)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C303(1.33)  LDD1675  [4]
 LDCM0476  CL82 HEK-293T C303(1.26)  LDD1679  [4]
 LDCM0480  CL86 HEK-293T C303(1.11)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C303(0.91)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C303(1.16)  LDD1686  [4]
 LDCM0486  CL91 HEK-293T C303(1.25)  LDD1689  [4]
 LDCM0489  CL94 HEK-293T C303(1.15)  LDD1692  [4]
 LDCM0493  CL98 HEK-293T C303(1.08)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C303(1.16)  LDD1631  [4]
 LDCM0022  KB02 697 C303(1.36)  LDD2245  [1]
 LDCM0023  KB03 697 C303(1.66)  LDD2662  [1]
 LDCM0024  KB05 MKN45 C303(3.44)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysosomal acid phosphatase (ACP2) Histidine acid phosphatase family P11117
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) Protein-tyrosine phosphatase family Q06124
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Small ribosomal subunit protein uS2 (RPSA) Universal ribosomal protein uS2 family P08865

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402