Details of the Target

General Information of Target

Target ID LDTP13461
Target Name NTF2-related export protein 1 (NXT1)
Gene Name NXT1
Gene ID 29107
Synonyms
NTF2-related export protein 1; Protein p15
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ
LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP
DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR
DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL
ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI
LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC
ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV
NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD
SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT
TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL
PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP
LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN
LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK
QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL
PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL
HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL
SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG
AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL
NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI
LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK
EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED
FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA
PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS
ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS
LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL
LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE
IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR
ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE
GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG
Target Bioclass
Other
Subcellular location
Nucleus
Function
Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.
Uniprot ID
Q9UKK6
Ensemble ID
ENST00000254998.3
HGNC ID
HGNC:15913

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C14(1.29)  LDD2093  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Crotonaldehyde
 Probe Info  		C132(0.00); C14(0.00)  LDD0219  [5]
W1
 Probe Info  		C14(0.00); C132(0.00)  LDD0236  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C14(0.44)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C14(0.75)  LDD2112  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C14(1.31); C132(1.08)  LDD2117  [1]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C14(2.20); C132(1.44)  LDD2152  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C132(2.69)  LDD0372  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0023  KB03 MDA-MB-231 C14(1.07)  LDD1701  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C14(1.29)  LDD2093  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C14(2.31)  LDD2099  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C14(0.59); C132(0.55)  LDD2100  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C14(0.39); C132(0.76)  LDD2101  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C14(1.26); C132(1.00)  LDD2107  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C14(0.55)  LDD2108  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C14(0.65); C132(0.55)  LDD2109  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C14(0.38)  LDD2110  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C14(1.73)  LDD2111  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C14(0.65)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C14(0.32)  LDD2115  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C14(2.40); C132(1.58)  LDD2119  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C14(1.01)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C14(1.24)  LDD2125  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C14(1.03)  LDD2126  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C14(1.24)  LDD2127  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C14(1.88); C132(1.51)  LDD2129  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C14(0.34)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C132(0.44)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C14(2.46); C132(1.70)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C14(1.47)  LDD2136  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C14(1.34); C132(1.08)  LDD2140  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C14(0.92)  LDD2141  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C14(3.23); C132(2.00)  LDD2144  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C14(2.15)  LDD2145  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C14(1.14); C132(1.03)  LDD2146  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C132(0.40)  LDD2148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 3 (NXF3) NXF family Q9H4D5
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) . O95793
F-box only protein 16 (FBXO16) . Q8IX29

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625