Details of the Target

General Information of Target

Target ID LDTP13438
Target Name F-box/LRR-repeat protein 4 (FBXL4)
Gene Name FBXL4
Gene ID 26235
Synonyms
FBL4; FBL5; F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQI
ENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFT
RDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEER
QKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTK
TGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEES
AEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEH
LDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLK
TSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVW
MLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCAS
PAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVL
LFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFY
YCDNINGPHADTASGCQNLQCGFRACCRSGE
Target Bioclass
Other
Subcellular location
Cytoplasm
Uniprot ID
Q9UKA2
Ensemble ID
ENST00000229971.2
HGNC ID
HGNC:13601

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C257(1.30)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C373(1.07)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C373(1.21)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C373(1.14)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C373(1.00)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C373(1.01)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C373(1.00); C194(1.18)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C373(1.11)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C373(1.07)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C373(0.87)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C373(1.06)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C373(0.95)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C107(0.51); C373(1.06)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C373(0.91)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C373(1.01); C194(1.23)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C373(1.01)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C373(0.94)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C373(0.99)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C373(0.98)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C107(0.62); C373(1.19)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C373(1.15)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C373(1.03)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C373(1.09); C194(1.11)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C373(1.16)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C373(1.00)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C373(1.24)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C373(1.03)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C107(0.71); C373(1.21)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C373(1.00)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C373(1.12); C194(1.21)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C373(1.10)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C373(1.04)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C373(1.11)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C373(1.31)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C373(0.97)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C107(0.78); C373(1.12)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C373(1.09)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C373(1.05); C194(1.12)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C373(0.91)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C107(0.72); C373(1.31)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C373(1.00)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C373(1.28)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C373(1.01)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C107(0.60); C373(1.28)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C373(1.06)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C373(1.12); C194(1.06)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C373(1.12)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C373(1.10)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C373(1.21)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C373(1.08)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C373(0.98)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C107(0.78); C373(1.30)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C373(1.08)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C373(0.93); C194(1.07)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C373(1.06); C194(1.03)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C107(0.67); C373(1.22)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C373(1.10)  LDD1570  [2]
 LDCM0368  CL10 HEK-293T C373(1.93)  LDD1572  [2]
 LDCM0379  CL11 HEK-293T C373(1.03); C194(0.68)  LDD1583  [2]
 LDCM0404  CL17 HEK-293T C373(1.19)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C373(1.01)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C373(1.18)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C373(1.12)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C107(0.97); C373(0.98)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C373(1.19)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C373(1.06); C194(0.63)  LDD1615  [2]
 LDCM0417  CL29 HEK-293T C373(1.10)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C373(1.08)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C373(1.15)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C373(1.07)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C107(0.84); C373(1.36)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C373(1.06)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C373(1.07); C194(0.59)  LDD1628  [2]
 LDCM0431  CL41 HEK-293T C373(1.33)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C373(1.19)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C373(1.31)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C373(0.84)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C107(0.86); C373(1.49)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C373(2.09)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C373(2.79); C194(0.66)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C373(1.04)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C373(1.29)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C373(1.29)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C373(1.27)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C373(2.09)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C107(0.66); C373(2.25)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C373(1.43)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C373(1.44); C194(0.62)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C373(1.15)  LDD1654  [2]
 LDCM0457  CL65 HEK-293T C373(1.22)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C373(1.04)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C373(1.24)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C373(1.11)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C107(0.85); C373(1.66)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C373(1.28)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C373(1.15)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C373(1.04); C194(0.69)  LDD1667  [2]
 LDCM0470  CL77 HEK-293T C373(2.03)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C373(1.17)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C373(1.42)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C373(1.13)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C373(1.20)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C107(0.60); C373(1.26)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C373(1.10)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C373(1.06); C194(0.69)  LDD1680  [2]
 LDCM0483  CL89 HEK-293T C373(1.08)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C107(0.89); C373(1.32)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C373(1.00)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C373(1.25)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C373(1.31)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C107(0.86); C373(1.15)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C373(1.54)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C373(0.88); C194(0.78)  LDD1693  [2]
 LDCM0022  KB02 HCT 116 C257(1.30)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C257(1.24)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C257(1.45)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tripeptidyl-peptidase 1 (TPP1) . O14773

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402