Details of the Target

General Information of Target

Target ID LDTP12779
Target Name Centlein (CNTLN)
Gene Name CNTLN
Gene ID 54875
Synonyms
C9orf101; C9orf39; Centlein; Centrosomal protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVAY
ADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPGAVPKGNATKEYMES
LQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTM
YIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGLLFFTFTAVMFGT
QIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPTRPR
KGGPEFSV
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function Required for centrosome cohesion and recruitment of CEP68 to centrosomes.
TTD ID
T16923
Uniprot ID
Q9NXG0
DrugMap ID
TT8MI6U
Ensemble ID
ENST00000380641.4
HGNC ID
HGNC:23432

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
DBIA
 Probe Info  		C119(1.08)  LDD3373  [2]
W1
 Probe Info  		E1107(0.00); N1106(0.00)  LDD0236  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C390(0.95)  LDD1508  [4]
 LDCM0259  AC14 HEK-293T C390(1.22)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C390(0.93)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C390(0.94)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C390(1.06)  LDD1518  [4]
 LDCM0282  AC22 HEK-293T C390(1.39)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C390(0.98)  LDD1522  [4]
 LDCM0286  AC26 HEK-293T C390(1.06)  LDD1525  [4]
 LDCM0291  AC30 HEK-293T C390(0.92)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C390(1.05)  LDD1531  [4]
 LDCM0295  AC34 HEK-293T C390(0.95)  LDD1534  [4]
 LDCM0299  AC38 HEK-293T C390(1.09)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C390(0.92)  LDD1539  [4]
 LDCM0304  AC42 HEK-293T C390(0.98)  LDD1543  [4]
 LDCM0308  AC46 HEK-293T C390(1.30)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C390(1.01)  LDD1548  [4]
 LDCM0313  AC50 HEK-293T C390(0.93)  LDD1552  [4]
 LDCM0317  AC54 HEK-293T C390(1.27)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C390(0.99)  LDD1557  [4]
 LDCM0321  AC58 HEK-293T C390(0.97)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C390(1.07)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C390(1.12)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C390(1.01)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C390(1.07)  LDD1568  [4]
 LDCM0368  CL10 HEK-293T C390(1.02)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C390(0.89)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C390(1.02)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C119(0.88)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C390(1.02)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C390(0.90)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C119(1.30)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C390(0.92)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C390(1.21)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C390(0.97)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C119(0.97)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C390(0.82)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C390(1.05)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C119(1.01)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C390(0.77)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C390(1.07)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C119(1.04)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C390(0.94)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C390(1.04)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C119(1.10)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C390(0.93)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C390(1.17)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C119(1.06)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C390(1.04)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C390(1.07)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C119(0.98)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C390(0.97)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C390(1.09)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C390(1.06)  LDD1611  [4]
 LDCM0410  CL22 HEK-293T C390(1.17)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C390(1.35)  LDD1615  [4]
 LDCM0414  CL26 HEK-293T C390(1.02)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C119(1.44)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C390(0.88)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C119(1.18)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C390(1.05)  LDD1623  [4]
 LDCM0423  CL34 HEK-293T C390(1.37)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C390(1.44)  LDD1628  [4]
 LDCM0428  CL39 HEK-293T C119(0.94)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C390(1.11)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C390(0.95)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C390(1.05)  LDD1636  [4]
 LDCM0436  CL46 HEK-293T C390(1.05)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C390(1.20)  LDD1641  [4]
 LDCM0441  CL50 HEK-293T C390(1.21)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C390(1.01)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C390(1.12)  LDD1648  [4]
 LDCM0449  CL58 HEK-293T C390(1.13)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C390(1.24)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C390(1.05)  LDD1654  [4]
 LDCM0454  CL62 HEK-293T C390(1.13)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C119(0.98)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C390(0.93)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C390(1.06)  LDD1661  [4]
 LDCM0463  CL70 HEK-293T C390(1.43)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C390(1.18)  LDD1667  [4]
 LDCM0467  CL74 HEK-293T C390(1.01)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C390(0.92)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C390(1.11)  LDD1674  [4]
 LDCM0476  CL82 HEK-293T C390(1.01)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C390(1.27)  LDD1680  [4]
 LDCM0480  CL86 HEK-293T C390(1.12)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C119(0.94)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C390(0.94)  LDD1685  [4]
 LDCM0485  CL90 HEK-293T C390(0.74)  LDD1688  [4]
 LDCM0489  CL94 HEK-293T C390(0.95)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C390(0.94)  LDD1693  [4]
 LDCM0493  CL98 HEK-293T C390(1.04)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C119(0.95)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C119(1.29)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C119(0.72)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C390(0.95)  LDD1631  [4]
 LDCM0022  KB02 A-375 C228(1.71); C119(1.22)  LDD2255  [2]
 LDCM0023  KB03 A-375 C228(1.50); C119(2.40)  LDD2672  [2]
 LDCM0024  KB05 OCUG-1 C119(1.08)  LDD3373  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lung adenoma susceptibility protein 2 (LAS2) . Q8IYD9

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402