Details of the Target

General Information of Target

Target ID LDTP12722
Target Name G patch domain-containing protein 2-like (GPATCH2L)
Gene Name GPATCH2L
Gene ID 55668
Synonyms
C14orf118; KIAA1152; G patch domain-containing protein 2-like
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHITSSVFPSASLGKASSRK
PFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEEGPLDIWAVVKPGNTKEKI
AFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKVQVERMREVNSRCYQPEPF
ACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRASALLASCSKNCTNSPAIVRFSG
QSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEPVRVLDMVAKLESECLKRQGQREPG
SLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLEAPDTQVNPVGSVSVDCGPSRADRCSP
KEDQAWDGASQDCPPLPAGVSFHIDSAELEPGSQTAVKNSNRYDVEMTDELVGLPFSSHT
YSQASELPTDAVDCMSRELVSLTSRNPDQRKESLCISITVSKVDKDQPSILNSCEDPVPG
MLFFLPPGQHLSDYSQLNESTTKESSEASQLEDAAGGDSASEEKSGSAEPFVLPASSVES
TLPVLEASSWKKQVSHDFLETRFKIQQLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKC
TCCYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPY
GPGYWMCCHRSQKGFPGCKLGLHDNHWVPACHSFNRAIHKKAKGTEAEEEY
Target Bioclass
Other
Uniprot ID
Q9NWQ4
Ensemble ID
ENST00000261530.12
HGNC ID
HGNC:20210

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C274(3.34)  LDD0170  [1]
DBIA
 Probe Info  		C205(0.95)  LDD1514  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C274(3.34)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C274(2.51)  LDD0171  [1]
 LDCM0284  AC24 HEK-293T C205(0.98)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C205(0.95)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C205(0.99)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C205(0.97)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C205(0.96)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C205(0.86)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C205(0.99)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C205(0.95)  LDD1514  [2]
 LDCM0020  ARS-1620 HCC44 C408(1.22)  LDD2171  [7]
 LDCM0367  CL1 HEK-293T C395(1.05)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C395(1.04)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C395(1.26)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C395(1.11)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C395(1.10)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C395(1.07)  LDD1591  [2]
 LDCM0390  CL12 HEK-293T C205(1.00)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C395(0.92)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C395(0.73)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C395(0.96)  LDD1604  [2]
 LDCM0412  CL24 HEK-293T C205(1.07)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C395(0.71)  LDD1617  [2]
 LDCM0425  CL36 HEK-293T C205(0.98)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C395(0.89)  LDD1630  [2]
 LDCM0438  CL48 HEK-293T C205(0.93)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C395(0.92)  LDD1643  [2]
 LDCM0452  CL60 HEK-293T C205(1.00)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C395(1.02)  LDD1656  [2]
 LDCM0465  CL72 HEK-293T C205(1.26)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C395(0.97)  LDD1669  [2]
 LDCM0478  CL84 HEK-293T C205(1.00)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C395(0.74)  LDD1682  [2]
 LDCM0491  CL96 HEK-293T C205(0.87)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C395(0.98)  LDD1695  [2]
 LDCM0021  THZ1 HCT 116 C408(1.22)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
Disco-interacting protein 2 homolog A (DIP2A) DIP2 family Q14689
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger protein 263 (ZNF263) Krueppel C2H2-type zinc-finger protein family O14978
Zinc finger protein 398 (ZNF398) Krueppel C2H2-type zinc-finger protein family Q8TD17
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 547 (ZNF547) Krueppel C2H2-type zinc-finger protein family Q8IVP9
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Homeobox protein MOX-2 (MEOX2) . P50222
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Heat shock factor 2-binding protein (HSF2BP) . O75031
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
Rhombotin-1 (LMO1) . P25800
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Splicing regulator RBM11 (RBM11) . P57052
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.