Details of the Target

General Information of Target

Target ID LDTP12580
Target Name Homer protein homolog 2 (HOMER2)
Gene Name HOMER2
Gene ID 9455
Synonyms
Homer protein homolog 2; Homer-2; Cupidin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYHSFQPGSRCGSQSFSSYSAVMPRMVTHYAVSKGPCRPGGGRGLRALGCLGSRSLCNV
GFGRPRVASRCGGTLPGFGYRLGATCGPSACITPVTINESLLVPLALEIDPTVQRVKRDE
KEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRCCQTNIEPIFEGYISALRRQL
DCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCVENEFVALKKDVDTAFLMKADLE
TNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNSRELDVDGIIAEIKAQYDDIA
SRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQETENVKAQRCKL
EGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATY
RRLLEGEEHRLCEGIGPVNISVSSSKGAFLYEPCGVSTPVLSTGVLRSNGGCSIVGTGEL
YVPCEPQGLLSCGSGRKSSMTLGAGGSSPSHKH
Target Bioclass
Other
Family
Homer family
Subcellular location
Cytoplasm
Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Uniprot ID
Q9NSB8
Ensemble ID
ENST00000304231.12
HGNC ID
HGNC:17513

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C218(2.29)  LDD3493  [1]
AOyne
 Probe Info  		15.00  LDD0443  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C284(0.95)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C284(1.07)  LDD1513  [3]
 LDCM0281  AC21 HEK-293T C284(1.02); C236(0.96)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C284(1.07)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C284(1.09)  LDD1522  [3]
 LDCM0289  AC29 HEK-293T C284(0.97); C236(0.89)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C284(1.00)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C284(1.06)  LDD1531  [3]
 LDCM0298  AC37 HEK-293T C284(0.94); C236(1.18)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C284(1.06)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C284(1.11)  LDD1539  [3]
 LDCM0307  AC45 HEK-293T C284(1.02); C236(1.07)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C284(1.10)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C284(1.00)  LDD1548  [3]
 LDCM0312  AC5 HEK-293T C284(0.93); C236(0.76)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C284(0.93); C236(0.87)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C284(1.02)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C284(1.10)  LDD1557  [3]
 LDCM0323  AC6 HEK-293T C284(1.13)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C284(0.96); C236(1.24)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C284(1.01)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C284(1.11)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C284(1.05)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C284(1.04); C236(1.25)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C284(1.07)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C284(1.17)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C284(1.14)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C284(0.99)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C284(0.94)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C284(1.07)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C284(0.90)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C284(1.00)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C284(1.17)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C284(1.10)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C284(1.15)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C284(1.06)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C284(1.10)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C284(1.03)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C284(0.87)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C284(1.16)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C284(1.06)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C284(1.01)  LDD1592  [3]
 LDCM0391  CL120 HEK-293T C284(1.14)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C284(1.05)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C284(1.01)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C284(1.20)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C284(1.23)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C284(1.16)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C284(1.25)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C284(1.32)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C284(1.10)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C284(1.30)  LDD1607  [3]
 LDCM0407  CL2 HEK-293T C284(1.11)  LDD1611  [3]
 LDCM0409  CL21 HEK-293T C284(1.06); C236(1.31)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C284(1.14)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C284(1.03)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C284(1.10)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C284(1.01)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C284(1.09)  LDD1620  [3]
 LDCM0422  CL33 HEK-293T C284(1.05); C236(1.17)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C284(1.11)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C284(1.00)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C284(1.09)  LDD1630  [3]
 LDCM0429  CL4 HEK-293T C284(1.24)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C284(1.06)  LDD1634  [3]
 LDCM0435  CL45 HEK-293T C284(1.04); C236(2.15)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C284(1.02)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C284(1.02)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C284(1.05)  LDD1643  [3]
 LDCM0441  CL50 HEK-293T C284(1.04)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C284(1.27)  LDD1646  [3]
 LDCM0448  CL57 HEK-293T C284(1.09); C236(0.95)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C284(1.09)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C284(0.98)  LDD1653  [3]
 LDCM0453  CL61 HEK-293T C284(1.06)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C284(0.96)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C284(1.24)  LDD1659  [3]
 LDCM0461  CL69 HEK-293T C284(0.84); C236(1.01)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C284(0.93)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C284(1.04)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C284(0.96)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C284(1.01)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C284(1.22)  LDD1672  [3]
 LDCM0475  CL81 HEK-293T C284(0.89); C236(1.53)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C284(1.00)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C284(0.99)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C284(1.15)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C284(1.12)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C284(1.19)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C284(1.05); C236(1.29)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C284(1.09); C236(1.58)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C284(1.01)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C284(1.01)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C284(1.15)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C284(1.07)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C284(0.97)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C284(1.00); C236(1.10)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C284(0.96); C236(1.10)  LDD1497  [3]
 LDCM0024  KB05 ZR-75-1 C218(2.29)  LDD3493  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402