Details of the Target

General Information of Target

Target ID LDTP12553
Target Name Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1)
Gene Name C1GALT1
Gene ID 56913
Synonyms
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; EC 2.4.1.122; B3Gal-T8; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAERPAGSGGSEAPAMVEQLDTAVITPAMLEEEEQLEAAGLERERKMLEKARMSWDRES
TEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLERKKESLKVKKGKNSIDASE
EKPVMRKKRGREDESYNISEVMSKEEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSN
SIIKDRLSETVRQNTKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWEN
GINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPDIPTM
LYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEGHRIK
NMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSL
SETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLSKKQEIFY
TAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEKLISQIQPEVD
RERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEFKIDEELVTNSGK
FLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHS
FNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVY
RLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLNLSKNFLDPKELMELLKSRDY
EREIKGSREKVISDKDLELLLDRSDLIDQMNASGPIKEKMGIFKILENSEDSSPECLF
Target Bioclass
Enzyme
Family
Glycosyltransferase 31 family, Beta3-Gal-T subfamily
Subcellular location
Membrane
Function
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
Uniprot ID
Q9NS00
Ensemble ID
ENST00000223122.4
HGNC ID
HGNC:24337
ChEMBL ID
CHEMBL2321633

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.R49G .
IGROV1 SNV: p.D355G .
Ishikawa (Heraklio) 02 ER SNV: p.G195E .
MFE319 SNV: p.Q38Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.71  LDD0318  [1]
DBIA
 Probe Info  		C232(0.83)  LDD1514  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C232(1.26)  LDD1523  [2]
 LDCM0293  AC32 HEK-293T C232(1.09)  LDD1532  [2]
 LDCM0302  AC40 HEK-293T C232(0.98)  LDD1541  [2]
 LDCM0310  AC48 HEK-293T C232(0.98)  LDD1549  [2]
 LDCM0319  AC56 HEK-293T C232(1.00)  LDD1558  [2]
 LDCM0328  AC64 HEK-293T C232(1.06)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C232(0.87)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C232(0.83)  LDD1514  [2]
 LDCM0390  CL12 HEK-293T C232(1.02)  LDD1594  [2]
 LDCM0412  CL24 HEK-293T C232(0.95)  LDD1616  [2]
 LDCM0425  CL36 HEK-293T C232(1.10)  LDD1629  [2]
 LDCM0438  CL48 HEK-293T C232(1.05)  LDD1642  [2]
 LDCM0452  CL60 HEK-293T C232(1.59)  LDD1655  [2]
 LDCM0465  CL72 HEK-293T C232(0.85)  LDD1668  [2]
 LDCM0478  CL84 HEK-293T C232(1.01)  LDD1681  [2]
 LDCM0491  CL96 HEK-293T C232(0.74)  LDD1694  [2]
 LDCM0022  KB02 ICC10 C232(2.03)  LDD2379  [3]
 LDCM0023  KB03 ICC10 C232(2.25)  LDD2796  [3]
 LDCM0024  KB05 ICC10 C232(2.18)  LDD3213  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C1GALT1-specific chaperone 1 (C1GALT1C1) Glycosyltransferase 31 family Q96EU7

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840