Details of the Target

General Information of Target

Target ID LDTP12357
Target Name Arf-GAP with dual PH domain-containing protein 2 (ADAP2)
Gene Name ADAP2
Gene ID 55803
Synonyms
CENTA2; Arf-GAP with dual PH domain-containing protein 2; Centaurin-alpha-2; Cnt-a2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEG
DEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSP
VGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVF
AHGAATLSP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Uniprot ID
Q9NPF8
Ensemble ID
ENST00000330889.8
HGNC ID
HGNC:16487

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.D27N .
HEC1 SNV: p.V51I .
HEC1B SNV: p.V51I .
U2OS SNV: p.S72G .
YSCCC Deletion: p.H196MfsTer26 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C282(1.13)  LDD0593  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0246  AC128 HEK-293T C282(0.92)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C282(0.87)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C282(0.86)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C282(0.91)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C282(0.87)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C282(1.10)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C282(1.04)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C282(1.09)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C282(1.02)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C282(1.05)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C282(1.36)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C282(1.09)  LDD0856  [1]
 LDCM0260  AC140 HEK-293T C282(0.89)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C282(1.06)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C282(0.95)  LDD0860  [1]
 LDCM0276  AC17 HCT 116 C282(1.13)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C282(1.12)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C282(1.20)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C282(1.19)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C282(1.14)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C282(0.98)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C282(1.08)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C282(1.04)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C282(1.14)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C282(1.36)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C282(1.52)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C282(1.38)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C282(1.26)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C282(1.32)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C282(1.53)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C282(1.62)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C282(1.61)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C282(1.92)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C282(0.69)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C282(0.86)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C282(0.80)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C282(0.89)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C282(1.00)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C282(1.14)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C282(0.78)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C282(0.95)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C282(0.90)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C282(0.96)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C282(1.03)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C282(1.07)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C282(1.34)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C282(0.98)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C282(0.95)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C343(1.03)  LDD1551  [2]
 LDCM0313  AC50 HCT 116 C282(1.24)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C282(1.06)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C282(1.19)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C282(0.94)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C282(1.09)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C282(1.15)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C282(1.06)  LDD0636  [1]
 LDCM0325  AC61 HEK-293T C343(1.00)  LDD1564  [2]
 LDCM0248  AKOS034007472 HEK-293T C343(0.97)  LDD1511  [2]
 LDCM0371  CL102 HEK-293T C343(0.96)  LDD1575  [2]
 LDCM0374  CL105 HCT 116 C282(1.50)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C282(1.74)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C282(1.74)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C282(1.80)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C282(1.21)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C282(1.54)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C282(1.16)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C282(1.36)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C282(1.69)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C282(1.62)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C282(1.52)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C282(1.54)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C282(1.55)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C282(0.99)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C282(0.84)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C282(0.84)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C282(0.94)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C282(0.89)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C282(1.10)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C282(1.10)  LDD0712  [1]
 LDCM0397  CL126 HEK-293T C343(1.04)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C343(1.08)  LDD1605  [2]
 LDCM0407  CL2 HEK-293T C343(1.03)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C343(1.13)  LDD1613  [2]
 LDCM0414  CL26 HEK-293T C343(0.95)  LDD1618  [2]
 LDCM0422  CL33 HEK-293T C343(1.39)  LDD1626  [2]
 LDCM0435  CL45 HEK-293T C343(1.10)  LDD1639  [2]
 LDCM0441  CL50 HEK-293T C343(1.00)  LDD1645  [2]
 LDCM0448  CL57 HEK-293T C343(1.00)  LDD1651  [2]
 LDCM0453  CL61 HEK-293T C282(1.28)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C282(1.00)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C282(1.34)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C282(1.09)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C282(1.18)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C282(1.03)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C282(0.97)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C282(0.86)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C282(1.18)  LDD1059  [1]
 LDCM0463  CL70 HEK-293T C282(1.12)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C282(0.88)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C282(0.96)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C282(0.89)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C282(1.15)  LDD1065  [1]
 LDCM0475  CL81 HEK-293T C343(1.02)  LDD1678  [2]
 LDCM0480  CL86 HEK-293T C343(1.08)  LDD1683  [2]
 LDCM0484  CL9 HEK-293T C343(1.03)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C343(1.18)  LDD1691  [2]
 LDCM0493  CL98 HEK-293T C343(1.06)  LDD1696  [2]
 LDCM0468  Fragment33 HEK-293T C282(1.14)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C343(0.97)  LDD1631  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402