Details of the Target

General Information of Target

Target ID LDTP12284
Target Name O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS)
Gene Name SEPSECS
Gene ID 51091
Synonyms
TRNP48; O-phosphoseryl-tRNA(Sec) selenium transferase; EC 2.9.1.2; Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIH
RSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKK
WGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWR
KQLVQAFLSCLLTTAFIYLWTRLL
Target Bioclass
Enzyme
Family
SepSecS family
Subcellular location
Cytoplasm
Function Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Uniprot ID
Q9HD40
Ensemble ID
ENST00000382103.7
HGNC ID
HGNC:30605

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.R156Ter .
NCIH358 Insertion: p.S111_S112dup DBIA    Probe Info 
PF382 SNV: p.L31P DBIA    Probe Info 
SW620 SNV: p.E206K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y473(34.43)  LDD3495  [1]
DBIA
 Probe Info  		C22(2.38)  LDD3332  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C262(0.00); C431(0.00); C219(0.00); C226(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C216(1.21)  LDD1523  [4]
 LDCM0293  AC32 HEK-293T C216(1.32)  LDD1532  [4]
 LDCM0302  AC40 HEK-293T C216(1.37)  LDD1541  [4]
 LDCM0310  AC48 HEK-293T C216(0.90)  LDD1549  [4]
 LDCM0319  AC56 HEK-293T C216(1.20)  LDD1558  [4]
 LDCM0328  AC64 HEK-293T C216(1.28)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C216(1.41)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C216(1.17)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C216(0.79)  LDD1571  [4]
 LDCM0369  CL100 HEK-293T C216(1.00)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C216(1.00)  LDD1574  [4]
 LDCM0373  CL104 HEK-293T C216(0.98)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C216(1.27)  LDD1578  [4]
 LDCM0377  CL108 HEK-293T C216(0.90)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C216(0.94)  LDD1582  [4]
 LDCM0382  CL112 HEK-293T C216(1.01)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C216(1.14)  LDD1587  [4]
 LDCM0386  CL116 HEK-293T C216(1.22)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C216(0.67)  LDD1591  [4]
 LDCM0390  CL12 HEK-293T C216(1.14)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C216(0.82)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C216(1.17)  LDD1596  [4]
 LDCM0395  CL124 HEK-293T C216(0.71)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C216(1.17)  LDD1600  [4]
 LDCM0399  CL128 HEK-293T C216(0.96)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C216(0.87)  LDD1604  [4]
 LDCM0403  CL16 HEK-293T C216(0.84)  LDD1607  [4]
 LDCM0412  CL24 HEK-293T C216(1.41)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C216(1.27)  LDD1617  [4]
 LDCM0416  CL28 HEK-293T C216(1.16)  LDD1620  [4]
 LDCM0425  CL36 HEK-293T C216(1.47)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C216(0.97)  LDD1630  [4]
 LDCM0429  CL4 HEK-293T C216(0.87)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C216(1.16)  LDD1634  [4]
 LDCM0438  CL48 HEK-293T C216(1.49)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C216(0.94)  LDD1643  [4]
 LDCM0443  CL52 HEK-293T C216(0.92)  LDD1646  [4]
 LDCM0452  CL60 HEK-293T C216(0.95)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C216(1.05)  LDD1656  [4]
 LDCM0456  CL64 HEK-293T C216(0.95)  LDD1659  [4]
 LDCM0465  CL72 HEK-293T C216(1.08)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C216(0.92)  LDD1669  [4]
 LDCM0469  CL76 HEK-293T C216(0.96)  LDD1672  [4]
 LDCM0478  CL84 HEK-293T C216(1.15)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C216(0.82)  LDD1682  [4]
 LDCM0482  CL88 HEK-293T C216(0.96)  LDD1685  [4]
 LDCM0491  CL96 HEK-293T C216(0.91)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C216(0.93)  LDD1695  [4]
 LDCM0022  KB02 697 C22(1.58)  LDD2245  [2]
 LDCM0023  KB03 697 C22(3.05)  LDD2662  [2]
 LDCM0024  KB05 MKN45 C22(2.38)  LDD3332  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyridoxal Phosphate Small molecular drug DB00114

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402