Details of the Target

General Information of Target

Target ID LDTP12271
Target Name Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2)
Gene Name CELSR2
Gene ID 1952
Synonyms
CDHF10; EGFL2; KIAA0279; MEGF3; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; Epidermal growth factor-like protein 2; EGF-like protein 2; Flamingo homolog 3; Multiple epidermal growth factor-like domains protein 3; Multiple EGF-like domains protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLAT
PRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQP
ASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYT
TPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNG
GCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGF
RPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQA
SQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREP
QIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDH
QIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAG
TQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPV
SPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLP
SPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNK
RITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, LN-TM7 subfamily
Subcellular location
Cell membrane
Function Receptor that may have an important role in cell/cell signaling during nervous system formation.
Uniprot ID
Q9HCU4
Ensemble ID
ENST00000271332.4
HGNC ID
HGNC:3231

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K2300(1.18); K2001(1.50); K2121(2.98); K1846(3.09)  LDD3494  [1]
DBIA
 Probe Info  		C1761(3.08); C2861(2.07); C1307(2.74)  LDD3368  [2]
AHL-Pu-1
 Probe Info  		C2646(3.09)  LDD0172  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		C2843(0.00); C2861(0.00); C2646(0.00)  LDD0147  [5]
W1
 Probe Info  		N.A.  LDD0236  [6]
NAIA_5
 Probe Info  		C1323(0.00); C1999(0.00); C1761(0.00); C1545(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C2646(3.09)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2646(2.01)  LDD0372  [3]
 LDCM0214  AC1 HEK-293T C2843(0.99); C2861(1.21)  LDD1507  [8]
 LDCM0226  AC11 HEK-293T C2843(0.97)  LDD1509  [8]
 LDCM0270  AC15 HEK-293T C2843(1.08)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C2843(1.01); C2861(1.19)  LDD1515  [8]
 LDCM0278  AC19 HEK-293T C2843(1.45)  LDD1517  [8]
 LDCM0283  AC23 HEK-293T C2843(0.95)  LDD1522  [8]
 LDCM0285  AC25 HEK-293T C2843(0.99); C2861(1.07)  LDD1524  [8]
 LDCM0287  AC27 HEK-293T C2843(1.03)  LDD1526  [8]
 LDCM0290  AC3 HEK-293T C2843(0.99)  LDD1529  [8]
 LDCM0292  AC31 HEK-293T C2843(1.03)  LDD1531  [8]
 LDCM0294  AC33 HEK-293T C2843(1.00); C2861(0.99)  LDD1533  [8]
 LDCM0296  AC35 HEK-293T C2843(1.00)  LDD1535  [8]
 LDCM0300  AC39 HEK-293T C2843(1.04)  LDD1539  [8]
 LDCM0303  AC41 HEK-293T C2843(0.95); C2861(1.11)  LDD1542  [8]
 LDCM0305  AC43 HEK-293T C2843(0.99)  LDD1544  [8]
 LDCM0309  AC47 HEK-293T C2843(0.95)  LDD1548  [8]
 LDCM0311  AC49 HEK-293T C2843(1.03); C2861(1.14)  LDD1550  [8]
 LDCM0314  AC51 HEK-293T C2843(0.96)  LDD1553  [8]
 LDCM0318  AC55 HEK-293T C2843(0.96)  LDD1557  [8]
 LDCM0320  AC57 HEK-293T C2843(1.06); C2861(1.02)  LDD1559  [8]
 LDCM0322  AC59 HEK-293T C2843(1.02)  LDD1561  [8]
 LDCM0327  AC63 HEK-293T C2843(1.02)  LDD1566  [8]
 LDCM0334  AC7 HEK-293T C2843(1.04)  LDD1568  [8]
 LDCM0356  AKOS034007680 HEK-293T C2843(1.03); C2861(1.20)  LDD1570  [8]
 LDCM0632  CL-Sc Hep-G2 C2861(20.00); C2861(0.32)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C1337(0.89)  LDD1571  [8]
 LDCM0370  CL101 HEK-293T C1337(0.91)  LDD1574  [8]
 LDCM0372  CL103 HEK-293T C1337(1.01)  LDD1576  [8]
 LDCM0374  CL105 HEK-293T C1337(1.00)  LDD1578  [8]
 LDCM0376  CL107 HEK-293T C1337(0.87)  LDD1580  [8]
 LDCM0378  CL109 HEK-293T C1337(0.94)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C2843(1.23)  LDD1583  [8]
 LDCM0381  CL111 HEK-293T C1337(0.85)  LDD1585  [8]
 LDCM0383  CL113 HEK-293T C1337(0.97)  LDD1587  [8]
 LDCM0385  CL115 HEK-293T C1337(0.91)  LDD1589  [8]
 LDCM0387  CL117 HEK-293T C1337(1.04)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C1337(1.02)  LDD1593  [8]
 LDCM0392  CL121 HEK-293T C1337(0.99)  LDD1596  [8]
 LDCM0394  CL123 HEK-293T C1337(1.13)  LDD1598  [8]
 LDCM0396  CL125 HEK-293T C1337(0.83)  LDD1600  [8]
 LDCM0398  CL127 HEK-293T C1337(0.88)  LDD1602  [8]
 LDCM0400  CL13 HEK-293T C1337(0.91)  LDD1604  [8]
 LDCM0402  CL15 HEK-293T C1337(0.90)  LDD1606  [8]
 LDCM0404  CL17 HEK-293T C2843(0.94); C2861(1.50)  LDD1608  [8]
 LDCM0406  CL19 HEK-293T C2843(0.99)  LDD1610  [8]
 LDCM0411  CL23 HEK-293T C2843(1.33)  LDD1615  [8]
 LDCM0413  CL25 HEK-293T C1337(0.92)  LDD1617  [8]
 LDCM0415  CL27 HEK-293T C1337(0.79)  LDD1619  [8]
 LDCM0417  CL29 HEK-293T C2843(1.10); C2861(0.94)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C1337(1.09)  LDD1622  [8]
 LDCM0420  CL31 HEK-293T C2843(1.06)  LDD1624  [8]
 LDCM0424  CL35 HEK-293T C2843(1.13)  LDD1628  [8]
 LDCM0426  CL37 HEK-293T C1337(0.81)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C1337(0.94)  LDD1632  [8]
 LDCM0431  CL41 HEK-293T C2843(1.11); C2861(1.00)  LDD1635  [8]
 LDCM0433  CL43 HEK-293T C2843(0.97)  LDD1637  [8]
 LDCM0437  CL47 HEK-293T C2843(1.05)  LDD1641  [8]
 LDCM0439  CL49 HEK-293T C1337(1.19)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C2843(1.01); C2861(1.17)  LDD1644  [8]
 LDCM0444  CL53 HEK-293T C2843(1.07); C2861(0.98)  LDD1647  [8]
 LDCM0446  CL55 HEK-293T C2843(1.06)  LDD1649  [8]
 LDCM0450  CL59 HEK-293T C2843(1.13)  LDD1653  [8]
 LDCM0453  CL61 HEK-293T C1337(1.02)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C1337(1.08)  LDD1658  [8]
 LDCM0457  CL65 HEK-293T C2843(1.06); C2861(1.21)  LDD1660  [8]
 LDCM0459  CL67 HEK-293T C2843(1.07)  LDD1662  [8]
 LDCM0462  CL7 HEK-293T C2843(1.01)  LDD1665  [8]
 LDCM0464  CL71 HEK-293T C2843(1.21)  LDD1667  [8]
 LDCM0466  CL73 HEK-293T C1337(1.01)  LDD1669  [8]
 LDCM0470  CL77 HEK-293T C2843(1.08); C2861(0.95)  LDD1673  [8]
 LDCM0472  CL79 HEK-293T C2843(1.06)  LDD1675  [8]
 LDCM0477  CL83 HEK-293T C2843(1.16)  LDD1680  [8]
 LDCM0479  CL85 HEK-293T C1337(0.88)  LDD1682  [8]
 LDCM0481  CL87 HEK-293T C1337(0.93)  LDD1684  [8]
 LDCM0483  CL89 HEK-293T C2843(1.01); C2861(1.15)  LDD1686  [8]
 LDCM0486  CL91 HEK-293T C2843(1.06)  LDD1689  [8]
 LDCM0490  CL95 HEK-293T C2843(1.10)  LDD1693  [8]
 LDCM0492  CL97 HEK-293T C1337(0.94)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C1337(0.83)  LDD1697  [8]
 LDCM0634  CY-0357 Hep-G2 C2843(0.64)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C1337(1.00)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C1337(0.87)  LDD1671  [8]
 LDCM0022  KB02 A2058 C2861(1.72); C1620(3.01)  LDD2253  [2]
 LDCM0023  KB03 A2058 C2861(1.34); C1620(4.70)  LDD2670  [2]
 LDCM0024  KB05 OAW-28 C1761(3.08); C2861(2.07); C1307(2.74)  LDD3368  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402