Details of the Target

General Information of Target

Target ID LDTP12225
Target Name Serine/threonine-protein kinase Nek6 (NEK6)
Gene Name NEK6
Gene ID 10783
Synonyms
Serine/threonine-protein kinase Nek6; EC 2.7.11.34; Never in mitosis A-related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMT
NLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRH
PLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGF
YLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVR
LAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKS
QDSLCVTLA
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Subcellular location
Cytoplasm
Function
Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression.
TTD ID
T30829
Uniprot ID
Q9HC98
DrugMap ID
TTHOI91
Ensemble ID
ENST00000320246.10
HGNC ID
HGNC:7749
ChEMBL ID
CHEMBL4309

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.V208L DBIA    Probe Info 
HEC1B SNV: p.V208L .
HT115 SNV: p.R53Q .
LNCaP clone FGC Deletion: p.P268HfsTer74 .
MFE319 SNV: p.L257M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K98(8.44)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
m-APA
 Probe Info  		13.37  LDD0403  [3]
BTD
 Probe Info  		C90(0.41)  LDD2091  [4]
AHL-Pu-1
 Probe Info  		C258(6.18)  LDD0170  [5]
DBIA
 Probe Info  		C258(113.05); C64(17.02)  LDD0209  [6]
IA-alkyne
 Probe Info  		C64(13.93)  LDD1705  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
NPM
 Probe Info  		N.A.  LDD0016  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C258(6.18)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C258(2.24)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C235(1.07)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C40(1.09)  LDD1508  [11]
 LDCM0237  AC12 HEK-293T C40(1.00)  LDD1510  [11]
 LDCM0270  AC15 HEK-293T C40(1.31)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C235(1.02)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C40(1.19)  LDD1516  [11]
 LDCM0279  AC2 HEK-293T C40(1.08)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C40(0.95)  LDD1519  [11]
 LDCM0283  AC23 HEK-293T C40(0.97)  LDD1522  [11]
 LDCM0285  AC25 HEK-293T C235(1.12)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C40(1.14)  LDD1525  [11]
 LDCM0288  AC28 HEK-293T C40(1.02)  LDD1527  [11]
 LDCM0292  AC31 HEK-293T C40(1.00)  LDD1531  [11]
 LDCM0294  AC33 HEK-293T C235(1.19)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C40(1.03)  LDD1534  [11]
 LDCM0297  AC36 HEK-293T C40(1.10)  LDD1536  [11]
 LDCM0300  AC39 HEK-293T C40(1.21)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C40(0.87)  LDD1540  [11]
 LDCM0303  AC41 HEK-293T C235(1.36)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C40(1.22)  LDD1543  [11]
 LDCM0306  AC44 HEK-293T C40(1.18)  LDD1545  [11]
 LDCM0309  AC47 HEK-293T C40(1.08)  LDD1548  [11]
 LDCM0311  AC49 HEK-293T C235(1.17)  LDD1550  [11]
 LDCM0313  AC50 HEK-293T C40(1.40)  LDD1552  [11]
 LDCM0315  AC52 HEK-293T C40(1.05)  LDD1554  [11]
 LDCM0318  AC55 HEK-293T C40(1.03)  LDD1557  [11]
 LDCM0320  AC57 HEK-293T C235(1.02)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C40(1.05)  LDD1560  [11]
 LDCM0324  AC60 HEK-293T C40(1.04)  LDD1563  [11]
 LDCM0327  AC63 HEK-293T C40(1.15)  LDD1566  [11]
 LDCM0334  AC7 HEK-293T C40(1.06)  LDD1568  [11]
 LDCM0356  AKOS034007680 HEK-293T C235(1.00)  LDD1570  [11]
 LDCM0156  Aniline NCI-H1299 13.37  LDD0403  [3]
 LDCM0498  BS-3668 MDA-MB-231 C90(0.41)  LDD2091  [4]
 LDCM0367  CL1 HEK-293T C264(1.30); C235(1.22)  LDD1571  [11]
 LDCM0370  CL101 HEK-293T C264(0.95); C235(1.02)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C40(1.13)  LDD1575  [11]
 LDCM0374  CL105 HEK-293T C264(0.93); C235(0.90)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C40(0.99)  LDD1579  [11]
 LDCM0378  CL109 HEK-293T C264(1.41); C235(1.03)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C40(1.01)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C40(0.99)  LDD1584  [11]
 LDCM0383  CL113 HEK-293T C264(0.94); C235(1.17)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C40(1.29)  LDD1588  [11]
 LDCM0387  CL117 HEK-293T C264(0.83); C235(0.96)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C40(1.42)  LDD1592  [11]
 LDCM0392  CL121 HEK-293T C264(0.89); C235(1.23)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C40(1.22)  LDD1597  [11]
 LDCM0396  CL125 HEK-293T C264(0.53); C235(0.85)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C40(1.29)  LDD1601  [11]
 LDCM0400  CL13 HEK-293T C264(1.18); C235(0.93)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C40(1.22)  LDD1605  [11]
 LDCM0404  CL17 HEK-293T C235(1.02)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C40(1.15)  LDD1609  [11]
 LDCM0407  CL2 HEK-293T C40(1.25)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C40(1.17)  LDD1612  [11]
 LDCM0411  CL23 HEK-293T C40(1.10)  LDD1615  [11]
 LDCM0413  CL25 HEK-293T C264(1.52); C235(0.89)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C40(1.15)  LDD1618  [11]
 LDCM0417  CL29 HEK-293T C235(1.20)  LDD1621  [11]
 LDCM0419  CL30 HEK-293T C40(1.02)  LDD1623  [11]
 LDCM0421  CL32 HEK-293T C40(0.99)  LDD1625  [11]
 LDCM0424  CL35 HEK-293T C40(1.07)  LDD1628  [11]
 LDCM0426  CL37 HEK-293T C264(0.87); C235(1.06)  LDD1630  [11]
 LDCM0431  CL41 HEK-293T C235(0.96)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C40(1.07)  LDD1636  [11]
 LDCM0434  CL44 HEK-293T C40(1.10)  LDD1638  [11]
 LDCM0437  CL47 HEK-293T C40(1.32)  LDD1641  [11]
 LDCM0439  CL49 HEK-293T C264(0.94); C235(0.95)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C235(1.22)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C40(1.12)  LDD1645  [11]
 LDCM0444  CL53 HEK-293T C235(0.95)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C40(1.32)  LDD1648  [11]
 LDCM0447  CL56 HEK-293T C40(0.99)  LDD1650  [11]
 LDCM0450  CL59 HEK-293T C40(1.35)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C40(1.20)  LDD1654  [11]
 LDCM0453  CL61 HEK-293T C264(1.14); C235(0.85)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C40(1.35)  LDD1657  [11]
 LDCM0457  CL65 HEK-293T C235(0.92)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C40(1.01)  LDD1661  [11]
 LDCM0460  CL68 HEK-293T C40(1.08)  LDD1663  [11]
 LDCM0464  CL71 HEK-293T C40(1.33)  LDD1667  [11]
 LDCM0466  CL73 HEK-293T C264(1.05); C235(1.25)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C40(1.24)  LDD1670  [11]
 LDCM0470  CL77 HEK-293T C235(1.48)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C40(1.08)  LDD1674  [11]
 LDCM0473  CL8 HEK-293T C40(1.35)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C40(0.92)  LDD1677  [11]
 LDCM0477  CL83 HEK-293T C40(1.14)  LDD1680  [11]
 LDCM0479  CL85 HEK-293T C264(0.92); C235(0.90)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C40(1.10)  LDD1683  [11]
 LDCM0483  CL89 HEK-293T C235(0.97)  LDD1686  [11]
 LDCM0485  CL90 HEK-293T C40(1.19)  LDD1688  [11]
 LDCM0487  CL92 HEK-293T C40(1.09)  LDD1690  [11]
 LDCM0490  CL95 HEK-293T C40(1.10)  LDD1693  [11]
 LDCM0492  CL97 HEK-293T C264(0.79); C235(0.90)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C40(1.12)  LDD1696  [11]
 LDCM0427  Fragment51 HEK-293T C40(1.14)  LDD1631  [11]
 LDCM0022  KB02 769-P C98(2.57); C292(1.75)  LDD2246  [12]
 LDCM0023  KB03 Jurkat C258(113.05); C64(17.02)  LDD0209  [6]
 LDCM0024  KB05 G361 C98(3.08)  LDD3311  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C64(1.55)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C64(1.22)  LDD2109  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C64(1.11)  LDD2115  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C64(0.97)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C64(1.12)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C64(1.22)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C64(0.65)  LDD2137  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Tudor-interacting repair regulator protein (NUDT16L1) Nudix hydrolase family Q9BRJ7
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) AGC Ser/Thr protein kinase family P51812
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Activated CDC42 kinase 1 (TNK2) Tyr protein kinase family Q07912
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) SH3RF family Q8TEC5
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B6 (HOXB6) Antp homeobox family P17509
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Forkhead box protein J3 (FOXJ3) . Q9UPW0
Myogenin (MYOG) . P15173
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 39 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Cyclin-dependent kinase 5 activator 1 (CDK5R1) Cyclin-dependent kinase 5 activator family Q15078
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2) DPH1/DPH2 family Q9BQC3
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Protein INCA1 (INCA1) INCA family Q0VD86
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Keratin, type II cytoskeletal 8 (KRT8) Intermediate filament family P05787
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
KATNB1-like protein 1 (KATNBL1) . Q9H079
PRKCA-binding protein (PICK1) . Q9NRD5
Properdin (CFP) . P27918
Protein FAM220A (FAM220A) . Q7Z4H9
Protein hinderin (KIAA1328) . Q86T90
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Stabilizer of axonemal microtubules 5 (SAXO5) . Q8NA69
Vinexin (SORBS3) . O60504
Zinc finger CCHC domain-containing protein 7 (ZCCHC7) . Q8N3Z6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid20462760c22 Small molecular drug D0V0KA

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840