Details of the Target

General Information of Target

Target ID LDTP11640
Target Name Very long chain fatty acid elongase 4 (ELOVL4)
Gene Name ELOVL4
Gene ID 6785
Synonyms
Very long chain fatty acid elongase 4; EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL4; ELOVL fatty acid elongase 4; ELOVL FA elongase 4; Elongation of very long chain fatty acids protein 4; Very long chain 3-ketoacyl-CoA synthase 4; Very long chain 3-oxoacyl-CoA synthase 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPP
KAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMP
AGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRK
AKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGL
TRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPEN
LKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSG
RPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSD
DA
Target Bioclass
Enzyme
Family
ELO family, ELOVL4 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {|HAMAP-Rule:MF_03204}.
Uniprot ID
Q9GZR5
Ensemble ID
ENST00000369816.5
HGNC ID
HGNC:14415
ChEMBL ID
CHEMBL5169195

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C163(1.52)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C163(1.52)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C163(0.96)  LDD1509  [1]
 LDCM0277  AC18 HEK-293T C163(1.04)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C163(0.85)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C163(0.82)  LDD1518  [1]
 LDCM0284  AC24 HEK-293T C163(1.32)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C163(1.22)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C163(1.09)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C163(0.90)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C163(1.33)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C163(1.28)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C163(1.04)  LDD1535  [1]
 LDCM0302  AC40 HEK-293T C163(1.20)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C163(1.23)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C163(1.03)  LDD1544  [1]
 LDCM0310  AC48 HEK-293T C163(1.02)  LDD1549  [1]
 LDCM0313  AC50 HEK-293T C163(1.24)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C163(1.08)  LDD1553  [1]
 LDCM0319  AC56 HEK-293T C163(1.22)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C163(0.99)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C163(1.03)  LDD1561  [1]
 LDCM0328  AC64 HEK-293T C163(1.07)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C163(1.10)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C163(1.12)  LDD1514  [1]
 LDCM0369  CL100 HEK-293T C163(1.60)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C163(1.20)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C163(1.99)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C163(1.32)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C163(1.78)  LDD1590  [1]
 LDCM0390  CL12 HEK-293T C163(0.48)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C163(1.62)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C163(1.31)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C163(1.13)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C163(1.39)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C163(0.83)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C163(0.81)  LDD1610  [1]
 LDCM0412  CL24 HEK-293T C163(0.48)  LDD1616  [1]
 LDCM0416  CL28 HEK-293T C163(2.58)  LDD1620  [1]
 LDCM0419  CL30 HEK-293T C163(0.65)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C163(0.84)  LDD1624  [1]
 LDCM0425  CL36 HEK-293T C163(0.53)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C163(1.00)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C163(1.02)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C163(0.65)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C163(0.74)  LDD1637  [1]
 LDCM0438  CL48 HEK-293T C163(0.36)  LDD1642  [1]
 LDCM0443  CL52 HEK-293T C163(1.27)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C163(1.51)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C163(0.63)  LDD1649  [1]
 LDCM0451  CL6 HEK-293T C163(0.63)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C163(0.66)  LDD1655  [1]
 LDCM0456  CL64 HEK-293T C163(0.98)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C163(1.54)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C163(0.75)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C163(0.66)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C163(0.57)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C163(1.15)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C163(0.76)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C163(0.74)  LDD1675  [1]
 LDCM0478  CL84 HEK-293T C163(0.53)  LDD1681  [1]
 LDCM0482  CL88 HEK-293T C163(0.87)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C163(1.83)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C163(0.88)  LDD1689  [1]
 LDCM0491  CL96 HEK-293T C163(0.73)  LDD1694  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Palmitoyltransferase ZDHHC21 (ZDHHC21) DHHC palmitoyltransferase family Q8IVQ6
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Matrix metalloproteinase-14 (MMP14) Peptidase M10A family P50281
Squalene synthase (FDFT1) Phytoene/squalene synthase family P37268
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
Ras-related protein Rab-18 (RAB18) Rab family Q9NP72
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Transporter and channel
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Synapse differentiation-inducing gene protein 1 (SYNDIG1) CD225/Dispanin family Q9H7V2
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Glycophorin-A (GYPA) Glycophorin A family P02724
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Cardiac phospholamban (PLN) Phospholamban family P26678
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-3 (STX3) Syntaxin family Q13277
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Transmembrane protein 199 (TMEM199) . Q8N511
Transmembrane protein 203 (TMEM203) . Q969S6
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Adhesion G protein-coupled receptor E2 (ADGRE2) G-protein coupled receptor 2 family Q9UHX3
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Cytokine and receptor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
CD70 antigen (CD70) Tumor necrosis factor family P32970
Other
Click To Hide/Show 38 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Protein FAM3C (FAM3C) FAM3 family Q92520
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
MAL-like protein (MALL) MAL family Q13021
Plasmolipin (PLLP) MAL family Q9Y342
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 2 (ORMDL2) ORM family Q53FV1
ORM1-like protein 3 (ORMDL3) ORM family Q8N138
Claudin domain-containing protein 2 (CLDND2) PMP-22/EMP/MP20 family Q8NHS1
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Small EDRK-rich factor 1 (SERF1A; SERF1B) SERF family O75920
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Serotransferrin (TF) Transferrin family P02787
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Protein YIF1A (YIF1A) YIF1 family O95070
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Bcl-2-interacting killer (BIK) . Q13323
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6
Lymphocyte antigen 6D (LY6D) . Q14210
Protein SNORC (SNORC) . Q6UX34
Transmembrane protein 222 (TMEM222) . Q9H0R3
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 42 (TMEM42) . Q69YG0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Omega-3-carboxylic Acids . DB09568

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402