Details of the Target

General Information of Target

Target ID LDTP11427
Target Name Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)
Gene Name PACSIN1
Gene ID 29993
Synonyms
KIAA1379; Protein kinase C and casein kinase substrate in neurons protein 1; Syndapin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAEWELGAEAGGSLLLCAALLAAGCALGLRLGRGQGAADRGALIWLCYDALVHFALEGP
FVYLSLVGNVANSDGLIASLWKEYGKADARWVYFDPTIVSVEILTVALDGSLALFLIYAI
VKEKYYRHFLQITLCVCELYGCWMTFLPEWLTRSPNLNTSNWLYCWLYLFFFNGVWVLIP
GLLLWQSWLELKKMHQKETSSVKKFQ
Target Bioclass
Other
Family
PACSIN family
Subcellular location
Cytoplasm
Function
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Uniprot ID
Q9BY11
Ensemble ID
ENST00000244458.7
HGNC ID
HGNC:8570

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C39(1.03); C45(1.03)  LDD0532  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C39(1.03); C45(1.03)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C39(0.91); C45(0.91)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C39(0.88); C45(0.88)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C39(1.07); C45(0.83)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C39(1.26); C45(0.88)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C39(1.09); C45(1.10)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C39(1.00); C45(1.04)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C39(1.17); C45(0.92)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C39(1.50); C45(0.88)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C39(0.97); C45(0.97)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C39(1.12); C45(0.88)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C39(1.21); C45(0.98)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C39(1.33); C45(1.21)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C39(1.35); C45(0.92)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C39(1.19); C45(1.11)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C39(1.30); C45(1.09)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C39(1.43); C45(1.04)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C39(1.45); C45(1.12)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C39(0.96); C45(0.96)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C39(0.99); C45(0.99)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C39(0.58); C45(0.58)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C39(0.75); C45(0.75)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C39(0.54); C45(0.54)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C39(0.48); C45(0.48)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C39(0.77); C45(0.77)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C39(0.55); C45(0.55)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C39(1.31); C45(1.31)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C39(0.67); C45(0.67)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C39(1.15); C45(1.15)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C39(0.55); C45(0.55)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C39(0.80); C45(0.80)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C39(0.60); C45(0.60)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C39(0.63); C45(0.63)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C39(0.91); C45(0.91)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C39(0.81); C45(0.81)  LDD2161  [1]
 LDCM0323  AC6 HCT 116 C39(0.91); C45(0.91)  LDD0640  [1]
 LDCM0332  AC68 HCT 116 C39(0.82); C45(0.82)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C39(0.89); C45(0.89)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C39(1.08); C45(1.08)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C39(0.65); C45(0.65)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C39(0.90); C45(0.90)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C39(0.99); C45(0.99)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C39(1.16); C45(1.16)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C39(0.80); C45(0.80)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C39(1.17); C45(1.17)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C39(0.98); C45(0.98)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C39(0.96); C45(0.96)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C39(1.24); C45(1.24)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C39(0.88); C45(0.88)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C39(1.26); C45(1.26)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C39(1.02); C45(1.02)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C39(0.92); C45(0.92)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C39(0.99); C45(0.99)  LDD0665  [1]
 LDCM0248  AKOS034007472 HCT 116 C39(1.15); C45(1.15)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C39(0.91); C45(0.91)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C39(1.31); C45(1.31)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C39(0.72); C45(0.72)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C39(0.85); C45(0.85)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C39(1.08); C45(1.08)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C39(0.90); C45(0.90)  LDD0690  [1]
 LDCM0022  KB02 A2780 C164(1.61)  LDD2254  [3]
 LDCM0023  KB03 A2780 C164(1.92)  LDD2671  [3]
 LDCM0024  KB05 OAW-42 C164(1.64)  LDD3369  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840