Details of the Target

General Information of Target

Target ID LDTP11358
Target Name TM2 domain-containing protein 1 (TM2D1)
Gene Name TM2D1
Gene ID 83941
Synonyms
BBP; TM2 domain-containing protein 1; Amyloid-beta-binding protein; hBBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPP
APPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVH
FLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASL
CLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQ
VTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFI
DRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQV
NIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGT
KGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT
Target Bioclass
Other
Family
TM2 family
Subcellular location
Membrane
Function May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
Uniprot ID
Q9BX74
Ensemble ID
ENST00000371180.7
HGNC ID
HGNC:24142

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C58(0.93)  LDD1509  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
W1
 Probe Info  		D60(0.00); Y56(0.00)  LDD0236  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C58(0.93)  LDD1509  [1]
 LDCM0278  AC19 HEK-293T C58(1.23)  LDD1517  [1]
 LDCM0281  AC21 HEK-293T C58(0.96)  LDD1520  [1]
 LDCM0284  AC24 HEK-293T C58(0.85)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C58(0.93)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C58(1.06)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C58(0.99)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C58(0.82)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C58(0.89)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C58(0.87)  LDD1537  [1]
 LDCM0302  AC40 HEK-293T C58(0.93)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C58(0.81)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C58(0.99)  LDD1546  [1]
 LDCM0310  AC48 HEK-293T C58(0.90)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C58(0.93)  LDD1551  [1]
 LDCM0314  AC51 HEK-293T C58(0.90)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C58(0.87)  LDD1555  [1]
 LDCM0319  AC56 HEK-293T C58(0.85)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C58(0.92)  LDD1561  [1]
 LDCM0325  AC61 HEK-293T C58(0.93)  LDD1564  [1]
 LDCM0328  AC64 HEK-293T C58(0.84)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C58(1.00)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C58(0.92)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C58(1.05)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C58(1.01)  LDD1571  [1]
 LDCM0369  CL100 HEK-293T C58(1.02)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C58(0.91)  LDD1574  [1]
 LDCM0373  CL104 HEK-293T C58(1.05)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C58(1.06)  LDD1578  [1]
 LDCM0377  CL108 HEK-293T C58(1.28)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C58(0.86)  LDD1582  [1]
 LDCM0382  CL112 HEK-293T C58(1.01)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C58(0.78)  LDD1587  [1]
 LDCM0386  CL116 HEK-293T C58(1.01)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C58(1.08)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C58(0.91)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C58(0.95)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C58(1.09)  LDD1596  [1]
 LDCM0395  CL124 HEK-293T C58(1.00)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C58(1.01)  LDD1600  [1]
 LDCM0399  CL128 HEK-293T C58(0.97)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C58(1.12)  LDD1604  [1]
 LDCM0403  CL16 HEK-293T C58(0.99)  LDD1607  [1]
 LDCM0406  CL19 HEK-293T C58(0.91)  LDD1610  [1]
 LDCM0409  CL21 HEK-293T C58(1.11)  LDD1613  [1]
 LDCM0412  CL24 HEK-293T C58(1.34)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C58(1.08)  LDD1617  [1]
 LDCM0416  CL28 HEK-293T C58(1.07)  LDD1620  [1]
 LDCM0420  CL31 HEK-293T C58(0.82)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C58(1.14)  LDD1626  [1]
 LDCM0425  CL36 HEK-293T C58(0.86)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C58(0.99)  LDD1630  [1]
 LDCM0429  CL4 HEK-293T C58(0.99)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C58(1.15)  LDD1634  [1]
 LDCM0433  CL43 HEK-293T C58(0.76)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C58(1.00)  LDD1639  [1]
 LDCM0438  CL48 HEK-293T C58(0.92)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C58(1.06)  LDD1643  [1]
 LDCM0443  CL52 HEK-293T C58(1.16)  LDD1646  [1]
 LDCM0446  CL55 HEK-293T C58(0.85)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C58(0.91)  LDD1651  [1]
 LDCM0452  CL60 HEK-293T C58(0.98)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C58(0.96)  LDD1656  [1]
 LDCM0456  CL64 HEK-293T C58(1.09)  LDD1659  [1]
 LDCM0459  CL67 HEK-293T C58(0.86)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C58(0.96)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C58(0.93)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C58(0.94)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C58(1.04)  LDD1669  [1]
 LDCM0469  CL76 HEK-293T C58(1.26)  LDD1672  [1]
 LDCM0472  CL79 HEK-293T C58(0.93)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C58(0.83)  LDD1678  [1]
 LDCM0478  CL84 HEK-293T C58(0.97)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C58(1.17)  LDD1682  [1]
 LDCM0482  CL88 HEK-293T C58(1.08)  LDD1685  [1]
 LDCM0484  CL9 HEK-293T C58(1.06)  LDD1687  [1]
 LDCM0486  CL91 HEK-293T C58(0.99)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C58(0.79)  LDD1691  [1]
 LDCM0491  CL96 HEK-293T C58(1.36)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C58(1.18)  LDD1695  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.