Details of the Target

General Information of Target

Target ID LDTP11067
Target Name Histone H4 transcription factor (HINFP)
Gene Name HINFP
Gene ID 25988
Synonyms
MIZF; ZNF743; Histone H4 transcription factor; Histone nuclear factor P; HiNF-P; MBD2-interacting zinc finger protein; Methyl-CpG-binding protein 2-interacting zinc finger protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL
FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFC
KYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD
SVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLV
DTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFV
RDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
Uniprot ID
Q9BQA5
Ensemble ID
ENST00000350777.7
HGNC ID
HGNC:17850

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L419P .
HCT15 SNV: p.G499E .
JURKAT SNV: p.E510Ter .
KMCH1 SNV: p.T305S .
LU65 SNV: p.W133L .
MOLT4 SNV: p.R334H .
NCIH1793 SNV: p.G48V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C178(1.02)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C178(1.02)  LDD1508  [1]
 LDCM0270  AC15 HEK-293T C178(0.98)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C178(0.96)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C178(1.04)  LDD1518  [1]
 LDCM0283  AC23 HEK-293T C178(1.07)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C178(1.09)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C178(0.94)  LDD1525  [1]
 LDCM0292  AC31 HEK-293T C178(0.92)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C178(1.07)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C178(1.04)  LDD1534  [1]
 LDCM0300  AC39 HEK-293T C178(1.22)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C178(1.03)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C178(0.99)  LDD1543  [1]
 LDCM0309  AC47 HEK-293T C178(0.97)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C178(0.92)  LDD1549  [1]
 LDCM0313  AC50 HEK-293T C178(1.00)  LDD1552  [1]
 LDCM0318  AC55 HEK-293T C178(1.05)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C178(1.05)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C178(1.08)  LDD1560  [1]
 LDCM0327  AC63 HEK-293T C178(1.16)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C178(1.04)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C178(0.93)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C178(1.03)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C178(1.00)  LDD1514  [1]
 LDCM0379  CL11 HEK-293T C178(0.98)  LDD1583  [1]
 LDCM0390  CL12 HEK-293T C178(1.02)  LDD1594  [1]
 LDCM0405  CL18 HEK-293T C178(0.98)  LDD1609  [1]
 LDCM0411  CL23 HEK-293T C178(1.18)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C178(1.00)  LDD1616  [1]
 LDCM0419  CL30 HEK-293T C178(1.15)  LDD1623  [1]
 LDCM0424  CL35 HEK-293T C178(0.99)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C178(0.95)  LDD1629  [1]
 LDCM0432  CL42 HEK-293T C178(1.07)  LDD1636  [1]
 LDCM0437  CL47 HEK-293T C178(0.99)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C178(0.94)  LDD1642  [1]
 LDCM0445  CL54 HEK-293T C178(0.96)  LDD1648  [1]
 LDCM0450  CL59 HEK-293T C178(1.04)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C178(0.87)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C178(0.98)  LDD1655  [1]
 LDCM0458  CL66 HEK-293T C178(1.00)  LDD1661  [1]
 LDCM0464  CL71 HEK-293T C178(1.01)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C178(1.14)  LDD1668  [1]
 LDCM0471  CL78 HEK-293T C178(1.09)  LDD1674  [1]
 LDCM0477  CL83 HEK-293T C178(0.96)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C178(0.96)  LDD1681  [1]
 LDCM0485  CL90 HEK-293T C178(0.83)  LDD1688  [1]
 LDCM0490  CL95 HEK-293T C178(0.83)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C178(0.86)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402