Details of the Target

General Information of Target

Target ID LDTP11061
Target Name Structure-specific endonuclease subunit SLX1 (SLX1A; SLX1B)
Gene Name SLX1A; SLX1B
Gene ID 548593
Synonyms
GIYD1; SLX1; GIYD2; SLX1; Structure-specific endonuclease subunit SLX1; EC 3.1.-.-; GIY-YIG domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRALRRLRGEQRGQEPLGPGALHFDLRDDDDAEEEGPKRELGVRRPGGAGKEGVRVNN
RFELINIDDLEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTETVPSEQSH
ASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIEDSTGLNRPGPAPLSSRKHVLYV
EHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLE
SKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQE
DQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPENRSFYLALYKQMSFLEKRGCP
RTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAF
SVPLAYFLLSQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSH
RFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEAC
ENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPER
LSPISHGNTIALFFRSLLPNYTMEGERPEEGVAGGLNRNQGLNRLMLAVRDMMANFHLND
LEAPHEDDAEGEGEWD
Target Bioclass
Enzyme
Family
SLX1 family
Subcellular location
Nucleus
Function
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {|HAMAP-Rule:MF_03100}.
Uniprot ID
Q9BQ83
Ensemble ID
ENST00000251303.11
HGNC ID
HGNC:20922

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C237(0.91)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C251(0.93)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C237(1.02)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C251(0.88)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C251(1.10); C237(0.85)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C251(0.95)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C237(0.93)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C251(0.88)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C251(1.14); C237(1.03)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C251(1.02)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C237(0.96)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C251(1.06)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C251(0.79)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C251(1.04); C237(0.96)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C251(1.03)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C237(0.83)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C251(0.96)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C251(1.27); C237(0.91)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C237(0.84)  LDD1540  [1]
 LDCM0305  AC43 HEK-293T C251(1.05)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C237(1.01)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C251(0.89)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C251(1.20); C237(1.02)  LDD1548  [1]
 LDCM0314  AC51 HEK-293T C251(1.01)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C237(1.00)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C251(0.92)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C251(1.18); C237(0.97)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C251(0.95)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C251(0.95)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C237(1.00)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C251(0.86)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C251(1.01); C237(1.08)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C251(1.10); C237(1.04)  LDD1568  [1]
 LDCM0368  CL10 HEK-293T C251(0.79)  LDD1572  [1]
 LDCM0371  CL102 HEK-293T C251(0.86)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C251(0.89)  LDD1579  [1]
 LDCM0379  CL11 HEK-293T C251(0.93); C237(0.76)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C251(0.99)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C251(0.95)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C251(0.97)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C251(0.81)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C251(0.95)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C251(0.91)  LDD1605  [1]
 LDCM0406  CL19 HEK-293T C251(1.09)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C251(0.83)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C237(0.72)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C251(0.97)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C251(1.19); C237(0.64)  LDD1615  [1]
 LDCM0414  CL26 HEK-293T C251(0.96)  LDD1618  [1]
 LDCM0420  CL31 HEK-293T C251(1.19)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C237(0.75)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C251(0.88)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C251(0.97); C237(0.68)  LDD1628  [1]
 LDCM0433  CL43 HEK-293T C251(0.94)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C237(0.74)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C251(0.88)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C251(0.93); C237(0.72)  LDD1641  [1]
 LDCM0441  CL50 HEK-293T C251(0.83)  LDD1645  [1]
 LDCM0446  CL55 HEK-293T C251(1.14)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C237(0.72)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C251(0.78)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C251(0.98); C237(0.88)  LDD1653  [1]
 LDCM0454  CL62 HEK-293T C251(0.95)  LDD1657  [1]
 LDCM0459  CL67 HEK-293T C251(1.14)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C237(0.80)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C251(0.91)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C251(0.86)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C251(1.08); C237(0.67)  LDD1667  [1]
 LDCM0467  CL74 HEK-293T C251(0.99)  LDD1670  [1]
 LDCM0472  CL79 HEK-293T C251(1.12)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C237(0.55)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C237(0.83)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C251(0.91)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C251(1.12); C237(0.72)  LDD1680  [1]
 LDCM0480  CL86 HEK-293T C251(1.00)  LDD1683  [1]
 LDCM0486  CL91 HEK-293T C251(0.99)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C237(0.85)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C251(0.68)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C251(1.06); C237(0.62)  LDD1693  [1]
 LDCM0493  CL98 HEK-293T C251(0.83)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C251(0.86)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C237(0.91)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C237(0.98)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C237(1.06)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402