Details of the Target

General Information of Target

Target ID LDTP11048
Target Name Testican-3 (SPOCK3)
Gene Name SPOCK3
Gene ID 50859
Synonyms
TICN3; Testican-3; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGN
LIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYSTQQA
PNKAVQNDSNPSASQPTTGPSAASPASENQNGNGLSAPPGPGGGPHPPHTPSHPPSTRIT
RSQPNHTPAGPPGPSSNPVSNGKETRRSSKR
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
Uniprot ID
Q9BQ16
Ensemble ID
ENST00000357154.7
HGNC ID
HGNC:13565

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.N224K .
EGI1 SNV: p.N299T .
HCT15 SNV: p.A6V; p.C9R .
IGR1 SNV: p.M118I .
IGROV1 SNV: p.A106T .
LU65 Substitution: p.G420L .
MFE319 SNV: p.G354E .
NCIH358 SNV: p.D427N .
NCIH661 SNV: p.P146H .
PF382 SNV: p.E394V .
SNGM SNV: p.R68C .
SW403 SNV: p.N37S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(1.05)  LDD1507  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C139(1.05)  LDD1507  [1]
 LDCM0237  AC12 HEK-293T C201(1.13)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C139(0.97)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C139(1.17)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C139(0.98)  LDD1515  [1]
 LDCM0280  AC20 HEK-293T C201(1.11)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C139(0.88); C201(0.84)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C139(0.95)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C139(1.05)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C139(1.15)  LDD1524  [1]
 LDCM0288  AC28 HEK-293T C201(1.00)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C139(0.96); C201(1.01)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C139(0.99)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C139(1.09)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C139(1.10)  LDD1533  [1]
 LDCM0297  AC36 HEK-293T C201(0.96)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C139(0.94); C201(0.90)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C139(0.90)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C139(0.97)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C201(1.02)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C139(0.98)  LDD1542  [1]
 LDCM0306  AC44 HEK-293T C201(1.11)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C139(1.07); C201(0.95)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C139(1.09)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C139(1.08)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C139(1.10)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C139(0.98); C201(0.73)  LDD1551  [1]
 LDCM0315  AC52 HEK-293T C201(1.15)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C139(0.95); C201(1.02)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C139(0.94)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C139(0.95)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C139(1.03)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C139(0.99)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C201(1.06)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C139(0.91); C201(0.94)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C139(1.04)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C139(1.01)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C139(1.04)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C139(1.11); C201(0.87)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C139(1.02)  LDD1570  [1]
 LDCM0368  CL10 HEK-293T C139(1.46)  LDD1572  [1]
 LDCM0372  CL103 HEK-293T C139(1.01)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C139(0.95)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C139(1.18)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C139(0.87)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C139(0.95)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C139(0.98)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C139(0.97)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C139(0.92)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C139(0.98)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C139(0.94)  LDD1608  [1]
 LDCM0408  CL20 HEK-293T C201(1.05)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C139(0.91); C201(1.32)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C139(0.99)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C139(1.19)  LDD1615  [1]
 LDCM0415  CL27 HEK-293T C139(0.98)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C139(0.99)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C139(0.92)  LDD1622  [1]
 LDCM0421  CL32 HEK-293T C201(1.12)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C139(1.03); C201(1.75)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C139(0.94)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C139(1.10)  LDD1628  [1]
 LDCM0428  CL39 HEK-293T C139(0.91)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C139(1.08)  LDD1635  [1]
 LDCM0434  CL44 HEK-293T C201(1.04)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C139(1.19); C201(1.28)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C139(0.99)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C139(1.07)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C139(1.03)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C139(1.05)  LDD1647  [1]
 LDCM0447  CL56 HEK-293T C201(1.10)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C139(1.17); C201(1.50)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C139(1.11)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C139(1.30)  LDD1653  [1]
 LDCM0455  CL63 HEK-293T C139(1.02)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C139(1.03)  LDD1660  [1]
 LDCM0460  CL68 HEK-293T C201(1.52)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C139(1.15); C201(1.17)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C139(1.09)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C139(1.27)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C139(1.10)  LDD1673  [1]
 LDCM0473  CL8 HEK-293T C201(1.37)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C201(1.15)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C139(0.90); C201(1.12)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C139(1.06)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C139(1.05)  LDD1680  [1]
 LDCM0481  CL87 HEK-293T C139(1.04)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C139(1.06)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C139(1.07); C201(1.11)  LDD1687  [1]
 LDCM0487  CL92 HEK-293T C201(1.33)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C139(1.01); C201(1.18)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C139(1.01)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C139(1.11)  LDD1693  [1]
 LDCM0494  CL99 HEK-293T C139(1.03)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C139(0.86)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C139(1.02)  LDD1671  [1]
 LDCM0022  KB02 A204 C88(1.88)  LDD2252  [3]
 LDCM0023  KB03 A204 C88(2.35)  LDD2669  [3]
 LDCM0024  KB05 G-401 C88(1.97)  LDD3164  [3]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840