Details of the Target

General Information of Target

Target ID LDTP10677
Target Name Methylmalonyl-CoA epimerase, mitochondrial (MCEE)
Gene Name MCEE
Gene ID 84693
Synonyms
Methylmalonyl-CoA epimerase, mitochondrial; EC 5.1.99.1; DL-methylmalonyl-CoA racemase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL
DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY
DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR
PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG
NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT
IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI
GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT
LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD
YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC
IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPST
MPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS
APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS
TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD
ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV
LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD
RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA
FPKHYRPPEGTYGKVET
Target Bioclass
Enzyme
Family
Methylmalonyl-CoA epimerase family
Subcellular location
Mitochondrion
Function Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism.
Uniprot ID
Q96PE7
Ensemble ID
ENST00000244217.6
HGNC ID
HGNC:16732

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C166(0.91)  LDD1509  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C166(0.91)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C166(1.38)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C166(1.10)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C166(0.67)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C166(0.74)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C166(1.08)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C166(1.02)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C166(1.17)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C166(1.08)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C166(1.55)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C166(1.34)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C166(0.94)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C166(1.06)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C166(1.10)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C166(1.09)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C166(1.62)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C166(1.00)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C166(1.45)  LDD1540  [1]
 LDCM0305  AC43 HEK-293T C166(1.63)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C166(1.47)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C166(1.11)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C166(0.88)  LDD1548  [1]
 LDCM0314  AC51 HEK-293T C166(0.91)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C166(2.13)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C166(1.08)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C166(1.15)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C166(1.17)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C166(1.10)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C166(1.18)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C166(1.34)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C166(0.80)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C166(1.36)  LDD1568  [1]
 LDCM0367  CL1 HEK-293T C166(0.74)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C166(0.99)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C166(0.67)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C166(1.06)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C166(0.75)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C166(0.94)  LDD1583  [1]
 LDCM0383  CL113 HEK-293T C166(0.73)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C166(1.00)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C166(0.85)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C166(1.25)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C166(0.80)  LDD1604  [1]
 LDCM0406  CL19 HEK-293T C166(1.40)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C166(1.41)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C166(1.27)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C166(1.03)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C166(0.68)  LDD1617  [1]
 LDCM0420  CL31 HEK-293T C166(0.67)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C166(1.18)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C166(1.03)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C166(0.90)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C166(0.80)  LDD1630  [1]
 LDCM0433  CL43 HEK-293T C166(0.87)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C166(1.39)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C166(1.05)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C166(1.05)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C166(0.69)  LDD1643  [1]
 LDCM0446  CL55 HEK-293T C166(1.10)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C166(1.53)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C166(1.03)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C166(1.02)  LDD1653  [1]
 LDCM0453  CL61 HEK-293T C166(1.17)  LDD1656  [1]
 LDCM0459  CL67 HEK-293T C166(0.98)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C166(1.20)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C166(1.09)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C166(1.60)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C166(1.15)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C166(0.79)  LDD1669  [1]
 LDCM0472  CL79 HEK-293T C166(0.88)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C166(0.92)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C166(1.44)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C166(1.09)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C166(0.64)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C166(0.95)  LDD1682  [1]
 LDCM0486  CL91 HEK-293T C166(1.02)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C166(1.23)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C166(0.95)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C166(0.61)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C166(0.63)  LDD1695  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377