Details of the Target
General Information of Target
Target ID | LDTP10599 | |||||
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Target Name | YTH domain-containing protein 1 (YTHDC1) | |||||
Gene Name | YTHDC1 | |||||
Gene ID | 91746 | |||||
Synonyms |
KIAA1966; YT521; YTH domain-containing protein 1; Splicing factor YT521; YT521-B |
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3D Structure | ||||||
Sequence |
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV MKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDR IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS PQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLG SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK |
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Target Bioclass |
Other
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Subcellular location |
Nucleus
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Function |
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May also regulate alternative splice site selection. Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs. Also recognizes and binds m6A on other RNA molecules. Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist. Also recognizes and binds m6A-containing single-stranded DNA. Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Target Site Mutations in Different Cell Lines
Cell line | Mutation details | Probe for labeling this protein in this cell | |||
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AN3CA | SNV: p.A459T | DBIA Probe Info | |||
COLO792 | SNV: p.R341Ter | . | |||
DU145 | Deletion: p.K43RfsTer32 | . | |||
G361 | Substitution: p.P567L | . | |||
GB2 | SNV: p.K408E | . | |||
HCC1954 | Deletion: p.E247_E249del | . | |||
HUH1 | SNV: p.N363Y | . | |||
JVM3 | Deletion: p.L491VfsTer5 | . | |||
LN229 | SNV: p.E234K | . | |||
MCC26 | Substitution: p.S122F | . | |||
OV90 | SNV: p.R162C | . | |||
PEO1 | SNV: p.E240Ter | . | |||
TE4 | SNV: p.D272V | . | |||
TOV21G | SNV: p.G11V | . |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
STPyne Probe Info |
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K347(6.25); K349(6.25); K361(0.60); K374(5.88) | LDD0277 | [1] | |
DBIA Probe Info |
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C449(6.52) | LDD3409 | [2] | |
BTD Probe Info |
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C134(2.46) | LDD2116 | [3] | |
IA-alkyne Probe Info |
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N.A. | LDD0162 | [4] | |
NAIA_5 Probe Info |
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C449(0.00); C713(0.00) | LDD2224 | [5] | |
IPM Probe Info |
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C713(0.00); C134(0.00) | LDD0147 | [6] | |
SF Probe Info |
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Y95(0.00); Y100(0.00) | LDD0028 | [7] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [8] | |
Acrolein Probe Info |
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N.A. | LDD0217 | [9] | |
Crotonaldehyde Probe Info |
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N.A. | LDD0219 | [9] | |
Methacrolein Probe Info |
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N.A. | LDD0218 | [9] |
PAL-AfBPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
FFF probe2 Probe Info |
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20.00 | LDD0463 | [10] | |
FFF probe3 Probe Info |
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6.40 | LDD0464 | [10] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0215 | AC10 | PaTu 8988t | C484(0.68); C489(0.68) | LDD1094 | [11] |
LDCM0226 | AC11 | PaTu 8988t | C484(0.68); C489(0.68) | LDD1105 | [11] |
LDCM0237 | AC12 | PaTu 8988t | C484(0.84); C489(0.84) | LDD1116 | [11] |
LDCM0259 | AC14 | PaTu 8988t | C484(0.91); C489(0.91) | LDD1138 | [11] |
LDCM0270 | AC15 | PaTu 8988t | C484(0.65); C489(0.65) | LDD1149 | [11] |
LDCM0277 | AC18 | HEK-293T | C489(1.12) | LDD1516 | [12] |
LDCM0278 | AC19 | HEK-293T | C484(1.03) | LDD1517 | [12] |
LDCM0279 | AC2 | HEK-293T | C489(1.01) | LDD1518 | [12] |
LDCM0280 | AC20 | HEK-293T | C484(0.99) | LDD1519 | [12] |
LDCM0282 | AC22 | HEK-293T | C484(1.05) | LDD1521 | [12] |
LDCM0285 | AC25 | PaTu 8988t | C484(0.82); C489(0.82) | LDD1164 | [11] |
LDCM0286 | AC26 | PaTu 8988t | C484(1.23); C489(1.23) | LDD1165 | [11] |
LDCM0287 | AC27 | PaTu 8988t | C484(0.89); C489(0.89) | LDD1166 | [11] |
LDCM0288 | AC28 | PaTu 8988t | C484(0.84); C489(0.84) | LDD1167 | [11] |
LDCM0289 | AC29 | PaTu 8988t | C484(1.00); C489(1.00) | LDD1168 | [11] |
LDCM0290 | AC3 | HEK-293T | C484(0.96) | LDD1529 | [12] |
LDCM0291 | AC30 | PaTu 8988t | C484(0.89); C489(0.89) | LDD1170 | [11] |
LDCM0292 | AC31 | PaTu 8988t | C484(1.03); C489(1.03) | LDD1171 | [11] |
LDCM0293 | AC32 | PaTu 8988t | C484(1.21); C489(1.21) | LDD1172 | [11] |
LDCM0294 | AC33 | PaTu 8988t | C484(0.94); C489(0.94) | LDD1173 | [11] |
LDCM0295 | AC34 | PaTu 8988t | C484(0.98); C489(0.98) | LDD1174 | [11] |
LDCM0296 | AC35 | PaTu 8988t | C484(0.89); C489(0.89) | LDD1175 | [11] |
LDCM0297 | AC36 | PaTu 8988t | C484(0.80); C489(0.80) | LDD1176 | [11] |
LDCM0298 | AC37 | PaTu 8988t | C484(0.76); C489(0.76) | LDD1177 | [11] |
LDCM0299 | AC38 | PaTu 8988t | C484(0.94); C489(0.94) | LDD1178 | [11] |
LDCM0300 | AC39 | PaTu 8988t | C484(1.00); C489(1.00) | LDD1179 | [11] |
LDCM0301 | AC4 | HEK-293T | C484(0.91) | LDD1540 | [12] |
LDCM0302 | AC40 | PaTu 8988t | C484(0.96); C489(0.96) | LDD1181 | [11] |
LDCM0303 | AC41 | PaTu 8988t | C484(1.01); C489(1.01) | LDD1182 | [11] |
LDCM0304 | AC42 | PaTu 8988t | C484(1.03); C489(1.03) | LDD1183 | [11] |
LDCM0305 | AC43 | PaTu 8988t | C484(0.81); C489(0.81) | LDD1184 | [11] |
LDCM0306 | AC44 | PaTu 8988t | C484(0.96); C489(0.96) | LDD1185 | [11] |
LDCM0307 | AC45 | PaTu 8988t | C484(1.00); C489(1.00) | LDD1186 | [11] |
LDCM0308 | AC46 | PaTu 8988t | C484(1.20); C489(1.20) | LDD1187 | [11] |
LDCM0309 | AC47 | PaTu 8988t | C484(1.08); C489(1.08) | LDD1188 | [11] |
LDCM0310 | AC48 | PaTu 8988t | C484(1.01); C489(1.01) | LDD1189 | [11] |
LDCM0311 | AC49 | PaTu 8988t | C484(1.29); C489(1.29) | LDD1190 | [11] |
LDCM0313 | AC50 | PaTu 8988t | C484(1.30); C489(1.30) | LDD1192 | [11] |
LDCM0314 | AC51 | PaTu 8988t | C484(1.43); C489(1.43) | LDD1193 | [11] |
LDCM0315 | AC52 | PaTu 8988t | C484(1.30); C489(1.30) | LDD1194 | [11] |
LDCM0316 | AC53 | PaTu 8988t | C484(1.36); C489(1.36) | LDD1195 | [11] |
LDCM0317 | AC54 | PaTu 8988t | C484(1.40); C489(1.40) | LDD1196 | [11] |
LDCM0318 | AC55 | PaTu 8988t | C484(1.17); C489(1.17) | LDD1197 | [11] |
LDCM0319 | AC56 | PaTu 8988t | C484(1.69); C489(1.69) | LDD1198 | [11] |
LDCM0321 | AC58 | HEK-293T | C489(1.03) | LDD1560 | [12] |
LDCM0322 | AC59 | HEK-293T | C484(0.92) | LDD1561 | [12] |
LDCM0323 | AC6 | PaTu 8988t | C484(0.83); C489(0.83) | LDD1202 | [11] |
LDCM0324 | AC60 | HEK-293T | C484(0.93) | LDD1563 | [12] |
LDCM0326 | AC62 | HEK-293T | C484(1.06) | LDD1565 | [12] |
LDCM0334 | AC7 | PaTu 8988t | C484(1.03); C489(1.03) | LDD1213 | [11] |
LDCM0345 | AC8 | PaTu 8988t | C484(0.76); C489(0.76) | LDD1224 | [11] |
LDCM0248 | AKOS034007472 | PaTu 8988t | C484(1.10); C489(1.10) | LDD1127 | [11] |
LDCM0356 | AKOS034007680 | PaTu 8988t | C484(0.76); C489(0.76) | LDD1235 | [11] |
LDCM0275 | AKOS034007705 | PaTu 8988t | C484(0.76); C489(0.76) | LDD1154 | [11] |
LDCM0108 | Chloroacetamide | HeLa | N.A. | LDD0222 | [9] |
LDCM0368 | CL10 | HEK-293T | C484(0.99) | LDD1572 | [12] |
LDCM0370 | CL101 | PaTu 8988t | C484(0.76); C489(0.76) | LDD1249 | [11] |
LDCM0371 | CL102 | PaTu 8988t | C484(0.66); C489(0.66) | LDD1250 | [11] |
LDCM0372 | CL103 | PaTu 8988t | C484(0.95); C489(0.95) | LDD1251 | [11] |
LDCM0373 | CL104 | PaTu 8988t | C484(0.95); C489(0.95) | LDD1252 | [11] |
LDCM0382 | CL112 | PaTu 8988t | C484(0.90); C489(0.90) | LDD1261 | [11] |
LDCM0383 | CL113 | PaTu 8988t | C484(0.86); C489(0.86) | LDD1262 | [11] |
LDCM0384 | CL114 | PaTu 8988t | C484(1.03); C489(1.03) | LDD1263 | [11] |
LDCM0385 | CL115 | PaTu 8988t | C484(1.12); C489(1.12) | LDD1264 | [11] |
LDCM0386 | CL116 | PaTu 8988t | C484(1.05); C489(1.05) | LDD1265 | [11] |
LDCM0387 | CL117 | PaTu 8988t | C484(0.91); C489(0.91) | LDD1266 | [11] |
LDCM0388 | CL118 | PaTu 8988t | C484(1.38); C489(1.38) | LDD1267 | [11] |
LDCM0389 | CL119 | PaTu 8988t | C484(1.02); C489(1.02) | LDD1268 | [11] |
LDCM0391 | CL120 | PaTu 8988t | C484(0.91); C489(0.91) | LDD1270 | [11] |
LDCM0392 | CL121 | PaTu 8988t | C484(1.05); C489(1.05) | LDD1271 | [11] |
LDCM0393 | CL122 | PaTu 8988t | C484(2.36); C489(2.36) | LDD1272 | [11] |
LDCM0394 | CL123 | PaTu 8988t | C484(1.18); C489(1.18) | LDD1273 | [11] |
LDCM0395 | CL124 | PaTu 8988t | C484(1.19); C489(1.19) | LDD1274 | [11] |
LDCM0405 | CL18 | HEK-293T | C489(1.15) | LDD1609 | [12] |
LDCM0406 | CL19 | HEK-293T | C484(1.00) | LDD1610 | [12] |
LDCM0408 | CL20 | HEK-293T | C484(1.02) | LDD1612 | [12] |
LDCM0410 | CL22 | HEK-293T | C484(1.19) | LDD1614 | [12] |
LDCM0419 | CL30 | HEK-293T | C489(1.21) | LDD1623 | [12] |
LDCM0420 | CL31 | HEK-293T | C484(0.82) | LDD1624 | [12] |
LDCM0421 | CL32 | HEK-293T | C484(0.96) | LDD1625 | [12] |
LDCM0423 | CL34 | HEK-293T | C484(1.07) | LDD1627 | [12] |
LDCM0432 | CL42 | HEK-293T | C489(1.10) | LDD1636 | [12] |
LDCM0433 | CL43 | HEK-293T | C484(0.93) | LDD1637 | [12] |
LDCM0434 | CL44 | HEK-293T | C484(1.08) | LDD1638 | [12] |
LDCM0436 | CL46 | HEK-293T | C484(1.09) | LDD1640 | [12] |
LDCM0445 | CL54 | HEK-293T | C489(1.12) | LDD1648 | [12] |
LDCM0446 | CL55 | HEK-293T | C484(1.10) | LDD1649 | [12] |
LDCM0447 | CL56 | HEK-293T | C484(0.96) | LDD1650 | [12] |
LDCM0449 | CL58 | HEK-293T | C484(1.04) | LDD1652 | [12] |
LDCM0451 | CL6 | HEK-293T | C489(1.28) | LDD1654 | [12] |
LDCM0453 | CL61 | PaTu 8988t | C484(1.02); C489(1.02) | LDD1332 | [11] |
LDCM0454 | CL62 | PaTu 8988t | C484(1.06); C489(1.06) | LDD1333 | [11] |
LDCM0455 | CL63 | PaTu 8988t | C484(1.20); C489(1.20) | LDD1334 | [11] |
LDCM0456 | CL64 | PaTu 8988t | C484(0.94); C489(0.94) | LDD1335 | [11] |
LDCM0457 | CL65 | PaTu 8988t | C484(0.82); C489(0.82) | LDD1336 | [11] |
LDCM0458 | CL66 | PaTu 8988t | C484(0.93); C489(0.93) | LDD1337 | [11] |
LDCM0459 | CL67 | PaTu 8988t | C484(1.00); C489(1.00) | LDD1338 | [11] |
LDCM0460 | CL68 | PaTu 8988t | C484(1.11); C489(1.11) | LDD1339 | [11] |
LDCM0461 | CL69 | PaTu 8988t | C484(1.00); C489(1.00) | LDD1340 | [11] |
LDCM0462 | CL7 | HEK-293T | C484(0.98) | LDD1665 | [12] |
LDCM0463 | CL70 | PaTu 8988t | C484(0.95); C489(0.95) | LDD1342 | [11] |
LDCM0464 | CL71 | PaTu 8988t | C484(1.17); C489(1.17) | LDD1343 | [11] |
LDCM0465 | CL72 | PaTu 8988t | C484(1.23); C489(1.23) | LDD1344 | [11] |
LDCM0466 | CL73 | PaTu 8988t | C484(1.14); C489(1.14) | LDD1345 | [11] |
LDCM0467 | CL74 | PaTu 8988t | C484(1.36); C489(1.36) | LDD1346 | [11] |
LDCM0471 | CL78 | HEK-293T | C489(1.02) | LDD1674 | [12] |
LDCM0472 | CL79 | HEK-293T | C484(0.92) | LDD1675 | [12] |
LDCM0473 | CL8 | HEK-293T | C484(1.68) | LDD1676 | [12] |
LDCM0474 | CL80 | HEK-293T | C484(0.90) | LDD1677 | [12] |
LDCM0476 | CL82 | HEK-293T | C484(1.00) | LDD1679 | [12] |
LDCM0485 | CL90 | HEK-293T | C489(0.80) | LDD1688 | [12] |
LDCM0486 | CL91 | HEK-293T | C484(0.86) | LDD1689 | [12] |
LDCM0487 | CL92 | HEK-293T | C484(1.00) | LDD1690 | [12] |
LDCM0489 | CL94 | HEK-293T | C484(1.09) | LDD1692 | [12] |
LDCM0468 | Fragment33 | PaTu 8988t | C484(1.05); C489(1.05) | LDD1347 | [11] |
LDCM0107 | IAA | HeLa | N.A. | LDD0221 | [9] |
LDCM0022 | KB02 | A673 | C449(3.26) | LDD2261 | [2] |
LDCM0023 | KB03 | A673 | C449(10.11) | LDD2678 | [2] |
LDCM0024 | KB05 | RL95-2 | C449(6.52) | LDD3409 | [2] |
LDCM0109 | NEM | HeLa | N.A. | LDD0227 | [9] |
LDCM0523 | Nucleophilic fragment 24b | MDA-MB-231 | C134(2.46) | LDD2116 | [3] |
LDCM0525 | Nucleophilic fragment 25b | MDA-MB-231 | C713(2.01) | LDD2118 | [3] |
LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C713(0.94) | LDD2120 | [3] |
LDCM0529 | Nucleophilic fragment 27b | MDA-MB-231 | C134(15.40) | LDD2122 | [3] |
LDCM0531 | Nucleophilic fragment 28b | MDA-MB-231 | C713(2.48) | LDD2124 | [3] |
LDCM0555 | Nucleophilic fragment 7b | MDA-MB-231 | C134(10.89) | LDD2149 | [3] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transporter and channel
Protein name | Family | Uniprot ID | |||
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RNA-binding protein with serine-rich domain 1 (RNPS1) | Splicing factor SR family | Q15287 |
Transcription factor
Protein name | Family | Uniprot ID | |||
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PHD finger protein 19 (PHF19) | Polycomblike family | Q5T6S3 |
Other
References