Details of the Target

General Information of Target

Target ID LDTP10565
Target Name Zinc finger protein 597 (ZNF597)
Gene Name ZNF597
Gene ID 146434
Synonyms
Zinc finger protein 597
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSHSGEPALLPCGTCDMVFRSSALLATHTQRFCIGHPTQEMTFGAQASVATEPQRAAVV
PQEHQGVPQEPQGLPDQQASRSALKRLTEEVQWLRLSLQEMRPWITEVPRVFAGPWTRSE
ARPQSPMSEAVGSPSERLRALFRTRARRVAEMEAQSRALQLRGEELSRRLQVVACTRGGM
SRLFGLEQEIRELQAEAGRTRGALEVLGARIQELQAEPGNPLSSRREAELYSPVQKANPG
TLAAEIRALREAYIRDGGRDPGVLGQIWQLQVEASALELQRSQTRRGRAGATSGELPVVE
AENRRLEAEILALQMQRGRAPLGPQDLRLLGDASLQPKGRRDPPLLPPPVAPPLPPLPGF
SEPQLPGTMTRNLGLDSHFLLPTSDMLGPAPYDPGAGLVIFYDFLRGLEASWIWVQLRTG
LARDGRDTGRTTALPPALCLPPPPAPGPMGNCAILASRQPVPRLPPSSSVSLVCELQVWQ
GLAWARAPQPKAWVSLGLFDQDQRVLSGRWRLPLRALPLDPSLSLGQLNGIPQAGQAELF
LRLVNARDAAVQTLAEINPASVHEYQYPPPVSSTSSLEASFLTPAVGFADPPPRTEEPLS
GVKDRDEGLGPHHSSDLPPVSF
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q96LX8
Ensemble ID
ENST00000301744.7
HGNC ID
HGNC:26573

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
NAIA_5
 Probe Info  		C273(20.00)  LDD2227  [2]
DBIA
 Probe Info  		C273(1.19)  LDD0078  [3]
HHS-465
 Probe Info  		K210(0.00); K213(0.00); Y212(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C386(1.26)  LDD1523  [5]
 LDCM0293  AC32 HEK-293T C386(0.94)  LDD1532  [5]
 LDCM0302  AC40 HEK-293T C386(1.12)  LDD1541  [5]
 LDCM0310  AC48 HEK-293T C386(0.91)  LDD1549  [5]
 LDCM0319  AC56 HEK-293T C386(1.11)  LDD1558  [5]
 LDCM0328  AC64 HEK-293T C386(1.06)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C386(0.96)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C386(0.95)  LDD1514  [5]
 LDCM0020  ARS-1620 HCC44 C273(1.19)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C273(20.00)  LDD2227  [2]
 LDCM0369  CL100 HEK-293T C386(1.22)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C386(0.96)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C386(1.03)  LDD1581  [5]
 LDCM0382  CL112 HEK-293T C386(1.08)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C386(1.44)  LDD1590  [5]
 LDCM0390  CL12 HEK-293T C386(1.47)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C386(1.17)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C386(1.31)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C386(1.06)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C386(1.29)  LDD1607  [5]
 LDCM0412  CL24 HEK-293T C386(1.17)  LDD1616  [5]
 LDCM0416  CL28 HEK-293T C386(1.24)  LDD1620  [5]
 LDCM0425  CL36 HEK-293T C386(0.94)  LDD1629  [5]
 LDCM0429  CL4 HEK-293T C386(1.06)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C386(1.64)  LDD1634  [5]
 LDCM0438  CL48 HEK-293T C386(0.95)  LDD1642  [5]
 LDCM0443  CL52 HEK-293T C386(1.04)  LDD1646  [5]
 LDCM0452  CL60 HEK-293T C386(1.16)  LDD1655  [5]
 LDCM0456  CL64 HEK-293T C386(1.04)  LDD1659  [5]
 LDCM0465  CL72 HEK-293T C386(1.42)  LDD1668  [5]
 LDCM0469  CL76 HEK-293T C386(1.08)  LDD1672  [5]
 LDCM0478  CL84 HEK-293T C386(1.36)  LDD1681  [5]
 LDCM0482  CL88 HEK-293T C386(1.13)  LDD1685  [5]
 LDCM0491  CL96 HEK-293T C386(1.12)  LDD1694  [5]
 LDCM0022  KB02 HEK-293T C386(0.75)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C386(0.99)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C386(0.84)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Interleukin-1 receptor-associated kinase 4 (IRAK4) TKL Ser/Thr protein kinase family Q9NWZ3
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prelamin-A/C (LMNA) Intermediate filament family P02545
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402