Details of the Target

General Information of Target

Target ID LDTP10563
Target Name Caspase recruitment domain-containing protein 19 (CARD19)
Gene Name CARD19
Gene ID 84270
Synonyms
C9orf89; Caspase recruitment domain-containing protein 19; Bcl10-interacting CARD protein; BinCARD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRKWEAKLKQIEERASHYERKPLSSVYRPRLSKPEEPPSIWRLFHRQAQAFNFVKSCKE
DVHVFALECKVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKP
ANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLIFQLHDVAFK
DNIHVGNFLRKILQPALDLLGSEDDDSAPETTGHGFPHFSEAPARQGFSFNKMFTEKATE
ESWTSNSKKLERLGSAEQSSPDLSFLVVKNNMGEKHLFVDLGVYTRNRNFRLYKSSKIGK
RVALEVTEDNKFFPIQSKDVSDEYQYFLSSLVSNVRFSDTLRILTCEPSQNKQKGVGYFN
SIGTSVETIEGFQCSPYPEVDHFVLSLVNKDGIKGGIRRWNYFFPEELLVYDICKYRWCE
NIGRAHKSNNIMILVDLKNEVWYQKCHDPVCKAENFKSDCFPLPAEVCLLFLFKEEEEFT
TDEADETRSNETQNPHKPSPSRLSTGASADAVWDNGIDDAYFLEATEDAELAEAAENSLL
SYNSEVDEIPDELIIEVLQE
Target Bioclass
Other
Subcellular location
Nucleus; Endoplasmic reticulum membrane
Function Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Uniprot ID
Q96LW7
Ensemble ID
ENST00000375464.7
HGNC ID
HGNC:28148

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.71  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0122  [2]
TH211
 Probe Info  		Y85(11.08)  LDD0260  [3]
DBIA
 Probe Info  		C63(1.60)  LDD3310  [4]
AHL-Pu-1
 Probe Info  		C63(2.79)  LDD0171  [5]
Acrolein
 Probe Info  		N.A.  LDD0227  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
NAIA_5
 Probe Info  		C63(0.00); C7(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C63(2.10)  LDD0371  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C63(2.79)  LDD0171  [5]
 LDCM0632  CL-Sc Hep-G2 C63(0.90)  LDD2227  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C63(1.66)  LDD1702  [11]
 LDCM0572  Fragment10 Ramos C63(0.98)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C63(20.00)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C63(0.75)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C63(0.94)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C63(0.65)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C63(0.82)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C63(0.99)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C63(1.09)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C63(0.77)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C63(0.84)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C63(0.84)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C63(1.01)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C63(0.65)  LDD2201  [12]
 LDCM0468  Fragment33 Ramos C63(0.88)  LDD2202  [12]
 LDCM0596  Fragment38 Ramos C63(0.94)  LDD2203  [12]
 LDCM0614  Fragment56 Ramos C63(1.22)  LDD2205  [12]
 LDCM0571  Fragment9 Ramos C63(0.99)  LDD2188  [12]
 LDCM0022  KB02 769-P C63(1.67)  LDD2246  [4]
 LDCM0023  KB03 MDA-MB-231 C63(2.80)  LDD1701  [11]
 LDCM0024  KB05 COLO792 C63(1.60)  LDD3310  [4]
 LDCM0109  NEM HeLa N.A.  LDD0227  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578