Details of the Target

General Information of Target

Target ID LDTP10293
Target Name UDP-N-acetylglucosamine transferase subunit ALG14 homolog (ALG14)
Gene Name ALG14
Gene ID 199857
Synonyms
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTQSEQAHLSLELQ
RDSHMKQLLLIQERWKRAQREERLKAQQNTDKDAAAHLQTSHKPSAEDAEGQSPLSQKYS
PSTEKCLPEIQGIFDRDPDTLLYLLQQKSEPAEPCIGSKAPKDDKTIIEEQATKIADLKR
HVEFLVAENERLRKENKQLKAEKARLLKGPIEKELDVDADFVETSELWSLPPHAETATAS
STWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMNN
Target Bioclass
Enzyme
Family
ALG14 family
Subcellular location
Endoplasmic reticulum membrane
Function Involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.
Uniprot ID
Q96F25
Ensemble ID
ENST00000370205.6
HGNC ID
HGNC:28287

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C176(0.94)  LDD1507  [1]
AOyne
 Probe Info  		15.00  LDD0443  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C382
 Probe Info  		10.48  LDD2041  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C176(0.94)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C176(0.96)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C176(0.91)  LDD1509  [1]
 LDCM0276  AC17 HEK-293T C176(1.03)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C176(0.96)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C176(0.97)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C176(0.90)  LDD1518  [1]
 LDCM0285  AC25 HEK-293T C176(0.94)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C176(0.86)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C176(0.98)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C176(0.94)  LDD1529  [1]
 LDCM0294  AC33 HEK-293T C176(1.14)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C176(0.96)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C176(1.00)  LDD1535  [1]
 LDCM0303  AC41 HEK-293T C176(1.19)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C176(0.85)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C176(1.06)  LDD1544  [1]
 LDCM0311  AC49 HEK-293T C176(1.15)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C176(0.92)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C176(0.99)  LDD1553  [1]
 LDCM0320  AC57 HEK-293T C176(1.05)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C176(1.02)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C176(0.88)  LDD1561  [1]
 LDCM0356  AKOS034007680 HEK-293T C176(1.12)  LDD1570  [1]
 LDCM0369  CL100 HEK-293T C176(0.84)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C176(1.02)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C176(1.18)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C176(0.94)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C176(0.94)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C176(0.99)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C176(0.89)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C176(0.98)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C176(1.29)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C176(0.85)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C176(0.97)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C176(1.07)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C176(0.86)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C176(0.97)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C176(1.10)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C176(0.88)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C176(1.32)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C176(1.44)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C176(0.79)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C176(1.28)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C176(1.11)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C176(0.97)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C176(1.09)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C176(1.18)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C176(1.10)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C176(1.16)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C176(0.95)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C176(0.95)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C176(1.24)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C176(1.07)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C176(1.00)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C176(0.86)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C176(1.17)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C176(1.28)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C176(0.95)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C176(1.03)  LDD1624  [1]
 LDCM0428  CL39 HEK-293T C176(1.31)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C176(0.96)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C176(0.88)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C176(1.11)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C176(1.09)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C176(1.07)  LDD1637  [1]
 LDCM0440  CL5 HEK-293T C176(1.33)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C176(0.95)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C176(0.89)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C176(1.18)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C176(1.47)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C176(1.11)  LDD1649  [1]
 LDCM0451  CL6 HEK-293T C176(0.76)  LDD1654  [1]
 LDCM0454  CL62 HEK-293T C176(1.12)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C176(1.14)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C176(0.86)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C176(1.25)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C176(0.94)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C176(1.03)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C176(0.95)  LDD1665  [1]
 LDCM0467  CL74 HEK-293T C176(1.00)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C176(0.94)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C176(1.19)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C176(0.98)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C176(1.00)  LDD1675  [1]
 LDCM0480  CL86 HEK-293T C176(0.99)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C176(1.28)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C176(0.85)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C176(1.16)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C176(1.53)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C176(1.05)  LDD1689  [1]
 LDCM0493  CL98 HEK-293T C176(1.03)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C176(1.15)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C176(1.02)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C176(1.24)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C176(1.13)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587