Details of the Target

General Information of Target

Target ID LDTP10041
Target Name Palmitoyltransferase ZDHHC16 (ZDHHC16)
Gene Name ZDHHC16
Gene ID 84287
Synonyms
APH2; Palmitoyltransferase ZDHHC16; EC 2.3.1.225; Abl-philin 2; Zinc finger DHHC domain-containing protein 16; DHHC-16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGMALARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSIVGMALYTGYVFMPQHI
MAILHYFEIVQ
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization. Also required for eye development. Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function. May play a role in DNA damage response. May be involved in apoptosis regulation. Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway.
Uniprot ID
Q969W1
Ensemble ID
ENST00000345745.9
HGNC ID
HGNC:20714

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.A136T .
LNCaP clone FGC SNV: p.L128M .
LS180 Deletion: p.G56AfsTer17 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C326(7.24)  LDD0170  [1]
DBIA
 Probe Info  		C157(1.05)  LDD1508  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C326(7.24)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C326(7.09)  LDD0171  [1]
 LDCM0215  AC10 HEK-293T C157(1.05)  LDD1508  [2]
 LDCM0259  AC14 HEK-293T C157(1.03)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C157(1.16)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C157(1.04)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C157(0.95)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C157(1.03)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C157(0.98)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C157(0.93)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C157(1.05)  LDD1525  [2]
 LDCM0289  AC29 HEK-293T C157(1.00)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C157(1.07)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C157(0.97)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C157(1.16)  LDD1534  [2]
 LDCM0298  AC37 HEK-293T C157(0.99)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C157(1.08)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C157(1.06)  LDD1539  [2]
 LDCM0304  AC42 HEK-293T C157(1.21)  LDD1543  [2]
 LDCM0307  AC45 HEK-293T C157(1.11)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C157(1.23)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C157(1.11)  LDD1548  [2]
 LDCM0312  AC5 HEK-293T C157(0.88)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C157(1.11)  LDD1552  [2]
 LDCM0316  AC53 HEK-293T C157(1.04)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C157(1.24)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C157(1.11)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C157(1.06)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C157(1.01)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C157(1.02)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C157(1.12)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C157(0.99)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C157(0.87)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C157(1.00)  LDD1511  [2]
 LDCM0367  CL1 HEK-293T C157(1.05)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C157(1.07)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C157(1.04)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C157(0.96)  LDD1575  [2]
 LDCM0374  CL105 HEK-293T C157(1.15)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C157(0.92)  LDD1579  [2]
 LDCM0378  CL109 HEK-293T C157(1.09)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C157(1.03)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C157(1.03)  LDD1584  [2]
 LDCM0383  CL113 HEK-293T C157(0.96)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C157(1.07)  LDD1588  [2]
 LDCM0387  CL117 HEK-293T C157(0.92)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C157(1.11)  LDD1592  [2]
 LDCM0392  CL121 HEK-293T C157(1.05)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C157(1.15)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C157(1.14)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C157(1.00)  LDD1601  [2]
 LDCM0400  CL13 HEK-293T C157(1.02)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C157(1.03)  LDD1605  [2]
 LDCM0405  CL18 HEK-293T C157(1.28)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C157(0.96)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C157(1.34)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C157(1.26)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C157(1.12)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C157(1.13)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C157(0.94)  LDD1618  [2]
 LDCM0419  CL30 HEK-293T C157(1.20)  LDD1623  [2]
 LDCM0422  CL33 HEK-293T C157(1.37)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C157(1.16)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C157(1.16)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C157(1.00)  LDD1630  [2]
 LDCM0432  CL42 HEK-293T C157(1.06)  LDD1636  [2]
 LDCM0435  CL45 HEK-293T C157(1.05)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C157(1.16)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C157(1.09)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C157(0.90)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C157(1.01)  LDD1645  [2]
 LDCM0445  CL54 HEK-293T C157(1.36)  LDD1648  [2]
 LDCM0448  CL57 HEK-293T C157(1.14)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C157(1.29)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C157(1.24)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C157(1.02)  LDD1654  [2]
 LDCM0453  CL61 HEK-293T C157(0.89)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C157(1.04)  LDD1657  [2]
 LDCM0458  CL66 HEK-293T C157(1.22)  LDD1661  [2]
 LDCM0461  CL69 HEK-293T C157(1.18)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C157(1.11)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C157(1.12)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C157(1.09)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C157(0.99)  LDD1670  [2]
 LDCM0471  CL78 HEK-293T C157(1.16)  LDD1674  [2]
 LDCM0475  CL81 HEK-293T C157(1.13)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C157(1.18)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C157(1.11)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C157(0.89)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C157(0.93)  LDD1683  [2]
 LDCM0484  CL9 HEK-293T C157(1.04)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C157(1.49)  LDD1688  [2]
 LDCM0488  CL93 HEK-293T C157(1.08)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C157(1.21)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C157(1.32)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C157(0.90)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C157(0.97)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C157(0.94)  LDD1631  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein YIF1A (YIF1A) YIF1 family O95070
Protein TMED8 (TMED8) . Q6PL24

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402