Details of the Target
General Information of Target
| Target ID | LDTP09978 | |||||
|---|---|---|---|---|---|---|
| Target Name | Betaine--homocysteine S-methyltransferase 1 (BHMT) |
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| Gene Name | BHMT | |||||
| Gene ID | 635 | |||||
| Synonyms |
Betaine--homocysteine S-methyltransferase 1; EC 2.1.1.5 |
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| 3D Structure | ||||||
| Sequence |
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR ST |
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| Target Bioclass |
Enzyme
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| Subcellular location |
Cytoplasm, cytosol
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| Function |
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C131(1.88) | LDD3378 | [1] | |
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IPM Probe Info |
 |
C300(9.60); C299(8.28); C131(1.72) | LDD1701 | [2] | |
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BTD Probe Info |
 |
N.A. | LDD0004 | [3] | |
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WYneO Probe Info |
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N.A. | LDD0022 | [3] | |
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VSF Probe Info |
 |
N.A. | LDD0007 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0548 | 1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one | MDA-MB-231 | C131(0.76); C300(0.81) | LDD2142 | [2] |
| LDCM0510 | 3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C299(1.35); C131(0.99) | LDD2103 | [2] |
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C131(1.15); C300(0.81) | LDD1702 | [2] |
| LDCM0022 | KB02 | 769-P | C131(1.40) | LDD2246 | [1] |
| LDCM0023 | KB03 | MDA-MB-231 | C300(9.60); C299(8.28); C131(1.72) | LDD1701 | [2] |
| LDCM0024 | KB05 | OS-RC-2 | C131(1.88) | LDD3378 | [1] |
| LDCM0509 | N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide | MDA-MB-231 | C131(1.10); C300(1.38) | LDD2102 | [2] |
| LDCM0497 | Nucleophilic fragment 11b | MDA-MB-231 | C131(1.11); C300(1.83) | LDD2090 | [2] |
| LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C131(0.93); C300(1.06) | LDD2092 | [2] |
| LDCM0501 | Nucleophilic fragment 13b | MDA-MB-231 | C300(1.75) | LDD2094 | [2] |
| LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C131(0.75) | LDD2097 | [2] |
| LDCM0505 | Nucleophilic fragment 15b | MDA-MB-231 | C131(0.81); C300(1.95) | LDD2098 | [2] |
| LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C131(0.64) | LDD2100 | [2] |
| LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C131(0.60) | LDD2104 | [2] |
| LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C131(0.54); C300(0.93) | LDD2106 | [2] |
| LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C131(0.77) | LDD2108 | [2] |
| LDCM0517 | Nucleophilic fragment 21b | MDA-MB-231 | C131(0.85); C300(1.98) | LDD2110 | [2] |
| LDCM0521 | Nucleophilic fragment 23b | MDA-MB-231 | C299(1.04); C131(0.66); C300(1.04) | LDD2114 | [2] |
| LDCM0522 | Nucleophilic fragment 24a | MDA-MB-231 | C131(0.68) | LDD2115 | [2] |
| LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C131(0.49) | LDD2134 | [2] |
| LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C131(0.78); C300(0.45) | LDD2141 | [2] |
| LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C300(1.83) | LDD2145 | [2] |
| LDCM0559 | Nucleophilic fragment 9b | MDA-MB-231 | C131(1.29) | LDD2153 | [2] |
The Interaction Atlas With This Target
References