Details of the Target

General Information of Target

Target ID LDTP09957
Target Name Histone acetyltransferase KAT5 (KAT5)
Gene Name KAT5
Gene ID 10524
Synonyms
HTATIP; TIP60; Histone acetyltransferase KAT5; EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; EC 2.3.1.-; Protein acetyltransferase KAT5; EC 2.3.1.-; Protein crotonyltransferase KAT5; EC 2.3.1.-; cPLA(2)-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIEEGHTDQLLEIIQNEKNKVIIKN
MGWNLVGPVVRCLLCKDKEDSKRKVYFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQ
SILLLLQPLQTVIQKLHNKAYSIGLALSTLWNQLSLLPVPYSKEQIQMDDYGLCQCCKAL
IEFTKPFVEEVIDNKENSLENEKLKDELLKFCFKSLKCPLLTAQFFEQSEEGGNDPFRYF
ASEIIGFLSAIGHPFPKMIFNHGRKKRTWNYLEFEEEENKQLADSMASLAYLVFVQGIHI
DQLPMVLSPLYLLQFNMGHIEVFLQRTEESVISKGLELLENSLLRIEDNSLLYQYLEIKS
FLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQGKYTLFRCLLNTSNHSGVEAFI
IQNIKNQIDMSLKRTRNNKWFTGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRY
LVIKDNENDNQTGLWTELGNIENNFLKPLHIGLNMSKAHYEAEIKNSQEAQKSKDLCSIT
VSGEEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENIGIK
Target Bioclass
Enzyme
Family
MYST (SAS/MOZ) family
Subcellular location
Nucleus
Function
Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4. Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription. The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks. Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage. The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes. The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity. Involved in skeletal myoblast differentiation by mediating acetylation of SOX4. Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity. Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts. Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation. Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1. Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase. Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation and 2-hydroxyisobutyrylation, respectively. Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins. Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis. Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes. Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment. Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis.
Uniprot ID
Q92993
Ensemble ID
ENST00000341318.9
HGNC ID
HGNC:5275
ChEMBL ID
CHEMBL5750

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C350(2.78)  LDD3466  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_5
 Probe Info  		C317(0.00); C11(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C499(0.92)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C139(0.97); C499(0.89)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C139(0.94)  LDD1510  [6]
 LDCM0270  AC15 HEK-293T C499(1.02)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C499(0.92)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C139(1.11); C499(0.88)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C499(1.08)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C139(1.18)  LDD1519  [6]
 LDCM0283  AC23 HEK-293T C499(1.11)  LDD1522  [6]
 LDCM0286  AC26 HEK-293T C499(0.95)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C139(1.29); C499(0.82)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C139(1.17)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C139(0.95); C499(0.89)  LDD1529  [6]
 LDCM0292  AC31 HEK-293T C499(1.09)  LDD1531  [6]
 LDCM0295  AC34 HEK-293T C499(1.12)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C139(1.06); C499(0.86)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C139(1.01)  LDD1536  [6]
 LDCM0300  AC39 HEK-293T C499(1.01)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C139(1.22)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C499(0.98)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C139(1.22); C499(0.93)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C139(1.43)  LDD1545  [6]
 LDCM0309  AC47 HEK-293T C499(1.01)  LDD1548  [6]
 LDCM0313  AC50 HEK-293T C499(0.97)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C139(1.22); C499(0.86)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C139(1.04)  LDD1554  [6]
 LDCM0318  AC55 HEK-293T C499(1.02)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C499(1.14)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C139(1.03); C499(0.87)  LDD1561  [6]
 LDCM0324  AC60 HEK-293T C139(1.08)  LDD1563  [6]
 LDCM0327  AC63 HEK-293T C499(0.99)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C499(1.05)  LDD1568  [6]
 LDCM0369  CL100 HEK-293T C499(0.83)  LDD1573  [6]
 LDCM0372  CL103 HEK-293T C499(0.99)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C499(0.85)  LDD1577  [6]
 LDCM0376  CL107 HEK-293T C499(1.02)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C499(0.83)  LDD1581  [6]
 LDCM0379  CL11 HEK-293T C499(1.11)  LDD1583  [6]
 LDCM0381  CL111 HEK-293T C499(1.11)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C499(0.93)  LDD1586  [6]
 LDCM0385  CL115 HEK-293T C499(1.06)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C499(0.93)  LDD1590  [6]
 LDCM0389  CL119 HEK-293T C499(1.02)  LDD1593  [6]
 LDCM0391  CL120 HEK-293T C499(0.95)  LDD1595  [6]
 LDCM0394  CL123 HEK-293T C499(0.95)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C499(0.88)  LDD1599  [6]
 LDCM0398  CL127 HEK-293T C499(0.89)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C499(0.93)  LDD1603  [6]
 LDCM0402  CL15 HEK-293T C499(1.02)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C499(0.90)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C499(0.99)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C139(0.91); C499(0.89)  LDD1610  [6]
 LDCM0408  CL20 HEK-293T C139(1.14)  LDD1612  [6]
 LDCM0411  CL23 HEK-293T C499(1.12)  LDD1615  [6]
 LDCM0415  CL27 HEK-293T C499(1.01)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C499(0.85)  LDD1620  [6]
 LDCM0418  CL3 HEK-293T C499(1.08)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C499(0.93)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C139(1.02); C499(0.85)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C139(0.95)  LDD1625  [6]
 LDCM0424  CL35 HEK-293T C499(1.05)  LDD1628  [6]
 LDCM0428  CL39 HEK-293T C499(1.04)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C499(0.99)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C499(0.85)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C499(1.02)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C139(1.02); C499(0.98)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C139(0.93)  LDD1638  [6]
 LDCM0437  CL47 HEK-293T C499(1.07)  LDD1641  [6]
 LDCM0443  CL52 HEK-293T C499(0.91)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C499(0.97)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C139(0.94); C499(0.93)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C139(1.09)  LDD1650  [6]
 LDCM0450  CL59 HEK-293T C499(1.17)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C499(1.18)  LDD1654  [6]
 LDCM0455  CL63 HEK-293T C499(1.01)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C499(0.95)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C499(0.98)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C139(0.96); C499(0.90)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C139(0.92)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C139(1.12); C499(0.94)  LDD1665  [6]
 LDCM0464  CL71 HEK-293T C499(1.22)  LDD1667  [6]
 LDCM0469  CL76 HEK-293T C499(0.96)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C499(0.92)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C139(0.86); C499(0.92)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C139(0.84)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C139(0.96)  LDD1677  [6]
 LDCM0477  CL83 HEK-293T C499(1.08)  LDD1680  [6]
 LDCM0481  CL87 HEK-293T C499(0.85)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C499(0.89)  LDD1685  [6]
 LDCM0485  CL90 HEK-293T C499(1.17)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C139(1.06); C499(0.81)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C139(0.97)  LDD1690  [6]
 LDCM0490  CL95 HEK-293T C499(1.02)  LDD1693  [6]
 LDCM0494  CL99 HEK-293T C499(1.02)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C499(1.13)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C499(0.94)  LDD1671  [6]
 LDCM0022  KB02 COLO-792 C267(1.53)  LDD2306  [2]
 LDCM0023  KB03 MDA-MB-231 C317(1.89)  LDD1701  [7]
 LDCM0024  KB05 TF-1 C350(2.78)  LDD3466  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 41 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family O43598
Bile acid-CoA:amino acid N-acyltransferase (BAAT) C/M/P thioester hydrolase family Q14032
Pantetheine hydrolase VNN2 (VNN2) BTD/VNN family O95498
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) Complex I NDUFA5 subunit family Q16718
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
DNA polymerase iota (POLI) DNA polymerase type-Y family Q9UNA4
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Lipoyl amidotransferase LIPT1, mitochondrial (LIPT1) LplA family Q9Y234
Thiol S-methyltransferase TMT1A (TMT1A) Methyltransferase superfamily Q9H8H3
Ornithine decarboxylase (ODC1) Orn/Lys/Arg decarboxylase class-II family P11926
Cathepsin O (CTSO) Peptidase C1 family P43234
Ubiquitin carboxyl-terminal hydrolase 38 (USP38) Peptidase C19 family Q8NB14
Secernin-2 (SCRN2) Peptidase C69 family Q96FV2
Carboxypeptidase N catalytic chain (CPN1) Peptidase M14 family P15169
E3 SUMO-protein ligase PIAS3 (PIAS3) PIAS family Q9Y6X2
Purine nucleoside phosphorylase (PNP) PNP/MTAP phosphorylase family P00491
Serine/threonine-protein kinase VRK1 (VRK1) CK1 Ser/Thr protein kinase family Q99986
Mitogen-activated protein kinase 11 (MAPK11) CMGC Ser/Thr protein kinase family Q15759
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Mitogen-activated protein kinase kinase kinase 9 (MAP3K9) STE Ser/Thr protein kinase family P80192
Tyrosine-protein phosphatase non-receptor type 4 (PTPN4) Protein-tyrosine phosphatase family P29074
RuvB-like 1 (RUVBL1) RuvB family Q9Y265
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Rho-related BTB domain-containing protein 1 (RHOBTB1) Rho family O94844
Acyl-coenzyme A thioesterase 13 (ACOT13) Thioesterase PaaI family Q9NPJ3
Thymidine kinase, cytosolic (TK1) Thymidine kinase family P04183
Septin-6 (SEPTIN6) Septin GTPase family Q14141
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tuftelin (TUFT1) Tuftelin family Q9NNX1
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Uracil phosphoribosyltransferase homolog (UPRT) UPRTase family Q96BW1
E3 ubiquitin-protein ligase RNF114 (RNF114) . Q9Y508
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Germ cell-less protein-like 2 (GMCL2) . Q8NEA9
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) . Q86T03
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
PAT complex subunit CCDC47 (CCDC47) CCDC47 family Q96A33
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) Cytochrome b560 family Q99643
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Importin subunit alpha-6 (KPNA5) Importin alpha family O15131
Importin subunit alpha-7 (KPNA6) Importin alpha family O60684
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
MyoD family inhibitor (MDFI) MDFI family Q99750
Cellular tumor antigen p53 (TP53) P53 family P04637
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Sorting nexin-10 (SNX10) Sorting nexin family Q9Y5X0
Sorting nexin-33 (SNX33) Sorting nexin family Q8WV41
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Transmembrane protein 176B (TMEM176B) TMEM176 family Q3YBM2
Sortilin-related receptor (SORL1) VPS10-related sortilin family Q92673
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Stromal interaction molecule 1 (STIM1) . Q13586
Transcription factor
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B13 (HOXB13) Abd-B homeobox family Q92826
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Transcription factor AP-2-beta (TFAP2B) AP-2 family Q92481
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Transcription factor E2F4 (E2F4) E2F/DP family Q16254
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 511 (ZNF511) Krueppel C2H2-type zinc-finger protein family Q8NB15
Zinc finger protein 513 (ZNF513) Krueppel C2H2-type zinc-finger protein family Q8N8E2
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 692 (ZNF692) Krueppel C2H2-type zinc-finger protein family Q9BU19
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
ALX homeobox protein 1 (ALX1) Paired homeobox family Q15699
Krueppel-like factor 12 (KLF12) Sp1 C2H2-type zinc-finger protein family Q9Y4X4
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
DNA-binding protein inhibitor ID-3 (ID3) . Q02535
Golgin-45 (BLZF1) . Q9H2G9
Homeobox protein MOX-2 (MEOX2) . P50222
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Transcription factor 4 (TCF4) . P15884
Transcription factor SOX-10 (SOX10) . P56693
Transcription factor SOX-5 (SOX5) . P35711
Twist-related protein 1 (TWIST1) . Q15672
Zinc finger and BTB domain-containing protein 1 (ZBTB1) . Q9Y2K1
Zinc finger and BTB domain-containing protein 2 (ZBTB2) . Q8N680
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) . Q8NAM6
Zinc finger MYM-type protein 3 (ZMYM3) . Q14202
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
D(1A) dopamine receptor (DRD1) G-protein coupled receptor 1 family P21728
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Other
Click To Hide/Show 78 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ankyrin repeat and SOCS box protein 1 (ASB1) Ankyrin SOCS box (ASB) family Q9Y576
Ataxin-1 (ATXN1) ATXN1 family P54253
B melanoma antigen 1 (BAGE) BAGE family Q13072
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B) CCDC90 family Q9GZT6
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Splicing factor YJU2 (YJU2) CWC16 family Q9BW85
Dexamethasone-induced protein (DEXI) DEXI family O95424
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) EIF-2-beta/eIF-5 family P20042
Eukaryotic translation initiation factor 3 subunit E (EIF3E) EIF-3 subunit E family P60228
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Large ribosomal subunit protein eL33 (RPL35A) Eukaryotic ribosomal protein eL33 family P18077
Protein FAM161A (FAM161A) FAM161 family Q3B820
Fascin-2 (FSCN2) Fascin family O14926
Guanine nucleotide-binding protein subunit alpha-14 (GNA14) G-alpha family O95837
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
Centromere protein V (CENPV) Gfa family Q7Z7K6
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
G kinase-anchoring protein 1 (GKAP1) GKAP1 family Q5VSY0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
HCLS1-associated protein X-1 (HAX1) HAX1 family O00165
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Immunoglobulin-binding protein 1 (IGBP1) IGBP1/TAP42 family P78318
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Colorectal mutant cancer protein (MCC) MCC family P23508
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Dynein axonemal assembly factor 6 (DNAAF6) PIH1 family Q9NQM4
Alpha-2-macroglobulin (A2M) Protease inhibitor I39 (alpha-2-macroglobulin) family P01023
RNA-binding protein EWS (EWSR1) RRM TET family Q01844
RNA-binding protein FUS (FUS) RRM TET family P35637
TATA-binding protein-associated factor 2N (TAF15) RRM TET family Q92804
Lumican (LUM) Small leucine-rich proteoglycan (SLRP) family P51884
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Spermatogenesis-associated protein 2 (SPATA2) SPATA2 family Q9UM82
Serine/arginine-rich splicing factor 2 (SRSF2) Splicing factor SR family Q01130
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
Syntaxin-11 (STX11) Syntaxin family O75558
Transcription initiation factor IIE subunit beta (GTF2E2) TFIIE beta subunit family P29084
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Transmembrane protein 54 (TMEM54) TMEM54 family Q969K7
Translin-associated protein X (TSNAX) Translin family Q99598
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (TRMT6) TRM6/GCD10 family Q9UJA5
Macrophage immunometabolism regulator (MACIR) UNC119-binding protein family Q96GV9
UPF0547 protein C16orf87 (C16orf87) UPF0547 family Q6PH81
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) . Q15027
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Centrosomal protein of 126 kDa (CEP126) . Q9P2H0
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Heat shock factor 2-binding protein (HSF2BP) . O75031
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Insulin-like growth factor-binding protein 3 (IGFBP3) . P17936
Leukemia-associated protein 1 (DLEU1) . O43261
Melanoma-associated antigen H1 (MAGEH1) . Q9H213
Methyl-CpG-binding protein 2 (MECP2) . P51608
Ninein-like protein (NINL) . Q9Y2I6
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) . Q9HC29
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
PRKCA-binding protein (PICK1) . Q9NRD5
Programmed cell death protein 2 (PDCD2) . Q16342
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
RCC1-like G exchanging factor-like protein (RCC1L) . Q96I51
Regulating synaptic membrane exocytosis protein 3 (RIMS3) . Q9UJD0
Rho guanine nucleotide exchange factor 9 (ARHGEF9) . O43307
SERTA domain-containing protein 2 (SERTAD2) . Q14140
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
Vitamin K-dependent protein S (PROS1) . P07225
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24
Zinc finger protein 346 (ZNF346) . Q9UL40

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coenzyme A Small molecular drug DB01992
S-acetyl-cysteine . DB02039

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761