Details of the Target

General Information of Target

Target ID LDTP09631
Target Name Kelch repeat and BTB domain-containing protein 7 (KBTBD7)
Gene Name KBTBD7
Gene ID 84078
Synonyms
Kelch repeat and BTB domain-containing protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDAR
LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE
SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA
DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC
HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ
MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYD
PYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLAD
RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI
VVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPA
RGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT
MLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSS
SFSDDEVWVQVAPQRNAQDQQGSL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Uniprot ID
Q8WVZ9
Ensemble ID
ENST00000379483.4
HGNC ID
HGNC:25266

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C160(2.18)  LDD3332  [1]
IA-alkyne
 Probe Info  		C358(0.00); C160(0.00); C93(0.00)  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C291(0.70)  LDD1093  [3]
 LDCM0230  AC113 PaTu 8988t C291(1.15)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C291(1.14)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C291(1.03)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C291(1.12)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C291(1.29)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C291(1.04)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C291(1.33)  LDD1115  [3]
 LDCM0238  AC120 PaTu 8988t C291(1.04)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C291(1.05)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C291(1.01)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C291(1.07)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C291(1.18)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C291(1.19)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C291(1.18)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C291(1.07)  LDD1124  [3]
 LDCM0279  AC2 PaTu 8988t C291(0.87)  LDD1158  [3]
 LDCM0290  AC3 PaTu 8988t C291(0.81)  LDD1169  [3]
 LDCM0301  AC4 PaTu 8988t C291(0.77)  LDD1180  [3]
 LDCM0312  AC5 PaTu 8988t C291(0.72)  LDD1191  [3]
 LDCM0369  CL100 PaTu 8988t C291(0.63)  LDD1248  [3]
 LDCM0420  CL31 PaTu 8988t C291(0.69)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C291(0.62)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C291(0.56)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C291(0.58)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C291(0.79)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C291(0.24)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C291(0.67)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C291(0.63)  LDD1307  [3]
 LDCM0430  CL40 PaTu 8988t C291(0.65)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C291(0.74)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C291(0.54)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C291(0.56)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C291(0.61)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C291(0.59)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C291(0.89)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C291(0.78)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C291(0.72)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C291(0.76)  LDD1318  [3]
 LDCM0441  CL50 PaTu 8988t C291(0.90)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C291(1.03)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C291(0.98)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C291(0.83)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C291(0.76)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C291(0.74)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C291(0.80)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C291(0.97)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C291(0.72)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C291(0.94)  LDD1329  [3]
 LDCM0452  CL60 PaTu 8988t C291(0.93)  LDD1331  [3]
 LDCM0486  CL91 PaTu 8988t C291(0.87)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C291(0.76)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C291(0.75)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C291(0.72)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C291(0.83)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C291(0.68)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C291(0.67)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C291(0.78)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C291(0.86)  LDD1373  [3]
 LDCM0427  Fragment51 PaTu 8988t C291(0.55)  LDD1306  [3]
 LDCM0022  KB02 22RV1 C160(1.91)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C160(4.39)  LDD2660  [1]
 LDCM0024  KB05 MKN45 C160(2.18)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Coiled-coil domain-containing protein 106 (CCDC106) . Q9BWC9
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.