Details of the Target

General Information of Target

Target ID LDTP09475
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAMTS17)
Gene Name ADAMTS17
Gene ID 170691
Synonyms
A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS 17; ADAM-TS17; ADAMTS-17; EC 3.4.24.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG
SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY
TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND
SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT
RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR
PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY
RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC
RDFYANKMRQPPPNS
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Uniprot ID
Q8TE56
Ensemble ID
ENST00000268070.9
HGNC ID
HGNC:17109

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.R60G .
CAL78 SNV: p.R688G .
CCLP1 SNV: p.P757S .
CCSW1 SNV: p.Q607K .
CORL23 SNV: p.R1062Ter .
DOTC24510 SNV: p.D23H .
DU145 SNV: p.K833N; p.A899D .
HCT15 SNV: p.C967Y; p.T1046A .
KMS27 SNV: p.G600D .
LNCaP clone FGC SNV: p.A240V .
SNU5 SNV: p.E305G .
SW480 SNV: p.S295P .
TOV21G SNV: p.W549C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1058(2.36)  LDD2157  [1]
DBIA
 Probe Info  		C609(1.79)  LDD3427  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C609(1.28)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C609(0.86)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C609(1.00); C955(0.95)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C609(0.94)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C609(1.05)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C609(1.06)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C609(1.55); C955(1.02)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C609(0.94)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C609(1.09)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C609(0.96)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C609(1.04)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C609(1.06)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C609(0.94)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C609(1.03); C955(0.97)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C609(0.90)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C609(1.03); C955(0.98)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C609(0.98)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C609(0.94)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C609(1.19)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C609(0.95)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C609(1.06); C955(1.22)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C609(1.13)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C609(1.10)  LDD1538  [3]
 LDCM0302  AC40 HEK-293T C609(1.05)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C609(1.12)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C609(0.96)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C609(0.81); C955(0.95)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C609(1.08)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C609(1.08)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C609(1.08)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C609(1.21)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C609(0.92)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C609(0.93)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C609(0.97); C955(1.07)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C609(0.94)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C609(1.02)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C609(0.98)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C609(1.20)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C609(0.80)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C609(0.89); C955(0.87)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C609(1.06)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C609(0.94)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C609(1.02)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C609(1.04)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C609(1.07)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C609(0.98)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C609(1.15)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C609(1.05)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C609(1.04); C532(1.03)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C609(1.05)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C609(1.15); C532(0.95)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C609(1.05); C532(0.86)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C609(0.78); C532(1.06)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C609(1.07); C532(0.93)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C609(0.97); C532(0.91)  LDD1591  [3]
 LDCM0390  CL12 HEK-293T C609(1.11)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C609(1.02); C532(0.88)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C609(1.27); C532(0.88)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C609(1.15); C532(0.80)  LDD1604  [3]
 LDCM0404  CL17 HEK-293T C609(1.20)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C609(0.99)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C609(1.08); C955(1.00)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C609(0.95)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C609(1.02)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C609(1.17)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C609(0.87); C532(1.04)  LDD1617  [3]
 LDCM0417  CL29 HEK-293T C609(1.16)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C609(0.76)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C609(1.11); C955(0.90)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C609(1.04)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C609(0.97)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C609(0.94)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C609(1.00); C532(1.13)  LDD1630  [3]
 LDCM0431  CL41 HEK-293T C609(1.10)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C609(0.97)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C609(1.01); C955(1.13)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C609(1.11)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C609(0.98)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C609(1.14)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C609(0.88); C532(0.95)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C609(0.95)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C609(1.31)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C609(1.12)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C609(1.18); C955(1.10)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C609(1.00)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C609(1.24)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C609(0.87)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C609(1.09)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C609(1.23); C532(0.99)  LDD1656  [3]
 LDCM0457  CL65 HEK-293T C609(1.23)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C609(1.10)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C609(0.99); C955(0.93)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C609(0.93)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C609(1.27); C955(0.97)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C609(1.07)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C609(1.11)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C609(0.98); C532(0.86)  LDD1669  [3]
 LDCM0470  CL77 HEK-293T C609(1.08)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C609(0.94)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C609(1.06); C955(1.13)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C609(1.20)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C609(0.98)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C609(1.10)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C609(1.05); C532(0.83)  LDD1682  [3]
 LDCM0483  CL89 HEK-293T C609(1.18)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C609(0.90)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C609(1.13)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C609(0.96); C955(0.88)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C609(1.04)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C609(1.10)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C609(1.06)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C609(0.97); C532(0.86)  LDD1695  [3]
 LDCM0022  KB02 COLO-679 C609(1.24)  LDD2305  [2]
 LDCM0023  KB03 COLO-679 C609(1.29)  LDD2722  [2]
 LDCM0024  KB05 SK-MEL-28 C609(1.79)  LDD3427  [2]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402