Details of the Target

General Information of Target

Target ID LDTP09433
Target Name Actin-related protein T1 (ACTRT1)
Gene Name ACTRT1
Gene ID 139741
Synonyms
ARPT1; Actin-related protein T1; ARP-T1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFNPHALDVPAVIFDNGSGLCKAGLSGEIGPRHVISSVLGHCKFNVPLARLNQKYFVGQE
ALYKYEALHLHYPIERGLVTGWDDMEKLWKHLFERELGVKPSQQPVLMTEPSLNPREIRE
KLAEMMFETFSVPGFYLSNHAVAALYASACVTGLVVDSGDGVTCTVPIFEGYSLPHAVTK
LCMAGRDITEHLTRLLFASGFNFPCILNKAVVNNIKEKLCYIALEPEKELRKSRGEVLGA
YRLPDGHVIHFGDELYQVPEVLFAPDQLGIHSPGLSKMVSSSIMKCDTDIQNKLYADIVL
SGGTTLLPGLEERLMKEVEQLASKGTPIKITASPDRCFSAWIGASIMTSMSSFKQMWVTS
ADFKEYGTSVVQRRCF
Target Bioclass
Other
Family
Actin family
Subcellular location
Cytoplasm, cytoskeleton
Function Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
Uniprot ID
Q8TDG2
Ensemble ID
ENST00000371124.5
HGNC ID
HGNC:24027

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C182(1.26)  LDD0304  [1]
DBIA
 Probe Info  		C182(5.45)  LDD3332  [2]
BTD
 Probe Info  		C182(0.85)  LDD2089  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C182(0.47)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C182(1.15)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C182(1.01)  LDD2152  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C182(0.46)  LDD2131  [3]
 LDCM0498  BS-3668 MDA-MB-231 C182(0.49)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C182(3.68)  LDD1702  [3]
 LDCM0022  KB02 769-P C182(3.20)  LDD2246  [2]
 LDCM0023  KB03 MDA-MB-231 C182(15.66)  LDD1701  [3]
 LDCM0024  KB05 MKN45 C182(5.45)  LDD3332  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C182(0.67)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0231  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C182(0.85)  LDD2089  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C182(1.13)  LDD2098  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C182(1.10)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C182(0.74)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C182(1.04)  LDD2110  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C182(0.52)  LDD2114  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C182(0.67)  LDD2120  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C182(1.00)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C182(1.07)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C182(0.72)  LDD2128  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C182(1.33)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C182(1.20)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C182(0.91)  LDD2137  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C182(0.64)  LDD2143  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C182(7.21)  LDD2145  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C182(1.09)  LDD2147  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C182(0.58)  LDD2150  [3]
 LDCM0131  RA190 MM1.R C182(1.26)  LDD0304  [1]

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.