Details of the Target
General Information of Target
| Target ID | LDTP09211 | |||||
|---|---|---|---|---|---|---|
| Target Name | Interleukin-17 receptor D (IL17RD) | |||||
| Gene Name | IL17RD | |||||
| Gene ID | 54756 | |||||
| Synonyms |
IL17RLM; SEF; Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; IL17Rhom; Interleukin-17 receptor-like protein; Sef homolog; hSef |
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| 3D Structure | ||||||
| Sequence |
MAPWLQLCSVFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLYNITFKY
DNCTTYLNPVGKHVIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKS EGRQCQQLILKDPKQLNSSFKRTGMESQPFLNMKFETDYFVKVVPFPSIKNESNYHPFFF RTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMQVSFDHAPHNFGFRFFYLHYKLKHEG PFKRKTCKQEQTTETTSCLLQNVSPGDYIIELVDDTNTTRKVMHYALKPVHSPWAGPIRA VAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESSESSTYTAALPRERLRPRPKVFL CYSSKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIV VCSKGMKYFVDKKNYKHKGGGRGSGKGELFLVAVSAIAEKLRQAKQSSSAALSKFIAVYF DYSCEGDVPGILDLSTKYRLMDNLPQLCSHLHSRDHGLQEPGQHTRQGSRRNYFRSKSGR SLYVAICNMHQFIDEEPDWFEKQFVPFHPPPLRYREPVLEKFDSGLVLNDVMCKPGPESD FCLKVEAAVLGATGPADSQHESQHGGLDQDGEARPALDGSAALQPLLHTVKAGSPSDMPR DSGIYDSSVPSSELSLPLMEGLSTDQTETSSLTESVSSSSGLGEEEPPALPSKLLSSGSC KADLGCRSYTDELHAVAPL |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm; Golgi apparatus membrane
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| Function |
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
FBPP2 Probe Info |
 |
2.85 | LDD0318 | [1] | |
|
DBIA Probe Info |
 |
C720(1.23) | LDD3393 | [2] | |
|
BTD Probe Info |
 |
C602(0.72) | LDD2100 | [3] | |
|
Phosphinate-6 Probe Info |
 |
N.A. | LDD0018 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C602(1.43) | LDD2112 | [3] |
| LDCM0022 | KB02 | ABC-1 | C720(1.69) | LDD2262 | [2] |
| LDCM0023 | KB03 | ABC-1 | C720(1.40) | LDD2679 | [2] |
| LDCM0024 | KB05 | PaTu 8988t | C720(1.23) | LDD3393 | [2] |
| LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C602(0.72) | LDD2100 | [3] |
| LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C602(0.45) | LDD2106 | [3] |
| LDCM0517 | Nucleophilic fragment 21b | MDA-MB-231 | C602(0.49) | LDD2110 | [3] |
| LDCM0540 | Nucleophilic fragment 35 | MDA-MB-231 | C602(1.10) | LDD2133 | [3] |
| LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C602(0.74) | LDD2141 | [3] |
| LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C602(1.04) | LDD2145 | [3] |
References