Details of the Target

General Information of Target

Target ID LDTP09208
Target Name Bardet-Biedl syndrome 1 protein (BBS1)
Gene Name BBS1
Gene ID 582
Synonyms
BBS2L2; Bardet-Biedl syndrome 1 protein; BBS2-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAASSSDSDACGAESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLG
PGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRP
YFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELS
EMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILA
KMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHK
VLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRD
KALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPA
QAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLST
TAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLL
VPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA
Target Bioclass
Transporter and channel
Subcellular location
Cell projection, cilium membrane
Function
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Plays a role in olfactory cilium biogenesis/maintenance and trafficking.
Uniprot ID
Q8NFJ9
Ensemble ID
ENST00000318312.12
HGNC ID
HGNC:966

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.S6L .
MCC13 SNV: p.P66L .
MFE319 SNV: p.A351V .
MOLT4 Deletion: p.L239Ter .
OVCAR5 SNV: p.R277G .
TE4 SNV: p.C218Ter .
TE8 SNV: p.K403R .
UMUC3 SNV: p.H312R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C148(2.01)  LDD3423  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C377(0.97)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C377(0.91)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C377(0.63)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C111(1.05); C377(0.83)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C377(1.17)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C377(0.89)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C377(0.74)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C377(0.82)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C111(1.00); C377(0.93)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C377(1.11)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C377(0.85)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C377(0.94)  LDD1527  [3]
 LDCM0292  AC31 HEK-293T C111(1.13); C377(0.97)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C377(1.18)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C377(1.06)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C377(0.76)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C111(1.12); C377(0.81)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C377(0.77)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C377(0.97)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C377(0.87)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C377(0.78)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C111(1.22); C377(0.79)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C377(1.00)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C377(0.96)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C377(0.92)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C111(0.86); C377(1.07)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C377(1.16)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C377(1.24)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C377(0.82)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C111(1.19); C377(0.76)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C111(1.18); C377(0.88)  LDD1568  [3]
 LDCM0356  AKOS034007680 HEK-293T C377(1.06)  LDD1570  [3]
 LDCM0367  CL1 HEK-293T C111(1.01); C377(1.34)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C377(1.16)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C111(1.07); C377(1.16)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C377(1.01)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C377(1.06)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C111(0.96); C377(0.80)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C377(0.78)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C377(0.93)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C111(0.99); C377(0.63)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C111(0.94); C377(1.05)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C377(0.75)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C377(1.03)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C111(1.07); C377(0.94)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C377(0.82)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C377(1.05)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C111(0.93); C377(0.81)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C377(0.98)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C377(1.14)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C111(0.90); C377(0.80)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C377(0.83)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C377(0.93)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C111(0.78); C377(1.15)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C377(0.85)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C377(0.92)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C111(0.95); C377(1.20)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C377(0.93)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C377(1.10)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C377(1.26)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C377(1.11)  LDD1609  [3]
 LDCM0408  CL20 HEK-293T C377(1.05)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C111(0.97); C377(1.20)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C111(0.99); C377(0.90)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C377(0.87)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C377(0.72)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C377(1.02)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C377(0.95)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C377(0.86)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C377(1.03)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C111(1.01); C377(0.84)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C111(0.91); C377(0.93)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C377(0.77)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C377(0.95)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C377(1.08)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C377(1.13)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C377(0.88)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C377(0.72)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C111(1.18); C377(1.01)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C111(0.96); C377(0.92)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C377(1.09)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C377(0.76)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C377(1.13)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C377(0.96)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C377(0.77)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C111(0.98); C377(1.05)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C377(0.85)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C111(0.81); C377(0.93)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C377(0.90)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C377(0.86)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C377(0.86)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C377(0.73)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C377(0.79)  LDD1663  [3]
 LDCM0464  CL71 HEK-293T C111(0.87); C377(0.99)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C111(1.11); C377(0.82)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C377(0.77)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C377(1.25)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C377(0.84)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C377(1.03)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C377(1.11)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C111(1.09); C377(0.84)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C111(0.79); C377(0.89)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C377(0.99)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C377(0.91)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C377(1.13)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C377(0.83)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C377(0.87)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C111(1.27); C377(0.92)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C111(0.92); C377(0.78)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C377(0.98)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C377(0.98)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C377(0.84)  LDD1671  [3]
 LDCM0022  KB02 HEK-293T C111(0.95); C377(1.26)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C111(0.99); C377(0.94)  LDD1497  [3]
 LDCM0024  KB05 SK-ES1 C148(2.01)  LDD3423  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fructose-bisphosphate aldolase B (ALDOB) Class I fructose-bisphosphate aldolase family P05062
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
ADP-ribosylation factor-like protein 6 (ARL6) Arf family Q9H0F7
Elongation factor 1-alpha 1 (EEF1A1) Classic translation factor GTPase family P68104
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bardet-Biedl syndrome 4 protein (BBS4) BBS4 family Q96RK4
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
Bardet-Biedl syndrome 2 protein (BBS2) . Q9BXC9
Bardet-Biedl syndrome 7 protein (BBS7) . Q8IWZ6
Protein PTHB1 (BBS9) . Q3SYG4
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
IQ calmodulin-binding motif-containing protein 1 (IQCB1) . Q15051

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402