Details of the Target

General Information of Target

Target ID LDTP09154
Target Name Phospholipid phosphatase 5 (PLPP5)
Gene Name PLPP5
Gene ID 84513
Synonyms
DPPL1; HTPAP; PPAPDC1B; Phospholipid phosphatase 5; EC 3.1.3.4; EC 3.6.1.75; Phosphatidic acid phosphatase type 2 domain-containing protein 1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPM
FVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFY
RCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRG
KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAEC
HKPFQDKLVLSTAQKPGDSYCFDI
Target Bioclass
Enzyme
Family
PA-phosphatase related phosphoesterase family
Subcellular location
Cell membrane
Function
Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.
Uniprot ID
Q8NEB5
Ensemble ID
ENST00000419686.2
HGNC ID
HGNC:25026

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.E40Ter .
HDMYZ SNV: p.F24I .
IM95 SNV: p.P149T .
LNCaP clone FGC SNV: p.P124H .
NCIH1155 SNV: p.G169W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C261(0.95)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C261(0.95)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C261(1.22); C173(1.05)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C261(1.30)  LDD1517  [1]
 LDCM0283  AC23 HEK-293T C261(0.81); C173(1.00)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C261(0.99)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C261(1.21)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C261(1.17)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C261(0.91); C173(1.00)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C261(1.10)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C261(1.17)  LDD1535  [1]
 LDCM0300  AC39 HEK-293T C261(1.07); C173(1.03)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C261(1.05)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C261(1.03)  LDD1544  [1]
 LDCM0309  AC47 HEK-293T C261(1.03); C173(1.00)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C261(1.09)  LDD1549  [1]
 LDCM0314  AC51 HEK-293T C261(1.17)  LDD1553  [1]
 LDCM0318  AC55 HEK-293T C261(1.03); C173(1.03)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C261(1.09)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C261(1.17)  LDD1561  [1]
 LDCM0327  AC63 HEK-293T C261(1.18); C173(1.04)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C261(1.09)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C261(1.09); C173(0.95)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C261(1.25)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C261(1.04)  LDD1514  [1]
 LDCM0371  CL102 HEK-293T C261(1.08)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C261(1.04)  LDD1579  [1]
 LDCM0379  CL11 HEK-293T C261(0.94); C173(1.10)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C261(1.02)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C261(0.86)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C261(1.11)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C261(0.94)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C261(1.19)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C261(1.01)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C261(0.96)  LDD1605  [1]
 LDCM0406  CL19 HEK-293T C261(0.89)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C261(1.10)  LDD1611  [1]
 LDCM0411  CL23 HEK-293T C261(0.83); C173(1.12)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C261(0.86)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C261(0.82)  LDD1618  [1]
 LDCM0420  CL31 HEK-293T C261(1.08)  LDD1624  [1]
 LDCM0424  CL35 HEK-293T C261(0.78); C173(1.05)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C261(0.72)  LDD1629  [1]
 LDCM0433  CL43 HEK-293T C261(0.88)  LDD1637  [1]
 LDCM0437  CL47 HEK-293T C261(0.85); C173(1.02)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C261(0.89)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C261(1.45)  LDD1645  [1]
 LDCM0446  CL55 HEK-293T C261(0.83)  LDD1649  [1]
 LDCM0450  CL59 HEK-293T C261(0.77); C173(1.14)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C261(0.83)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C261(1.43)  LDD1657  [1]
 LDCM0459  CL67 HEK-293T C261(0.91)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C261(0.87)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C261(0.65); C173(1.07)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C261(0.93)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C261(0.82)  LDD1670  [1]
 LDCM0472  CL79 HEK-293T C261(0.89)  LDD1675  [1]
 LDCM0477  CL83 HEK-293T C261(0.88); C173(1.00)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C261(0.86)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C261(0.88)  LDD1683  [1]
 LDCM0486  CL91 HEK-293T C261(0.92)  LDD1689  [1]
 LDCM0490  CL95 HEK-293T C261(0.87); C173(1.27)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C261(1.00)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C261(0.95)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C261(1.01)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402