Details of the Target
General Information of Target
| Target ID | LDTP09089 | |||||
|---|---|---|---|---|---|---|
| Target Name | Sugar phosphate exchanger 3 (SLC37A3) | |||||
| Gene Name | SLC37A3 | |||||
| Gene ID | 84255 | |||||
| Synonyms |
SPX3; Sugar phosphate exchanger 3; Solute carrier family 37 member 3 |
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| 3D Structure | ||||||
| Sequence |
MAWPNVFQRGSLLSQFSHHHVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTS
VELPVEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMC SSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFG LWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLSGIE AEENFEEDSHRPLINGGENEDEYEPNYSIQDDSSVAQVKAISFYQACCLPGVIPYSLAYA CLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRAPVL ALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSS EALATVTGIVDGSGSIGAAVGQYLVSLIRDKLGWMWVFYFFILMTSCTIVFISPLIVREI FSLVLRRQAHILRE |
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| Target Bioclass |
Transporter and channel
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| Family |
Major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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C169 Probe Info |
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27.47 | LDD1849 | [1] | |
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C170 Probe Info |
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11.08 | LDD1850 | [1] | |