Details of the Target

General Information of Target

Target ID LDTP08977
Target Name Zinc finger protein 513 (ZNF513)
Gene Name ZNF513
Gene ID 130557
Synonyms
Zinc finger protein 513
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEEEEEEEGDGNSD
QLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEARGERPGPAC
QLCGGPTGEGPCCGAGGPGGGPLLPPRLLYSCRLCTFVSHYSSHLKRHMQTHSGEKPFRC
GRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFACSSLGNLRRHQRTHAGPPTPPCPTCG
FRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGLC
GTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGGASGGPQGPSDKGF
ACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAHLDNLKRHQRVHTGEKPYKCPL
CPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYT
TGHWDNYKRHQKVHGHGGAGGPGLSASEGWAPPHSPPSVLSSRGPPALGTAGSRAVHTDS
S
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional regulator that plays a role in retinal development and maintenance.
Uniprot ID
Q8N8E2
Ensemble ID
ENST00000323703.11
HGNC ID
HGNC:26498

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C236(0.76); C239(0.76)  LDD0533  [1]
IPIAA_L
 Probe Info  		C243(0.00); C244(0.00)  LDD0031  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C236(0.76); C239(0.76)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C236(0.93); C239(0.93)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C236(0.72); C239(0.72)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C236(0.97); C239(0.97)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C236(0.92); C239(0.92)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C236(1.32); C239(1.32)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C236(0.92); C239(0.92)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C236(0.97); C239(0.96)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C236(0.67); C239(0.68)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C236(0.81); C239(0.72)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C236(0.70); C239(0.80)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C236(0.72); C239(0.83)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C236(0.94); C239(0.92)  LDD0546  [1]
 LDCM0263  AC143 HCT 116 C236(0.83); C239(0.83)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C236(1.04); C239(1.04)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C236(0.98); C239(0.98)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C236(0.90); C239(0.90)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C236(0.96); C239(0.96)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C236(1.10); C239(1.10)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C236(1.16); C239(1.16)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C236(0.71); C239(0.71)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C236(1.13); C239(1.13)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C236(0.91); C239(0.91)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C236(1.27); C239(1.27)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C236(1.14); C239(1.14)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C236(1.06); C239(1.06)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C236(0.86); C239(0.86)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C236(1.62); C239(1.62)  LDD2161  [1]
 LDCM0320  AC57 HCT 116 C236(1.41); C239(1.41)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C236(1.60); C239(1.60)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C236(2.03); C239(2.03)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C236(1.50); C239(1.50)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C236(1.53); C239(1.53)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C236(1.69); C239(1.69)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C236(1.44); C239(1.44)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C236(1.56); C239(1.56)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C236(1.19); C239(1.19)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C236(1.07); C239(1.07)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C236(1.13); C239(1.13)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C236(0.95); C239(0.95)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C236(1.00); C239(1.00)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C236(2.00); C239(2.00)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C236(0.87); C239(0.87)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C236(0.91); C239(0.91)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C236(1.67); C239(1.67)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C236(1.24); C239(1.24)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C236(1.76); C239(1.76)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C236(1.17); C239(1.17)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C236(1.14); C239(1.14)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C236(1.24); C239(1.24)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C236(0.87); C239(0.87)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C236(1.34); C239(1.34)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C236(0.68); C239(0.68)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C236(1.40); C239(1.40)  LDD0665  [1]
 LDCM0365  AC98 HCT 116 C236(1.15); C239(1.15)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C236(0.70); C239(0.70)  LDD0683  [1]
 LDCM0396  CL125 HCT 116 C236(1.14); C239(1.14)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C236(1.00); C239(1.00)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C236(1.24); C239(1.24)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C236(1.53); C239(1.53)  LDD0716  [1]
 LDCM0022  KB02 A2780 C336(1.35)  LDD2254  [3]
 LDCM0023  KB03 A2780 C336(1.41)  LDD2671  [3]
 LDCM0024  KB05 NB1 C336(1.41)  LDD3340  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840