Details of the Target

General Information of Target

Target ID LDTP08834
Target Name Homologous recombination OB-fold protein (HROB)
Gene Name HROB
Gene ID 78995
Synonyms
C17orf53; Homologous recombination OB-fold protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACSLQKLFAVEEEFEDEDFLSAVEDAENRFTGSLPVNAGRLRPVSSRPQETVQAQSSRL
LLLHPTAPSEALGLPDLDLCLPASSTPSADSRPSCIGAAPLRPVSTSSSWIGNQRRVTVT
EVLRETARPQSSALHPLLTFESQQQQVGGFEGPEQDEFDKVLASMELEEPGMELECGVSS
EAIPILPAQQREGSVLAKKARVVDLSGSCQKGPVPAIHKAGIMSAQDESLDPVIQCRTPR
PPLRPGAVGHLPVPTALTVPTQQLHWEVCPQRSPVQALQPLQAARGTIQSSPQNRFPCQP
FQSPSSWLSGKAHLPRPRTPNSSCSTPSRTSSGLFPRIPLQPQAPVSSIGSPVGTPKGPQ
GALQTPIVTNHLVQLVTAASRTPQQPTHPSTRAKTRRFPGPAGILPHQQSGRSLEDIMVS
APQTPTHGALAKFQTEIVASSQASVEEDFGRGPWLTMKSTLGLDERDPSCFLCTYSIVMV
LRKQAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMQGTVHRLLLETCQNELK
PGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSPDSGDGSFLKPSQPFPKDSGSFQHDV
AAKPEEGFRTAQNLEAEASPEEELPEADDLDGLLSELPEDFFCGTSS
Target Bioclass
Other
Subcellular location
Nucleus
Function DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
Uniprot ID
Q8N3J3
Ensemble ID
ENST00000245382.6
HGNC ID
HGNC:28460

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C324(3.07)  LDD3397  [1]
IA-alkyne
 Probe Info  		C209(5.53)  LDD1706  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C324(1.12)  LDD0812  [5]
 LDCM0226  AC11 HEK-293T C535(1.05)  LDD1509  [6]
 LDCM0270  AC15 HEK-293T C535(1.19)  LDD1513  [6]
 LDCM0278  AC19 HEK-293T C535(0.97)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C324(1.33)  LDD0877  [5]
 LDCM0283  AC23 HEK-293T C535(1.10)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C209(1.07); C176(1.47)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C324(1.13)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C324(1.34)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C324(0.94)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C324(0.88)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C324(1.70)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C324(1.12)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C324(1.11)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C324(1.19)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C324(0.95)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C324(1.29)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C324(1.07)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C535(1.03)  LDD1535  [6]
 LDCM0300  AC39 HEK-293T C535(1.23)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C324(1.13)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C209(1.12); C176(1.34)  LDD1541  [6]
 LDCM0305  AC43 HEK-293T C535(1.10)  LDD1544  [6]
 LDCM0308  AC46 HEK-293T C324(1.25)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C324(1.09)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C324(1.25)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C324(1.44)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C324(1.50)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C324(1.43)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C324(1.49)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C324(1.74)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C324(1.19)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C324(1.46)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C324(1.32)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C324(1.37)  LDD0917  [5]
 LDCM0322  AC59 HEK-293T C535(1.18)  LDD1561  [6]
 LDCM0327  AC63 HEK-293T C535(1.14)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C209(1.00); C176(1.72)  LDD1567  [6]
 LDCM0332  AC68 HEK-293T C324(0.89)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C324(0.96)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C535(1.09)  LDD1568  [6]
 LDCM0335  AC70 HEK-293T C324(1.20)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C324(1.69)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C324(1.06)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C324(1.15)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C324(1.08)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C324(1.29)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C324(0.92)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C324(0.89)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C324(0.96)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C324(0.92)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C209(1.05); C176(0.94)  LDD1569  [6]
 LDCM0346  AC80 HEK-293T C324(0.95)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C324(1.04)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C324(1.47)  LDD0946  [5]
 LDCM0275  AKOS034007705 HEK-293T C209(1.06); C176(1.05)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C535(1.16)  LDD1571  [6]
 LDCM0369  CL100 HEK-293T C324(1.41)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C535(1.09)  LDD1574  [6]
 LDCM0372  CL103 HEK-293T C535(1.11)  LDD1576  [6]
 LDCM0374  CL105 HEK-293T C535(1.15)  LDD1578  [6]
 LDCM0376  CL107 HEK-293T C535(0.95)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C535(1.18)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C535(0.99)  LDD1583  [6]
 LDCM0381  CL111 HEK-293T C535(0.85)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C324(1.14)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C324(1.21)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C324(2.07)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C324(0.98)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C324(1.28)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C535(1.41)  LDD1591  [6]
 LDCM0389  CL119 HEK-293T C535(1.01)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C209(1.03); C176(1.62)  LDD1594  [6]
 LDCM0392  CL121 HEK-293T C324(1.42)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C324(1.24)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C324(1.28)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C324(1.33)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C535(1.27)  LDD1600  [6]
 LDCM0398  CL127 HEK-293T C535(1.17)  LDD1602  [6]
 LDCM0400  CL13 HEK-293T C535(1.06)  LDD1604  [6]
 LDCM0402  CL15 HEK-293T C535(1.00)  LDD1606  [6]
 LDCM0406  CL19 HEK-293T C535(0.96)  LDD1610  [6]
 LDCM0411  CL23 HEK-293T C535(1.07)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C209(1.22); C176(1.02)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C535(1.20)  LDD1617  [6]
 LDCM0415  CL27 HEK-293T C535(0.92)  LDD1619  [6]
 LDCM0418  CL3 HEK-293T C535(1.20)  LDD1622  [6]
 LDCM0420  CL31 HEK-293T C535(1.01)  LDD1624  [6]
 LDCM0424  CL35 HEK-293T C535(1.01)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C209(1.07); C176(0.86)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C535(1.17)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C535(1.04)  LDD1632  [6]
 LDCM0433  CL43 HEK-293T C535(0.96)  LDD1637  [6]
 LDCM0437  CL47 HEK-293T C535(0.94)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C209(1.00); C176(1.59)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C535(1.12)  LDD1643  [6]
 LDCM0446  CL55 HEK-293T C535(1.00)  LDD1649  [6]
 LDCM0450  CL59 HEK-293T C535(1.04)  LDD1653  [6]
 LDCM0452  CL60 HEK-293T C209(1.10); C176(0.99)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C535(1.28)  LDD1656  [6]
 LDCM0455  CL63 HEK-293T C535(1.16)  LDD1658  [6]
 LDCM0459  CL67 HEK-293T C535(1.02)  LDD1662  [6]
 LDCM0462  CL7 HEK-293T C535(1.03)  LDD1665  [6]
 LDCM0464  CL71 HEK-293T C535(1.02)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C209(1.18); C176(1.43)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C535(1.04)  LDD1669  [6]
 LDCM0472  CL79 HEK-293T C535(0.96)  LDD1675  [6]
 LDCM0477  CL83 HEK-293T C535(0.93)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C209(1.07); C176(1.14)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C535(1.45)  LDD1682  [6]
 LDCM0481  CL87 HEK-293T C535(0.93)  LDD1684  [6]
 LDCM0486  CL91 HEK-293T C324(1.22)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C324(1.41)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C324(1.47)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C324(1.84)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C324(2.55)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C324(1.45)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C324(1.43)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C324(1.65)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C324(1.23)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C535(0.69)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C535(1.01)  LDD1671  [6]
 LDCM0022  KB02 HEK-293T C209(0.97)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C209(0.96)  LDD1497  [6]
 LDCM0024  KB05 PF-382 C324(3.07)  LDD3397  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402